Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224307427> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4224307427 abstract "Poly (ADP-ribose) polymerase (PARP) is responsible for the synthesis of ADP-ribose polymers, which are involved in a wide range of cellular processes such as preservation of genome integrity, DNA damage signaling and repair, molecular switch between distinct cell death pathways and cell cycle progression. Previously, we demonstrated that the only PARP present in T. cruzi migrates to the nucleus upon genotoxic stimulus. In this work, we identify the N-terminal domain as being sufficient for TcPARP nuclear localization and describe for the first time that TcPARP is enriched in the parasite nucleolus. We also describe that TcPARP is present in a thread that connects two dividing nuclei and co-localizes with nucleolar material and microtubules. Furthermore, ADP-ribose polymers could also be detected in this wire during mitosis. These findings represent a first approach to new potential TcPARP functions inside the nucleus and will help understand its role well beyond the largely described DNA damage response protein in trypanosomatids." @default.
- W4224307427 created "2022-04-26" @default.
- W4224307427 creator A5012451205 @default.
- W4224307427 creator A5081337119 @default.
- W4224307427 creator A5091574168 @default.
- W4224307427 date "2022-04-07" @default.
- W4224307427 modified "2023-10-15" @default.
- W4224307427 title "<i>Trypanosoma cruzi</i> PARP is enriched in the nucleolus and is present in a thread connecting nuclei during mitosis." @default.
- W4224307427 doi "https://doi.org/10.1101/2022.04.07.487537" @default.
- W4224307427 hasPublicationYear "2022" @default.
- W4224307427 type Work @default.
- W4224307427 citedByCount "0" @default.
- W4224307427 crossrefType "posted-content" @default.
- W4224307427 hasAuthorship W4224307427A5012451205 @default.
- W4224307427 hasAuthorship W4224307427A5081337119 @default.
- W4224307427 hasAuthorship W4224307427A5091574168 @default.
- W4224307427 hasBestOaLocation W42243074271 @default.
- W4224307427 hasConcept C134935766 @default.
- W4224307427 hasConcept C143425029 @default.
- W4224307427 hasConcept C182979987 @default.
- W4224307427 hasConcept C183873130 @default.
- W4224307427 hasConcept C2780723820 @default.
- W4224307427 hasConcept C54355233 @default.
- W4224307427 hasConcept C552990157 @default.
- W4224307427 hasConcept C82381507 @default.
- W4224307427 hasConcept C86803240 @default.
- W4224307427 hasConcept C93304396 @default.
- W4224307427 hasConcept C95444343 @default.
- W4224307427 hasConceptScore W4224307427C134935766 @default.
- W4224307427 hasConceptScore W4224307427C143425029 @default.
- W4224307427 hasConceptScore W4224307427C182979987 @default.
- W4224307427 hasConceptScore W4224307427C183873130 @default.
- W4224307427 hasConceptScore W4224307427C2780723820 @default.
- W4224307427 hasConceptScore W4224307427C54355233 @default.
- W4224307427 hasConceptScore W4224307427C552990157 @default.
- W4224307427 hasConceptScore W4224307427C82381507 @default.
- W4224307427 hasConceptScore W4224307427C86803240 @default.
- W4224307427 hasConceptScore W4224307427C93304396 @default.
- W4224307427 hasConceptScore W4224307427C95444343 @default.
- W4224307427 hasLocation W42243074271 @default.
- W4224307427 hasOpenAccess W4224307427 @default.
- W4224307427 hasPrimaryLocation W42243074271 @default.
- W4224307427 hasRelatedWork W1977315934 @default.
- W4224307427 hasRelatedWork W2004103693 @default.
- W4224307427 hasRelatedWork W2013881430 @default.
- W4224307427 hasRelatedWork W2043680807 @default.
- W4224307427 hasRelatedWork W2061596601 @default.
- W4224307427 hasRelatedWork W2065107886 @default.
- W4224307427 hasRelatedWork W2135956341 @default.
- W4224307427 hasRelatedWork W2801224314 @default.
- W4224307427 hasRelatedWork W2888493183 @default.
- W4224307427 hasRelatedWork W2906776957 @default.
- W4224307427 isParatext "false" @default.
- W4224307427 isRetracted "false" @default.
- W4224307427 workType "article" @default.