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• W4224288052 endingPage "290" @default.
• W4224288052 startingPage "275" @default.
• W4224288052 abstract "Drug addiction is a chronic brain disease characterized by compulsive drug-seeking and drug-taking behaviors despite the major negative consequences. Current well-established neuronal underpinnings of drug addiction have promoted the substantial progress in understanding this disorder. However, non-neuronal mechanisms of drug addiction have long been underestimated. Fortunately, increased evidence indicates that neuroimmune system, especially Toll-like receptor 4 (TLR4) signaling, plays an important role in the different stages of drug addiction. Drugs like opioids, psychostimulants, and alcohol activate TLR4 signaling and enhance the proinflammatory response, which is associated with drug reward-related behaviors. While extensive studies have shown that inhibition of TLR4 attenuated drug-related responses, there are conflicting findings implicating that TLR4 signaling may not be essential to drug addiction. In this chapter, preclinical and clinical studies will be discussed to further evaluate whether TLR4-based neuroimmune pharmacotherapy can be used to treat drug addiction. Furthermore, the possible mechanisms underlying the effects of TLR4 inhibition in modulating drug-related behaviors will also be discussed." @default.
• W4224288052 created "2022-04-26" @default.
• W4224288052 creator A5007550740 @default.
• W4224288052 creator A5012267050 @default.
• W4224288052 creator A5052062095 @default.
• W4224288052 date "2022-01-01" @default.
• W4224288052 modified "2023-09-27" @default.
• W4224288052 title "Toll-Like Receptor 4: A Novel Target to Tackle Drug Addiction?" @default.
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