FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224307910> ?p ?o ?g. }

• W4224307910 endingPage "751" @default.
• W4224307910 startingPage "751" @default.
• W4224307910 abstract "Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an inhibitor of de novo purine synthesis, attenuates stemness of MTAP-deficient GBM cells. This ALA-induced reduction in stemness is mediated in part by compromised mitochondrial function, highlighted by ALA-induced elimination of mitochondrial spare respiratory capacity. Notably, these effects of ALA are apparent even when the treatment was transient and with a low dose. Finally, in agreement with diminished stemness and compromised mitochondrial function, we show that ALA sensitizes GBM cells to temozolomide (TMZ) in vitro and in an orthotopic GBM model. Collectively, these results identify purine supply as an essential component in maintaining mitochondrial function in GBM cells and highlight a critical role of mitochondrial function in sustaining GBM stemness. We propose that purine synthesis inhibition can be beneficial in combination with the standard of care for MTAP-deficient GBMs, and that it may be feasible to achieve this benefit without inflicting major toxicity." @default.
• W4224307910 created "2022-04-26" @default.
• W4224307910 creator A5003919594 @default.
• W4224307910 creator A5021569860 @default.
• W4224307910 creator A5031481251 @default.
• W4224307910 creator A5034690648 @default.
• W4224307910 creator A5038247833 @default.
• W4224307910 creator A5048382247 @default.
• W4224307910 creator A5059485677 @default.
• W4224307910 creator A5062250223 @default.
• W4224307910 creator A5089580977 @default.
• W4224307910 date "2022-03-23" @default.
• W4224307910 modified "2023-10-01" @default.
• W4224307910 title "Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells" @default.
• W4224307910 cites W1678211544 @default.
• W4224307910 cites W1902577542 @default.
• W4224307910 cites W1995596330 @default.
• W4224307910 cites W1997099893 @default.
• W4224307910 cites W1998628096 @default.
• W4224307910 cites W2000647702 @default.
• W4224307910 cites W2001375177 @default.
• W4224307910 cites W2001544973 @default.
• W4224307910 cites W2018641577 @default.
• W4224307910 cites W2047073318 @default.
• W4224307910 cites W2060551076 @default.
• W4224307910 cites W2089756467 @default.
• W4224307910 cites W2090057452 @default.
• W4224307910 cites W2112452933 @default.
• W4224307910 cites W2130410032 @default.
• W4224307910 cites W2135925682 @default.
• W4224307910 cites W2148977460 @default.
• W4224307910 cites W2159600984 @default.
• W4224307910 cites W2167414381 @default.
• W4224307910 cites W2344726805 @default.
• W4224307910 cites W2392045628 @default.
• W4224307910 cites W2465689872 @default.
• W4224307910 cites W2602955340 @default.
• W4224307910 cites W2781315337 @default.
• W4224307910 cites W2791628792 @default.
• W4224307910 cites W2942790831 @default.
• W4224307910 cites W2965528058 @default.
• W4224307910 cites W3046797242 @default.
• W4224307910 cites W3097893800 @default.
• W4224307910 cites W3113187692 @default.
• W4224307910 cites W3113882127 @default.
• W4224307910 cites W3137453670 @default.
• W4224307910 cites W3155020733 @default.
• W4224307910 cites W4234865248 @default.
• W4224307910 cites W2102954649 @default.
• W4224307910 doi "https://doi.org/10.3390/biomedicines10040751" @default.
• W4224307910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35453502" @default.
• W4224307910 hasPublicationYear "2022" @default.
• W4224307910 type Work @default.
• W4224307910 citedByCount "5" @default.
• W4224307910 countsByYear W42243079102022 @default.
• W4224307910 countsByYear W42243079102023 @default.
• W4224307910 crossrefType "journal-article" @default.
• W4224307910 hasAuthorship W4224307910A5003919594 @default.
• W4224307910 hasAuthorship W4224307910A5021569860 @default.
• W4224307910 hasAuthorship W4224307910A5031481251 @default.
• W4224307910 hasAuthorship W4224307910A5034690648 @default.
• W4224307910 hasAuthorship W4224307910A5038247833 @default.
• W4224307910 hasAuthorship W4224307910A5048382247 @default.
• W4224307910 hasAuthorship W4224307910A5059485677 @default.
• W4224307910 hasAuthorship W4224307910A5062250223 @default.
• W4224307910 hasAuthorship W4224307910A5089580977 @default.
• W4224307910 hasBestOaLocation W42243079101 @default.
• W4224307910 hasConcept C181199279 @default.
• W4224307910 hasConcept C2776194525 @default.
• W4224307910 hasConcept C2776476023 @default.
• W4224307910 hasConcept C2777389519 @default.
• W4224307910 hasConcept C28328180 @default.
• W4224307910 hasConcept C28859421 @default.
• W4224307910 hasConcept C502942594 @default.
• W4224307910 hasConcept C55493867 @default.
• W4224307910 hasConcept C86803240 @default.
• W4224307910 hasConcept C95444343 @default.
• W4224307910 hasConceptScore W4224307910C181199279 @default.
• W4224307910 hasConceptScore W4224307910C2776194525 @default.
• W4224307910 hasConceptScore W4224307910C2776476023 @default.
• W4224307910 hasConceptScore W4224307910C2777389519 @default.
• W4224307910 hasConceptScore W4224307910C28328180 @default.
• W4224307910 hasConceptScore W4224307910C28859421 @default.
• W4224307910 hasConceptScore W4224307910C502942594 @default.
• W4224307910 hasConceptScore W4224307910C55493867 @default.
• W4224307910 hasConceptScore W4224307910C86803240 @default.
• W4224307910 hasConceptScore W4224307910C95444343 @default.
• W4224307910 hasFunder F4320337359 @default.
• W4224307910 hasIssue "4" @default.
• W4224307910 hasLocation W42243079101 @default.
• W4224307910 hasLocation W42243079102 @default.
• W4224307910 hasLocation W42243079103 @default.
• W4224307910 hasOpenAccess W4224307910 @default.
• W4224307910 hasPrimaryLocation W42243079101 @default.
• W4224307910 hasRelatedWork W2024344351 @default.
• W4224307910 hasRelatedWork W2040079807 @default.
• W4224307910 hasRelatedWork W2118732639 @default.
• W4224307910 hasRelatedWork W2145294892 @default.

• next