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- W4224296679 abstract "Exposure to high ambient temperature is a stressor that influences both biological and behavioral functions and has been previously shown to have an extensive impact on brain structure and function. Physiological, cellular and behavioral responses to heat-stress (HS) (40–41 °C, 2 h) were evaluated in adult male Sprague-Dawley rats. The effect of HS exposure before predator-scent stress (PSS) exposure (i.e., HS preconditioning) was examined. Finally, a possible mechanism of HS-preconditioning to PSS was investigated. Immunohistochemical analyses of chosen cellular markers were performed in the hippocampus and in the hypothalamic paraventricular nucleus (PVN). Plasma corticosterone levels were evaluated, and the behavioral assessment included the elevated plus-maze (EPM) and the acoustic startle response (ASR) paradigms. Endogenous levels of heat shock protein (HSP)-70 were manipulated using an amino acid (L-glutamine) and a pharmacological agent (Doxazosin). A single exposure to an acute HS resulted in decreased body mass (BM), increased body temperature and increased corticosterone levels. Additionally, extensive cellular, but not behavioral changes were noted. HS-preconditioning provided behavioral resiliency to anxiety-like behavior associated with PSS, possibly through the induction of HSP-70. Targeting of HSP-70 is an attractive strategy for stress-related psychopathology treatment." @default.
- W4224296679 created "2022-04-26" @default.
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- W4224296679 date "2022-04-08" @default.
- W4224296679 modified "2023-09-30" @default.
- W4224296679 title "Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses" @default.
- W4224296679 cites W117431324 @default.
- W4224296679 cites W1501330475 @default.
- W4224296679 cites W1505624094 @default.
- W4224296679 cites W1599595176 @default.
- W4224296679 cites W1600738479 @default.
- W4224296679 cites W1784804311 @default.
- W4224296679 cites W1826326337 @default.
- W4224296679 cites W1891173294 @default.
- W4224296679 cites W1897887860 @default.
- W4224296679 cites W1914011667 @default.
- W4224296679 cites W1916932902 @default.
- W4224296679 cites W1965026559 @default.
- W4224296679 cites W1965144249 @default.
- W4224296679 cites W1967629035 @default.
- W4224296679 cites W1969658971 @default.
- W4224296679 cites W1976207128 @default.
- W4224296679 cites W1976491653 @default.
- W4224296679 cites W1978489370 @default.
- W4224296679 cites W1986280375 @default.
- W4224296679 cites W1988863241 @default.
- W4224296679 cites W1988954465 @default.
- W4224296679 cites W1990824309 @default.
- W4224296679 cites W1991721022 @default.
- W4224296679 cites W1993213847 @default.
- W4224296679 cites W2000997407 @default.
- W4224296679 cites W2004748291 @default.
- W4224296679 cites W2005544317 @default.
- W4224296679 cites W2005636076 @default.
- W4224296679 cites W2008620918 @default.
- W4224296679 cites W2010490939 @default.
- W4224296679 cites W2010820473 @default.
- W4224296679 cites W2015706391 @default.
- W4224296679 cites W2016233365 @default.
- W4224296679 cites W2017117197 @default.
- W4224296679 cites W2018455601 @default.
- W4224296679 cites W2026123452 @default.
- W4224296679 cites W2031502028 @default.
- W4224296679 cites W2033187357 @default.
- W4224296679 cites W2034670940 @default.
- W4224296679 cites W2037387603 @default.
- W4224296679 cites W2039352738 @default.
- W4224296679 cites W2042320381 @default.
- W4224296679 cites W2043337264 @default.
- W4224296679 cites W2048527381 @default.
- W4224296679 cites W2050021087 @default.
- W4224296679 cites W2051086354 @default.
- W4224296679 cites W2055706332 @default.
- W4224296679 cites W2056205520 @default.
- W4224296679 cites W2056449700 @default.
- W4224296679 cites W2057742382 @default.
- W4224296679 cites W2064291612 @default.
- W4224296679 cites W2066427182 @default.
- W4224296679 cites W2068519800 @default.
- W4224296679 cites W2069302954 @default.
- W4224296679 cites W2072435021 @default.
- W4224296679 cites W2077255172 @default.
- W4224296679 cites W2081188194 @default.
- W4224296679 cites W2082365607 @default.
- W4224296679 cites W2084830673 @default.
- W4224296679 cites W2085939771 @default.
- W4224296679 cites W2088919174 @default.
- W4224296679 cites W2093872961 @default.
- W4224296679 cites W2094450224 @default.
- W4224296679 cites W2094544368 @default.
- W4224296679 cites W2101736298 @default.
- W4224296679 cites W2103137967 @default.
- W4224296679 cites W2103889849 @default.
- W4224296679 cites W2109759840 @default.
- W4224296679 cites W2120868588 @default.
- W4224296679 cites W2121728427 @default.
- W4224296679 cites W2125432788 @default.
- W4224296679 cites W2129819610 @default.
- W4224296679 cites W2132539548 @default.
- W4224296679 cites W2136008463 @default.
- W4224296679 cites W2138684097 @default.
- W4224296679 cites W2139565721 @default.
- W4224296679 cites W2142076128 @default.
- W4224296679 cites W2146217294 @default.
- W4224296679 cites W2146604249 @default.
- W4224296679 cites W2148336465 @default.
- W4224296679 cites W2150736802 @default.
- W4224296679 cites W2155855405 @default.
- W4224296679 cites W2156196889 @default.
- W4224296679 cites W2163520260 @default.
- W4224296679 cites W2165300686 @default.
- W4224296679 cites W2165585062 @default.