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- W4224306507 abstract "The major heat shock protein Hsp70 forms a complex with a scaffold protein Bag3 that links it to components of signaling pathways. Via these interactions, the Hsp70-Bag3 module functions as a proteotoxicity sensor that controls cell signaling. Here, to search for pathways regulated by the complex, we utilized JG-98, an allosteric inhibitor of Hsp70 that blocks its interaction with Bag3. RNAseq followed by the pathway analysis indicated that several signaling pathways including UPR were activated by JG-98. Surprisingly, only the eIF2α-associated branch of the UPR was activated, while other UPR branches were not induced, suggesting that the response was unrelated to the ER proteotoxicity and ER-associated kinase PERK1. Indeed, induction of the UPR genes under these conditions was driven by a distinct eIF2α kinase HRI. Hsp70-Bag3 directly interacted with HRI and regulated eIF2α phosphorylation upon cytoplasmic proteotoxicity. Therefore, cytosolic proteotoxicity can activate certain UPR genes via Hsp70-Bag3-HRI-eIF2α axis." @default.
- W4224306507 created "2022-04-26" @default.
- W4224306507 creator A5009949681 @default.
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- W4224306507 creator A5027850583 @default.
- W4224306507 creator A5072969556 @default.
- W4224306507 creator A5084135451 @default.
- W4224306507 date "2022-05-01" @default.
- W4224306507 modified "2023-10-15" @default.
- W4224306507 title "Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module" @default.
- W4224306507 cites W1968727357 @default.
- W4224306507 cites W1968727721 @default.
- W4224306507 cites W1973393948 @default.
- W4224306507 cites W1977603207 @default.
- W4224306507 cites W1986887896 @default.
- W4224306507 cites W1987875115 @default.
- W4224306507 cites W1991999080 @default.
- W4224306507 cites W1995486038 @default.
- W4224306507 cites W1995708787 @default.
- W4224306507 cites W2001399725 @default.
- W4224306507 cites W2001569984 @default.
- W4224306507 cites W2007594173 @default.
- W4224306507 cites W2010301504 @default.
- W4224306507 cites W2010305557 @default.
- W4224306507 cites W2016545708 @default.
- W4224306507 cites W2019500428 @default.
- W4224306507 cites W2023215532 @default.
- W4224306507 cites W2025483501 @default.
- W4224306507 cites W2034030812 @default.
- W4224306507 cites W2036853011 @default.
- W4224306507 cites W2039820208 @default.
- W4224306507 cites W2040640278 @default.
- W4224306507 cites W2056036930 @default.
- W4224306507 cites W2056282383 @default.
- W4224306507 cites W2056331158 @default.
- W4224306507 cites W2059606129 @default.
- W4224306507 cites W2063491301 @default.
- W4224306507 cites W2063956958 @default.
- W4224306507 cites W2070529078 @default.
- W4224306507 cites W2075701459 @default.
- W4224306507 cites W2085487477 @default.
- W4224306507 cites W2089375954 @default.
- W4224306507 cites W2090499267 @default.
- W4224306507 cites W2092365242 @default.
- W4224306507 cites W2104704977 @default.
- W4224306507 cites W2104935252 @default.
- W4224306507 cites W2104958095 @default.
- W4224306507 cites W2108736984 @default.
- W4224306507 cites W2114104545 @default.
- W4224306507 cites W2115914985 @default.
- W4224306507 cites W2120736516 @default.
- W4224306507 cites W2123737072 @default.
- W4224306507 cites W2128818088 @default.
- W4224306507 cites W2130116522 @default.
- W4224306507 cites W2131632095 @default.
- W4224306507 cites W2139529165 @default.
- W4224306507 cites W2146512944 @default.
- W4224306507 cites W2160269498 @default.
- W4224306507 cites W2161696113 @default.
- W4224306507 cites W2162066969 @default.
- W4224306507 cites W2162437451 @default.
- W4224306507 cites W2162483267 @default.
- W4224306507 cites W2171258641 @default.
- W4224306507 cites W2192080449 @default.
- W4224306507 cites W2346154457 @default.
- W4224306507 cites W2514978556 @default.
- W4224306507 cites W2517203221 @default.
- W4224306507 cites W2518959324 @default.
- W4224306507 cites W2533460394 @default.
- W4224306507 cites W2725496298 @default.
- W4224306507 cites W2768120512 @default.
- W4224306507 cites W2785892239 @default.
- W4224306507 cites W2791155359 @default.
- W4224306507 cites W2810892605 @default.
- W4224306507 cites W2824490147 @default.
- W4224306507 cites W2829023813 @default.
- W4224306507 cites W2911384175 @default.
- W4224306507 cites W2922202142 @default.
- W4224306507 cites W2969864766 @default.
- W4224306507 cites W2975923342 @default.
- W4224306507 cites W3009541903 @default.
- W4224306507 cites W3010628223 @default.
- W4224306507 cites W3081418184 @default.
- W4224306507 cites W3087454557 @default.
- W4224306507 cites W3096817529 @default.
- W4224306507 cites W3098005452 @default.
- W4224306507 cites W3153454140 @default.
- W4224306507 cites W3211553508 @default.
- W4224306507 cites W4254720972 @default.
- W4224306507 doi "https://doi.org/10.1016/j.isci.2022.104282" @default.
- W4224306507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35573186" @default.
- W4224306507 hasPublicationYear "2022" @default.
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