Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224307251> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4224307251 endingPage "e246281" @default.
- W4224307251 startingPage "e246281" @default.
- W4224307251 abstract "A male child presented initially well with a mixed nephrotic-nephritic syndrome and was commenced on standard high-dose oral corticosteroids. Clinical deterioration occurred 3 weeks later with rapidly progressing renal dysfunction, seizures and diminished urinary output, requiring renal replacement therapy. Once stabilised, renal biopsy demonstrated mesangial and capillary C3, minimal IgG deposition, with mesangial electron dense deposits felt consistent with postinfectious glomerulonephritis or C3 glomerulopathy. Further investigations identified circulating autoantibody directed against factor H, as a plausible aetiology of the membranoproliferative glomerulonephritis (MPGN). Treatment with rituximab and mycophenolate mofetil was associated with a reduction in antibody titres and a concurrent reduction in proteinuria and normalisation of renal function.Subsequent monitoring of antibody titres prompted further administrations of rituximab, with reduction in titres demonstrated after repeat doses. Atypical presentations or complications of nephrotic syndrome or MPGN should prompt detailed investigations for the cause with consideration of antifactor H antibodies." @default.
- W4224307251 created "2022-04-26" @default.
- W4224307251 creator A5018522957 @default.
- W4224307251 creator A5030805478 @default.
- W4224307251 creator A5038407278 @default.
- W4224307251 creator A5040698907 @default.
- W4224307251 date "2022-04-01" @default.
- W4224307251 modified "2023-10-16" @default.
- W4224307251 title "Use of a B-cell depleting regimen for antifactor H autoantibody-mediated membranoproliferative glomerulonephritis in a paediatric patient" @default.
- W4224307251 cites W1535259997 @default.
- W4224307251 cites W1563349777 @default.
- W4224307251 cites W1707478454 @default.
- W4224307251 cites W1980493655 @default.
- W4224307251 cites W2036436658 @default.
- W4224307251 cites W2054101977 @default.
- W4224307251 cites W2074286693 @default.
- W4224307251 cites W2076848429 @default.
- W4224307251 cites W2118296436 @default.
- W4224307251 cites W2150676169 @default.
- W4224307251 cites W2154607428 @default.
- W4224307251 cites W2467831176 @default.
- W4224307251 cites W2484733150 @default.
- W4224307251 cites W2565152113 @default.
- W4224307251 cites W2897972799 @default.
- W4224307251 cites W2914604561 @default.
- W4224307251 cites W3188600119 @default.
- W4224307251 cites W4236132412 @default.
- W4224307251 cites W4241456778 @default.
- W4224307251 doi "https://doi.org/10.1136/bcr-2021-246281" @default.
- W4224307251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35444020" @default.
- W4224307251 hasPublicationYear "2022" @default.
- W4224307251 type Work @default.
- W4224307251 citedByCount "1" @default.
- W4224307251 countsByYear W42243072512023 @default.
- W4224307251 crossrefType "journal-article" @default.
- W4224307251 hasAuthorship W4224307251A5018522957 @default.
- W4224307251 hasAuthorship W4224307251A5030805478 @default.
- W4224307251 hasAuthorship W4224307251A5038407278 @default.
- W4224307251 hasAuthorship W4224307251A5040698907 @default.
- W4224307251 hasBestOaLocation W42243072512 @default.
- W4224307251 hasConcept C126322002 @default.
- W4224307251 hasConcept C159641895 @default.
- W4224307251 hasConcept C159654299 @default.
- W4224307251 hasConcept C163764329 @default.
- W4224307251 hasConcept C203014093 @default.
- W4224307251 hasConcept C2778930706 @default.
- W4224307251 hasConcept C2779147130 @default.
- W4224307251 hasConcept C2780091579 @default.
- W4224307251 hasConcept C2780199430 @default.
- W4224307251 hasConcept C2780368995 @default.
- W4224307251 hasConcept C2780653079 @default.
- W4224307251 hasConcept C2780688133 @default.
- W4224307251 hasConcept C2781036514 @default.
- W4224307251 hasConcept C2781087799 @default.
- W4224307251 hasConcept C71924100 @default.
- W4224307251 hasConcept C90924648 @default.
- W4224307251 hasConceptScore W4224307251C126322002 @default.
- W4224307251 hasConceptScore W4224307251C159641895 @default.
- W4224307251 hasConceptScore W4224307251C159654299 @default.
- W4224307251 hasConceptScore W4224307251C163764329 @default.
- W4224307251 hasConceptScore W4224307251C203014093 @default.
- W4224307251 hasConceptScore W4224307251C2778930706 @default.
- W4224307251 hasConceptScore W4224307251C2779147130 @default.
- W4224307251 hasConceptScore W4224307251C2780091579 @default.
- W4224307251 hasConceptScore W4224307251C2780199430 @default.
- W4224307251 hasConceptScore W4224307251C2780368995 @default.
- W4224307251 hasConceptScore W4224307251C2780653079 @default.
- W4224307251 hasConceptScore W4224307251C2780688133 @default.
- W4224307251 hasConceptScore W4224307251C2781036514 @default.
- W4224307251 hasConceptScore W4224307251C2781087799 @default.
- W4224307251 hasConceptScore W4224307251C71924100 @default.
- W4224307251 hasConceptScore W4224307251C90924648 @default.
- W4224307251 hasIssue "4" @default.
- W4224307251 hasLocation W42243072511 @default.
- W4224307251 hasLocation W42243072512 @default.
- W4224307251 hasLocation W42243072513 @default.
- W4224307251 hasOpenAccess W4224307251 @default.
- W4224307251 hasPrimaryLocation W42243072511 @default.
- W4224307251 hasRelatedWork W1989171344 @default.
- W4224307251 hasRelatedWork W2116977443 @default.
- W4224307251 hasRelatedWork W2265281284 @default.
- W4224307251 hasRelatedWork W2353297478 @default.
- W4224307251 hasRelatedWork W2364768418 @default.
- W4224307251 hasRelatedWork W2378702056 @default.
- W4224307251 hasRelatedWork W2384732301 @default.
- W4224307251 hasRelatedWork W2735726711 @default.
- W4224307251 hasRelatedWork W3034156449 @default.
- W4224307251 hasRelatedWork W4224307251 @default.
- W4224307251 hasVolume "15" @default.
- W4224307251 isParatext "false" @default.
- W4224307251 isRetracted "false" @default.
- W4224307251 workType "article" @default.