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- W4224295909 abstract "Abstract Background Invasive lobular breast carcinoma (ILC), the second most prevalent histological subtype of breast cancer, exhibits unique molecular features compared with the more common invasive ductal carcinoma (IDC). While genomic and transcriptomic features of ILC and IDC have been characterized, genome-wide chromatin accessibility pattern differences between ILC and IDC remain largely unexplored. Methods Here, we characterized tumor-intrinsic chromatin accessibility differences between ILC and IDC using primary tumors from The Cancer Genome Atlas (TCGA) breast cancer assay for transposase-accessible chromatin with sequencing (ATAC-seq) dataset. Results We identified distinct patterns of genome-wide chromatin accessibility in ILC and IDC. Inferred patient-specific transcription factor (TF) motif activities revealed regulatory differences between and within ILC and IDC tumors. EGR1, RUNX3, TP63, STAT6, SOX family, and TEAD family TFs were higher in ILC, while ATF4, PBX3, SPDEF, PITX family, and FOX family TFs were higher in IDC. Conclusions This study reveals the distinct epigenomic features of ILC and IDC and the active TFs driving cancer progression that may provide valuable information on patient prognosis." @default.
- W4224295909 created "2022-04-26" @default.
- W4224295909 creator A5020068849 @default.
- W4224295909 creator A5053167068 @default.
- W4224295909 date "2022-04-08" @default.
- W4224295909 modified "2023-10-03" @default.
- W4224295909 title "Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas" @default.
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- W4224295909 doi "https://doi.org/10.1101/2022.04.08.487589" @default.
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