Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224291212> ?p ?o ?g. }
- W4224291212 abstract "Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12F36V (dTAGs) or HaloTag7 (HaloPROTACs) are powerful approaches for preclinical target validation. Interchanging tags and tag-targeting degraders is important to achieve efficient substrate degradation, yet limited degrader/tag pairs are available and side-by-side comparisons have not been performed. To expand the tTPD repertoire we developed catalytic NanoLuc-targeting PROTACs (NanoTACs) to hijack the CRL4CRBN complex and degrade NanoLuc tagged substrates, enabling rapid luminescence-based degradation screening. To benchmark NanoTACs against existing tTPD systems we use an interchangeable reporter system to comparatively test optimal degrader/tag pairs. Overall, we find the dTAG system exhibits superior degradation. To align tag-induced degradation with physiology we demonstrate that NanoTACs limit MLKL-driven necroptosis. In this work we extend the tTPD platform to include NanoTACs adding flexibility to tTPD studies, and benchmark each tTPD system to highlight the importance of comparing each system against each substrate." @default.
- W4224291212 created "2022-04-26" @default.
- W4224291212 creator A5001751944 @default.
- W4224291212 creator A5002484029 @default.
- W4224291212 creator A5006189775 @default.
- W4224291212 creator A5009011624 @default.
- W4224291212 creator A5012092459 @default.
- W4224291212 creator A5018783420 @default.
- W4224291212 creator A5028853121 @default.
- W4224291212 creator A5030814799 @default.
- W4224291212 creator A5031767261 @default.
- W4224291212 creator A5036373931 @default.
- W4224291212 creator A5041246235 @default.
- W4224291212 creator A5045374257 @default.
- W4224291212 creator A5046427306 @default.
- W4224291212 creator A5046678035 @default.
- W4224291212 creator A5049927866 @default.
- W4224291212 creator A5052332289 @default.
- W4224291212 creator A5059828424 @default.
- W4224291212 creator A5060864525 @default.
- W4224291212 creator A5061968220 @default.
- W4224291212 creator A5080942529 @default.
- W4224291212 creator A5081510532 @default.
- W4224291212 creator A5087888938 @default.
- W4224291212 creator A5090059849 @default.
- W4224291212 date "2022-04-19" @default.
- W4224291212 modified "2023-10-05" @default.
- W4224291212 title "Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms" @default.
- W4224291212 cites W1565539350 @default.
- W4224291212 cites W1965813899 @default.
- W4224291212 cites W1993613360 @default.
- W4224291212 cites W2002111767 @default.
- W4224291212 cites W2020271342 @default.
- W4224291212 cites W2069800916 @default.
- W4224291212 cites W2134178604 @default.
- W4224291212 cites W2135450099 @default.
- W4224291212 cites W2171537806 @default.
- W4224291212 cites W2206983740 @default.
- W4224291212 cites W2265728551 @default.
- W4224291212 cites W2292464399 @default.
- W4224291212 cites W2325427926 @default.
- W4224291212 cites W2400416067 @default.
- W4224291212 cites W2548552592 @default.
- W4224291212 cites W2557181747 @default.
- W4224291212 cites W2588665584 @default.
- W4224291212 cites W2592787461 @default.
- W4224291212 cites W2597078857 @default.
- W4224291212 cites W2610481986 @default.
- W4224291212 cites W2792453707 @default.
- W4224291212 cites W2808059176 @default.
- W4224291212 cites W2883024539 @default.
- W4224291212 cites W2900523669 @default.
- W4224291212 cites W2912114516 @default.
- W4224291212 cites W2914693193 @default.
- W4224291212 cites W2917078121 @default.
- W4224291212 cites W2938455624 @default.
- W4224291212 cites W2941268034 @default.
- W4224291212 cites W2988241748 @default.
- W4224291212 cites W2996636067 @default.
- W4224291212 cites W3000673710 @default.
- W4224291212 cites W3000715281 @default.
- W4224291212 cites W3025173962 @default.
- W4224291212 cites W3033572181 @default.
- W4224291212 cites W3040830058 @default.
- W4224291212 cites W3041242267 @default.
- W4224291212 cites W3081170494 @default.
- W4224291212 cites W3087526660 @default.
- W4224291212 cites W3111135047 @default.
- W4224291212 cites W3207463170 @default.
- W4224291212 cites W3208691473 @default.
- W4224291212 doi "https://doi.org/10.1038/s41467-022-29670-1" @default.
- W4224291212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35440107" @default.
- W4224291212 hasPublicationYear "2022" @default.
- W4224291212 type Work @default.
- W4224291212 citedByCount "8" @default.
- W4224291212 countsByYear W42242912122022 @default.
- W4224291212 countsByYear W42242912122023 @default.
- W4224291212 crossrefType "journal-article" @default.
- W4224291212 hasAuthorship W4224291212A5001751944 @default.
- W4224291212 hasAuthorship W4224291212A5002484029 @default.
- W4224291212 hasAuthorship W4224291212A5006189775 @default.
- W4224291212 hasAuthorship W4224291212A5009011624 @default.
- W4224291212 hasAuthorship W4224291212A5012092459 @default.
- W4224291212 hasAuthorship W4224291212A5018783420 @default.
- W4224291212 hasAuthorship W4224291212A5028853121 @default.
- W4224291212 hasAuthorship W4224291212A5030814799 @default.
- W4224291212 hasAuthorship W4224291212A5031767261 @default.
- W4224291212 hasAuthorship W4224291212A5036373931 @default.
- W4224291212 hasAuthorship W4224291212A5041246235 @default.
- W4224291212 hasAuthorship W4224291212A5045374257 @default.
- W4224291212 hasAuthorship W4224291212A5046427306 @default.
- W4224291212 hasAuthorship W4224291212A5046678035 @default.
- W4224291212 hasAuthorship W4224291212A5049927866 @default.
- W4224291212 hasAuthorship W4224291212A5052332289 @default.
- W4224291212 hasAuthorship W4224291212A5059828424 @default.
- W4224291212 hasAuthorship W4224291212A5060864525 @default.
- W4224291212 hasAuthorship W4224291212A5061968220 @default.
- W4224291212 hasAuthorship W4224291212A5080942529 @default.
- W4224291212 hasAuthorship W4224291212A5081510532 @default.
- W4224291212 hasAuthorship W4224291212A5087888938 @default.