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- W4224298081 endingPage "4547" @default.
- W4224298081 startingPage "4547" @default.
- W4224298081 abstract "Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT." @default.
- W4224298081 created "2022-04-26" @default.
- W4224298081 creator A5020106406 @default.
- W4224298081 creator A5026924923 @default.
- W4224298081 creator A5051547540 @default.
- W4224298081 creator A5082873209 @default.
- W4224298081 creator A5088475441 @default.
- W4224298081 creator A5089050927 @default.
- W4224298081 date "2022-04-20" @default.
- W4224298081 modified "2023-10-14" @default.
- W4224298081 title "The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview" @default.
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