FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224313489> ?p ?o ?g. }

• W4224313489 abstract "Photodynamic therapy (PDT) not only destroys tumor cells directly but also induced anti-tumor immune response through damage-associated molecular patterns (DAMPs). It is reported that anti-tumor response was associated with light dose and photosensitizer used in PDT. In this study, 4T1 tumor cells were implanted on both the right and left flanks of mice. Only the right tumor was treated by HpD-PDT, while the left tumor was not irradiated. The anti-tumor immune response induced by HpD-PDT was investigated. The expression of DAMPs and co-stimulatory molecules induced by HpD-PDT were tested by immunofluorescence and flow cytometry in vivo. Different light doses of PDT were designed to treat 4T1 cells. The killing effect was assessed by CCK-8 kit and apoptosis kit. The expression of DAMPs on 4T1 cells after HpD-PDT were evaluated by flow cytometry, western blot and ATP kit. This study showed that CD4[Formula: see text]T, CD8[Formula: see text]T and the production of IFN-[Formula: see text] were increased significantly on day 10 in right-tumor after PDT treatment compared with control group. HpD-PDT enhanced the expression of calreticulin (CRT) on tumor tissue. Importantly, co-stimulatory molecular OX-40 and 4-1BB were elevated on CD8[Formula: see text]T cells. In vitro, immunogenic death of 4T1 cells was induced after PDT. Besides, the expression of DAMPs increased with the increasing of energy density. This study indicates that anti-tumor immune effect was induced by HpD-PDT. The knowledge of the involvement of CRT, ATP and co-stimulatory molecules uncovers important mechanistic insight into the anti-tumor immunogenicity. It was the first time that co-stimulatory molecules were investigated and found to elevate after PDT." @default.
• W4224313489 created "2022-04-26" @default.
• W4224313489 creator A5005001351 @default.
• W4224313489 creator A5021091076 @default.
• W4224313489 creator A5029025387 @default.
• W4224313489 creator A5038625195 @default.
• W4224313489 creator A5043778112 @default.
• W4224313489 creator A5051330675 @default.
• W4224313489 creator A5064829926 @default.
• W4224313489 creator A5065859286 @default.
• W4224313489 creator A5072751960 @default.
• W4224313489 creator A5090802873 @default.
• W4224313489 date "2022-06-04" @default.
• W4224313489 modified "2023-09-27" @default.
• W4224313489 title "Immune response induced by hematoporphyrin derivatives mediated photodynamic therapy: Immunogenic cell death and elevated costimulatory molecules" @default.
• W4224313489 cites W1508756175 @default.
• W4224313489 cites W1530610894 @default.
• W4224313489 cites W1564765245 @default.
• W4224313489 cites W1933888663 @default.
• W4224313489 cites W1942176190 @default.
• W4224313489 cites W1963855786 @default.
• W4224313489 cites W1979007905 @default.
• W4224313489 cites W1994993231 @default.
• W4224313489 cites W2020344052 @default.
• W4224313489 cites W2044268929 @default.
• W4224313489 cites W2047526240 @default.
• W4224313489 cites W2052176070 @default.
• W4224313489 cites W2063717992 @default.
• W4224313489 cites W2066659514 @default.
• W4224313489 cites W2067632426 @default.
• W4224313489 cites W2070695834 @default.
• W4224313489 cites W2071563028 @default.
• W4224313489 cites W2084906892 @default.
• W4224313489 cites W2089966068 @default.
• W4224313489 cites W2112076394 @default.
• W4224313489 cites W2130473166 @default.
• W4224313489 cites W2130789168 @default.
• W4224313489 cites W2139122813 @default.
• W4224313489 cites W2212950451 @default.
• W4224313489 cites W2265004816 @default.
• W4224313489 cites W2292411590 @default.
• W4224313489 cites W2395845086 @default.
• W4224313489 cites W2801255644 @default.
• W4224313489 cites W2995890910 @default.
• W4224313489 cites W3009904823 @default.
• W4224313489 cites W3091714068 @default.
• W4224313489 cites W4205913767 @default.
• W4224313489 cites W4211024586 @default.
• W4224313489 doi "https://doi.org/10.1142/s1793545822400028" @default.
• W4224313489 hasPublicationYear "2022" @default.
• W4224313489 type Work @default.
• W4224313489 citedByCount "2" @default.
• W4224313489 countsByYear W42243134892022 @default.
• W4224313489 countsByYear W42243134892023 @default.
• W4224313489 crossrefType "journal-article" @default.
• W4224313489 hasAuthorship W4224313489A5005001351 @default.
• W4224313489 hasAuthorship W4224313489A5021091076 @default.
• W4224313489 hasAuthorship W4224313489A5029025387 @default.
• W4224313489 hasAuthorship W4224313489A5038625195 @default.
• W4224313489 hasAuthorship W4224313489A5043778112 @default.
• W4224313489 hasAuthorship W4224313489A5051330675 @default.
• W4224313489 hasAuthorship W4224313489A5064829926 @default.
• W4224313489 hasAuthorship W4224313489A5065859286 @default.
• W4224313489 hasAuthorship W4224313489A5072751960 @default.
• W4224313489 hasAuthorship W4224313489A5090802873 @default.
• W4224313489 hasBestOaLocation W42243134891 @default.
• W4224313489 hasConcept C150903083 @default.
• W4224313489 hasConcept C153911025 @default.
• W4224313489 hasConcept C167672396 @default.
• W4224313489 hasConcept C178790620 @default.
• W4224313489 hasConcept C185592680 @default.
• W4224313489 hasConcept C190283241 @default.
• W4224313489 hasConcept C203014093 @default.
• W4224313489 hasConcept C207001950 @default.
• W4224313489 hasConcept C2777701055 @default.
• W4224313489 hasConcept C2777877232 @default.
• W4224313489 hasConcept C2781323092 @default.
• W4224313489 hasConcept C2781469039 @default.
• W4224313489 hasConcept C31573885 @default.
• W4224313489 hasConcept C502942594 @default.
• W4224313489 hasConcept C553184892 @default.
• W4224313489 hasConcept C55493867 @default.
• W4224313489 hasConcept C86803240 @default.
• W4224313489 hasConcept C8891405 @default.
• W4224313489 hasConceptScore W4224313489C150903083 @default.
• W4224313489 hasConceptScore W4224313489C153911025 @default.
• W4224313489 hasConceptScore W4224313489C167672396 @default.
• W4224313489 hasConceptScore W4224313489C178790620 @default.
• W4224313489 hasConceptScore W4224313489C185592680 @default.
• W4224313489 hasConceptScore W4224313489C190283241 @default.
• W4224313489 hasConceptScore W4224313489C203014093 @default.
• W4224313489 hasConceptScore W4224313489C207001950 @default.
• W4224313489 hasConceptScore W4224313489C2777701055 @default.
• W4224313489 hasConceptScore W4224313489C2777877232 @default.
• W4224313489 hasConceptScore W4224313489C2781323092 @default.
• W4224313489 hasConceptScore W4224313489C2781469039 @default.
• W4224313489 hasConceptScore W4224313489C31573885 @default.
• W4224313489 hasConceptScore W4224313489C502942594 @default.
• W4224313489 hasConceptScore W4224313489C553184892 @default.
• W4224313489 hasConceptScore W4224313489C55493867 @default.

• next