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- W4224291285 abstract "Abstract 3‐Methyleneisoindolin‐1‐one units exist in many natural products and pharmaceutics. Up to now, synthesis of axially chiral 3‐methyleneisoindolin‐1‐ones has been rarely reported. Herein we disclose a chiral phosphoric acid catalyzed enantioselective condensation of 2‐acetylbenzoic acid derivatives with 2‐substituted aniline derivatives, leading to the construction of a series of novel C−N axially chiral N ‐aryl‐3‐methylene‐isoindolin‐1‐ones in moderate to good yields (up to 97%) with generally moderate enantioselectivities (up to 87% ee). In addition, the absolute configuration of one product was determined by an X‐ray crystal structural analysis. Furthermore, one product was subjected to oxidative cleavage to generate an axially chiral phthalimide." @default.
- W4224291285 created "2022-04-26" @default.
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- W4224291285 date "2022-06-20" @default.
- W4224291285 modified "2023-10-16" @default.
- W4224291285 title "Enantioselective Synthesis of Axially Chiral <i>N</i> ‐Aryl‐3‐methyleneisoindolin‐1‐ones" @default.
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- W4224291285 doi "https://doi.org/10.1002/ajoc.202200109" @default.
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