Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224312285> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4224312285 abstract "Abstract CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has an inherent ability to promote wound healing; wounds close and re-epithelialise faster in CAR-treated mice. CAR promotes keratinocyte migration in vitro . Syndecan-4 (SDC4) is a heparan sulfate proteoglycan that regulates cell migration and is crucial for wound healing. We report that SDC4 expression is restricted to epidermis and blood vessels in skin wounds. SDC4 regulates cell binding and internalisation of CAR peptide and CAR-mediated cytoskeletal remodelling. CAR induces SDC4-dependent activation of the small GTPase Arf6 (ARF6) and promotes SDC4- and ARF6-mediated keratinocyte migration. Finally, we show that genetic ablation of SDC4 in mice eliminates CAR-induced wound re-epithelialisation following systemic administration. We propose that CAR peptide activates SDC4 function to selectively promote re-epithelialisation. Thus, CAR peptide provides an entirely new therapeutic approach to enhance wound healing; systemic, yet target organ- and cell-specific." @default.
- W4224312285 created "2022-04-26" @default.
- W4224312285 creator A5000246031 @default.
- W4224312285 creator A5003868104 @default.
- W4224312285 creator A5006685027 @default.
- W4224312285 creator A5007564280 @default.
- W4224312285 creator A5008653619 @default.
- W4224312285 creator A5013117406 @default.
- W4224312285 creator A5015338148 @default.
- W4224312285 creator A5028542475 @default.
- W4224312285 creator A5041491147 @default.
- W4224312285 creator A5046752513 @default.
- W4224312285 creator A5047861032 @default.
- W4224312285 creator A5058767992 @default.
- W4224312285 creator A5067443922 @default.
- W4224312285 creator A5076378879 @default.
- W4224312285 creator A5088477154 @default.
- W4224312285 date "2022-04-25" @default.
- W4224312285 modified "2023-10-18" @default.
- W4224312285 title "Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function" @default.
- W4224312285 doi "https://doi.org/10.21203/rs.3.rs-1546533/v1" @default.
- W4224312285 hasPublicationYear "2022" @default.
- W4224312285 type Work @default.
- W4224312285 citedByCount "0" @default.
- W4224312285 crossrefType "posted-content" @default.
- W4224312285 hasAuthorship W4224312285A5000246031 @default.
- W4224312285 hasAuthorship W4224312285A5003868104 @default.
- W4224312285 hasAuthorship W4224312285A5006685027 @default.
- W4224312285 hasAuthorship W4224312285A5007564280 @default.
- W4224312285 hasAuthorship W4224312285A5008653619 @default.
- W4224312285 hasAuthorship W4224312285A5013117406 @default.
- W4224312285 hasAuthorship W4224312285A5015338148 @default.
- W4224312285 hasAuthorship W4224312285A5028542475 @default.
- W4224312285 hasAuthorship W4224312285A5041491147 @default.
- W4224312285 hasAuthorship W4224312285A5046752513 @default.
- W4224312285 hasAuthorship W4224312285A5047861032 @default.
- W4224312285 hasAuthorship W4224312285A5058767992 @default.
- W4224312285 hasAuthorship W4224312285A5067443922 @default.
- W4224312285 hasAuthorship W4224312285A5076378879 @default.
- W4224312285 hasAuthorship W4224312285A5088477154 @default.
- W4224312285 hasBestOaLocation W42243122851 @default.
- W4224312285 hasConcept C137738243 @default.
- W4224312285 hasConcept C1491633281 @default.
- W4224312285 hasConcept C151872237 @default.
- W4224312285 hasConcept C185592680 @default.
- W4224312285 hasConcept C18903297 @default.
- W4224312285 hasConcept C203014093 @default.
- W4224312285 hasConcept C2779281246 @default.
- W4224312285 hasConcept C2780269544 @default.
- W4224312285 hasConcept C502942594 @default.
- W4224312285 hasConcept C55493867 @default.
- W4224312285 hasConcept C65001120 @default.
- W4224312285 hasConcept C71924100 @default.
- W4224312285 hasConcept C86803240 @default.
- W4224312285 hasConcept C95444343 @default.
- W4224312285 hasConceptScore W4224312285C137738243 @default.
- W4224312285 hasConceptScore W4224312285C1491633281 @default.
- W4224312285 hasConceptScore W4224312285C151872237 @default.
- W4224312285 hasConceptScore W4224312285C185592680 @default.
- W4224312285 hasConceptScore W4224312285C18903297 @default.
- W4224312285 hasConceptScore W4224312285C203014093 @default.
- W4224312285 hasConceptScore W4224312285C2779281246 @default.
- W4224312285 hasConceptScore W4224312285C2780269544 @default.
- W4224312285 hasConceptScore W4224312285C502942594 @default.
- W4224312285 hasConceptScore W4224312285C55493867 @default.
- W4224312285 hasConceptScore W4224312285C65001120 @default.
- W4224312285 hasConceptScore W4224312285C71924100 @default.
- W4224312285 hasConceptScore W4224312285C86803240 @default.
- W4224312285 hasConceptScore W4224312285C95444343 @default.
- W4224312285 hasLocation W42243122851 @default.
- W4224312285 hasOpenAccess W4224312285 @default.
- W4224312285 hasPrimaryLocation W42243122851 @default.
- W4224312285 hasRelatedWork W10688544 @default.
- W4224312285 hasRelatedWork W16832284 @default.
- W4224312285 hasRelatedWork W19482447 @default.
- W4224312285 hasRelatedWork W19594259 @default.
- W4224312285 hasRelatedWork W21126274 @default.
- W4224312285 hasRelatedWork W28577588 @default.
- W4224312285 hasRelatedWork W5382605 @default.
- W4224312285 hasRelatedWork W5534433 @default.
- W4224312285 hasRelatedWork W5878408 @default.
- W4224312285 hasRelatedWork W605397 @default.
- W4224312285 isParatext "false" @default.
- W4224312285 isRetracted "false" @default.
- W4224312285 workType "article" @default.