FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224304908> ?p ?o ?g. }

• W4224304908 endingPage "112964" @default.
• W4224304908 startingPage "112964" @default.
• W4224304908 abstract "Realgar, as a commonly used traditional Chinese medicine, exerts both pharmacological and biological effects. However, the mechanism by which it causes nervous system injury remains unclear. This study aimed to elucidate the specific mechanism underlying the hippocampal neurotoxicity caused by realgar. Nrf2 is an important receptor of exogenous toxic substances and oxidative stress. We utilized a p38-specific inhibitor (SB20358), ERK1/2-specific inhibitor (PD98059), JNK-specific inhibitor (SP600125) and AKT-specific inhibitor (LY249002) to establish the corresponding animal models and explore how realgar activates Nrf2. We established an Nrf2-shRNA gene silencing model in rats and an autophagy-specific inhibitor treatment model to further explore realgar-induced neurotoxicity and the role of Nrf2 in realgar-induced damage to the hippocampus. The results showed that realgar passed through the blood–brain barrier and accumulated in brain tissue to induce central nervous system toxicity. The specific mechanism was that realgar activated MAPKs and AKT signaling molecules to activate the Nrf2-Keap1-p62 positive feedback signaling axis, induced abnormal autophagy initiation and degradation, and promoted oxidative damage and apoptosis in neurons. Effective measures should be taken to prevent and control the arsenic poisoning caused by realgar in the early stage, and this study provides a theoretical and practical basis for the rational use of drugs in the clinic." @default.
• W4224304908 created "2022-04-26" @default.
• W4224304908 creator A5052737766 @default.
• W4224304908 creator A5071146678 @default.
• W4224304908 creator A5090341278 @default.
• W4224304908 creator A5091185492 @default.
• W4224304908 date "2022-06-01" @default.
• W4224304908 modified "2023-10-04" @default.
• W4224304908 title "Realgar facilitates the Nrf2-Keap1-p62 positive feedback signaling axis via MAPKs and AKT to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus" @default.
• W4224304908 cites W1942214720 @default.
• W4224304908 cites W1966047754 @default.
• W4224304908 cites W2009659607 @default.
• W4224304908 cites W2023598683 @default.
• W4224304908 cites W2037382204 @default.
• W4224304908 cites W2042938039 @default.
• W4224304908 cites W2052853635 @default.
• W4224304908 cites W2055971882 @default.
• W4224304908 cites W2102354517 @default.
• W4224304908 cites W2117800935 @default.
• W4224304908 cites W2301334697 @default.
• W4224304908 cites W2325707043 @default.
• W4224304908 cites W2559923006 @default.
• W4224304908 cites W2571523888 @default.
• W4224304908 cites W2591051430 @default.
• W4224304908 cites W2770432229 @default.
• W4224304908 cites W2773258360 @default.
• W4224304908 cites W2775058564 @default.
• W4224304908 cites W2792676320 @default.
• W4224304908 cites W2888481567 @default.
• W4224304908 cites W2889401286 @default.
• W4224304908 cites W2894123970 @default.
• W4224304908 cites W2898919023 @default.
• W4224304908 cites W2899645375 @default.
• W4224304908 cites W2902644109 @default.
• W4224304908 cites W2909477364 @default.
• W4224304908 cites W2945779890 @default.
• W4224304908 cites W2980690609 @default.
• W4224304908 cites W2990354816 @default.
• W4224304908 cites W3015996453 @default.
• W4224304908 cites W3107572653 @default.
• W4224304908 cites W3109540700 @default.
• W4224304908 cites W3138060333 @default.
• W4224304908 cites W3160613912 @default.
• W4224304908 cites W3197033234 @default.
• W4224304908 cites W4211045864 @default.
• W4224304908 cites W840875033 @default.
• W4224304908 doi "https://doi.org/10.1016/j.biopha.2022.112964" @default.
• W4224304908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35461089" @default.
• W4224304908 hasPublicationYear "2022" @default.
• W4224304908 type Work @default.
• W4224304908 citedByCount "4" @default.
• W4224304908 countsByYear W42243049082022 @default.
• W4224304908 countsByYear W42243049082023 @default.
• W4224304908 crossrefType "journal-article" @default.
• W4224304908 hasAuthorship W4224304908A5052737766 @default.
• W4224304908 hasAuthorship W4224304908A5071146678 @default.
• W4224304908 hasAuthorship W4224304908A5090341278 @default.
• W4224304908 hasAuthorship W4224304908A5091185492 @default.
• W4224304908 hasBestOaLocation W42243049081 @default.
• W4224304908 hasConcept C104317684 @default.
• W4224304908 hasConcept C126322002 @default.
• W4224304908 hasConcept C148762608 @default.
• W4224304908 hasConcept C169760540 @default.
• W4224304908 hasConcept C185592680 @default.
• W4224304908 hasConcept C190283241 @default.
• W4224304908 hasConcept C199289684 @default.
• W4224304908 hasConcept C203522944 @default.
• W4224304908 hasConcept C2776151105 @default.
• W4224304908 hasConcept C2776529522 @default.
• W4224304908 hasConcept C2778548315 @default.
• W4224304908 hasConcept C2779491297 @default.
• W4224304908 hasConcept C29730261 @default.
• W4224304908 hasConcept C51551487 @default.
• W4224304908 hasConcept C55493867 @default.
• W4224304908 hasConcept C57074206 @default.
• W4224304908 hasConcept C62478195 @default.
• W4224304908 hasConcept C71924100 @default.
• W4224304908 hasConcept C75217442 @default.
• W4224304908 hasConcept C86339819 @default.
• W4224304908 hasConcept C86554907 @default.
• W4224304908 hasConcept C86803240 @default.
• W4224304908 hasConcept C95444343 @default.
• W4224304908 hasConcept C98274493 @default.
• W4224304908 hasConceptScore W4224304908C104317684 @default.
• W4224304908 hasConceptScore W4224304908C126322002 @default.
• W4224304908 hasConceptScore W4224304908C148762608 @default.
• W4224304908 hasConceptScore W4224304908C169760540 @default.
• W4224304908 hasConceptScore W4224304908C185592680 @default.
• W4224304908 hasConceptScore W4224304908C190283241 @default.
• W4224304908 hasConceptScore W4224304908C199289684 @default.
• W4224304908 hasConceptScore W4224304908C203522944 @default.
• W4224304908 hasConceptScore W4224304908C2776151105 @default.
• W4224304908 hasConceptScore W4224304908C2776529522 @default.
• W4224304908 hasConceptScore W4224304908C2778548315 @default.
• W4224304908 hasConceptScore W4224304908C2779491297 @default.
• W4224304908 hasConceptScore W4224304908C29730261 @default.
• W4224304908 hasConceptScore W4224304908C51551487 @default.
• W4224304908 hasConceptScore W4224304908C55493867 @default.

• next