FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224306795> ?p ?o ?g. }

• W4224306795 endingPage "14477" @default.
• W4224306795 startingPage "14465" @default.
• W4224306795 abstract "A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds." @default.
• W4224306795 created "2022-04-26" @default.
• W4224306795 creator A5027812851 @default.
• W4224306795 creator A5027863157 @default.
• W4224306795 creator A5030156613 @default.
• W4224306795 creator A5043441484 @default.
• W4224306795 creator A5046225712 @default.
• W4224306795 creator A5054769205 @default.
• W4224306795 creator A5058107333 @default.
• W4224306795 creator A5074002905 @default.
• W4224306795 creator A5080607033 @default.
• W4224306795 creator A5084122867 @default.
• W4224306795 creator A5084347338 @default.
• W4224306795 creator A5087683685 @default.
• W4224306795 date "2022-04-18" @default.
• W4224306795 modified "2023-10-17" @default.
• W4224306795 title "Network Pharmacology with Experimental Investigation of the Mechanisms of <i>Rhizoma Polygonati</i> against Prostate Cancer with Additional Herbzymatic Activity" @default.
• W4224306795 cites W1966203663 @default.
• W4224306795 cites W2003404985 @default.
• W4224306795 cites W2023891996 @default.
• W4224306795 cites W2027847170 @default.
• W4224306795 cites W2066554820 @default.
• W4224306795 cites W2121604817 @default.
• W4224306795 cites W2143253449 @default.
• W4224306795 cites W2159675211 @default.
• W4224306795 cites W2288903023 @default.
• W4224306795 cites W2438423318 @default.
• W4224306795 cites W2532467030 @default.
• W4224306795 cites W2726476665 @default.
• W4224306795 cites W2754926053 @default.
• W4224306795 cites W2765777509 @default.
• W4224306795 cites W2766678037 @default.
• W4224306795 cites W2775058090 @default.
• W4224306795 cites W2786709017 @default.
• W4224306795 cites W2791372168 @default.
• W4224306795 cites W2799620759 @default.
• W4224306795 cites W2900569176 @default.
• W4224306795 cites W2902263717 @default.
• W4224306795 cites W2944545583 @default.
• W4224306795 cites W2946917215 @default.
• W4224306795 cites W2947362695 @default.
• W4224306795 cites W2954704722 @default.
• W4224306795 cites W2970821085 @default.
• W4224306795 cites W2986489178 @default.
• W4224306795 cites W3000830969 @default.
• W4224306795 cites W3006394629 @default.
• W4224306795 cites W3037348089 @default.
• W4224306795 cites W3048491217 @default.
• W4224306795 cites W3083789602 @default.
• W4224306795 cites W3086450486 @default.
• W4224306795 cites W3088177554 @default.
• W4224306795 cites W3090583683 @default.
• W4224306795 cites W3097870112 @default.
• W4224306795 cites W3105134098 @default.
• W4224306795 cites W3108860514 @default.
• W4224306795 cites W3120352129 @default.
• W4224306795 cites W3120756278 @default.
• W4224306795 cites W3126358800 @default.
• W4224306795 cites W3133611223 @default.
• W4224306795 cites W3161470636 @default.
• W4224306795 cites W4206938971 @default.
• W4224306795 doi "https://doi.org/10.1021/acsomega.1c03018" @default.
• W4224306795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35531567" @default.
• W4224306795 hasPublicationYear "2022" @default.
• W4224306795 type Work @default.
• W4224306795 citedByCount "6" @default.
• W4224306795 countsByYear W42243067952022 @default.
• W4224306795 countsByYear W42243067952023 @default.
• W4224306795 crossrefType "journal-article" @default.
• W4224306795 hasAuthorship W4224306795A5027812851 @default.
• W4224306795 hasAuthorship W4224306795A5027863157 @default.
• W4224306795 hasAuthorship W4224306795A5030156613 @default.
• W4224306795 hasAuthorship W4224306795A5043441484 @default.
• W4224306795 hasAuthorship W4224306795A5046225712 @default.
• W4224306795 hasAuthorship W4224306795A5054769205 @default.
• W4224306795 hasAuthorship W4224306795A5058107333 @default.
• W4224306795 hasAuthorship W4224306795A5074002905 @default.
• W4224306795 hasAuthorship W4224306795A5080607033 @default.
• W4224306795 hasAuthorship W4224306795A5084122867 @default.
• W4224306795 hasAuthorship W4224306795A5084347338 @default.
• W4224306795 hasAuthorship W4224306795A5087683685 @default.
• W4224306795 hasBestOaLocation W42243067952 @default.
• W4224306795 hasConcept C121608353 @default.
• W4224306795 hasConcept C126322002 @default.
• W4224306795 hasConcept C184235292 @default.
• W4224306795 hasConcept C185592680 @default.
• W4224306795 hasConcept C190283241 @default.
• W4224306795 hasConcept C2776235491 @default.
• W4224306795 hasConcept C2780192828 @default.
• W4224306795 hasConcept C502942594 @default.
• W4224306795 hasConcept C55493867 @default.
• W4224306795 hasConcept C57074206 @default.
• W4224306795 hasConcept C71924100 @default.
• W4224306795 hasConcept C75217442 @default.
• W4224306795 hasConcept C86554907 @default.
• W4224306795 hasConcept C98274493 @default.
• W4224306795 hasConceptScore W4224306795C121608353 @default.
• W4224306795 hasConceptScore W4224306795C126322002 @default.

• next