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• W4224300152 abstract "Many immunological diseases can be treated by regulating neurobehavior, in which extracellular ATP is a vital member of endogenous danger-associated molecular pattern signaling molecule that plays a crucial part in innate neuro-related immunity. It is actively released through pannexin (Panx) and connexin (Cx) hemichannels from activated or stressed cells during inflammation, injury, or apoptosis. In addition to participating in ATP release, Panxs and Cxs also have crucial immune functions. In this study, pannexin1, three connexin32 isoforms and connexin43 were identified and characterized in spotted sea bass ( Lateolabrax maculatus ), which were named Lm Panx1, Lm Cx32.2, Lm Cx32.3, Lm Cx32.7, and Lm Cx43. Their similar topological structures were discovered by sequence analysis: a relatively unconserved C-terminal region and four highly conserved transmembrane (TM) domains, and so on. Each extracellular (ECL) region of Panx1 has two conserved cysteine residues. Unlike Panx1, each ECL region of Cx32 and Cx43 contains three conserved cysteine residues, forming two conserved motifs: CX 6 CX 3 C motif in ECL1 and CX 4 CX 5 C motif in ECL2. Furthermore, Panx1 and Cx43 share similar genomic organization and synteny with their counterparts in selected vertebrates. Cx32 and CX43 were located in the same locus in fish, but diverged into two loci from amphibian. Moreover, despite varying expression levels, the identified genes were constitutively expressed in all examined tissues. All genes were upregulated by PAMP [lipopolysaccharide and poly(I:C)] stimulation or bacterial infection in vivo and in vitro , but they were downregulated in the brain at 6 or 12 h after stimulation. Especially, the three Lm Cx32 isoforms and Lm Cx43 were upregulated by ATP stimulation in primary head kidney leukocytes; however, downregulation of Lm Cx32.3 and Lm Cx43 expression were noted at 12 h. Conversely, ATP treatment inhibited the expression of Lm Panx1. Importantly, we showed that the spotted sea bass Panx1, Cx43, and Cx32 were localized on the cellular membrane and involved in inflammation-induced ATP release. Taken together, our results demonstrated that Panx1, Cx32, and Cx43 are important neuro-related immune response genes involved in inflammation-induced ATP release." @default.
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• W4224300152 date "2022-04-19" @default.
• W4224300152 modified "2023-10-03" @default.
• W4224300152 title "Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release" @default.
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• W4224300152 doi "https://doi.org/10.3389/fimmu.2022.870679" @default.
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