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• W4224307100 abstract "<sec> <title>BACKGROUND</title> The current COVID-19 pandemic is affecting the life of many people worldwide and although the search and application of vaccines have made fast progress, there are currently only few medications available for risk patients or advanced stages of the disease. Although the predominant Omikron mutation seems to be more harmless we don't know today which new mutations will emerge in the future. </sec> <sec> <title>OBJECTIVE</title> The objective of this study was to explore if antiviral photodynamic therapy using Riboflavin (Vitamin B2) as photosensitizer in combination with blue and ultaviolet -A light for stimulation could be effective in early stages of the disease for quick reduction of viral load and to prevent the transition of the infection into advanced stages. </sec> <sec> <title>METHODS</title> This paper explores a new treatment system with a laser/LED treatment device combined with blue and UVA light therapy. This interventional, non-randomised study involved 140 subjects. Participants were allocated to receive either PDT plus daily testing for 5 days or to receive conventional care plus testing. The viral load and clinical symptoms were measured at the start of the study and after 24, 48, 72, 96, 120 and 168 hours </sec> <sec> <title>RESULTS</title> There was a difference of 6.68 threshold cycles in the mean viral load, with a confidence interval of [5.2; 8.17]. Welch’s t-test for two samples indicated this difference was significant (p < 0.01). The same test showed that the difference in the means of the control group was not significant. </sec> <sec> <title>CONCLUSIONS</title> PDT decreases viral load in patients in early stages of COVID-19. </sec> <sec> <title>CLINICALTRIAL</title> ISRCTN10839729 https://doi.org/10.1186/ISRCTN10839729 </sec>" @default.
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• W4224307100 date "2022-04-17" @default.
• W4224307100 modified "2023-10-16" @default.
• W4224307100 title "Successful reduction of SARS-CoV-2 Viral Load by Photodynamic Therapy(PDT) Verified by QPCR, A Novel Approach in Treating Patients in Early Infection Stages (Preprint)" @default.
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• W4224307100 doi "https://doi.org/10.2196/preprints.38421" @default.
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