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- W4224319916 endingPage "871" @default.
- W4224319916 startingPage "871" @default.
- W4224319916 abstract "Circular RNAs (circRNAs) are single-stranded RNAs with a covalently closed-loop structure that increases their stability; thus, they are more advantageous to use as liquid biopsy markers than linear RNAs. circRNAs are thought to be generated by back-splicing of pre-mRNA transcripts, which can be facilitated by reverse complementary sequences in the flanking introns and trans-acting factors, such as splicing regulatory factors and RNA-binding factors. circRNAs function as miRNA sponges, interact with target proteins, regulate the stability and translatability of other mRNAs, regulate gene expression, and produce microproteins. circRNAs are also found in the body fluids of cancer patients, including plasma, saliva, urine, and cerebrospinal fluid, and these “circulating circRNAs” can be used as cancer biomarkers. In lung cancer, some circulating circRNAs have been reported to regulate cancer progression and drug resistance. Circulating circRNAs have significant diagnostic value and are associated with the prognosis of lung cancer patients. Owing to their functional versatility, heightened stability, and practical applicability, circulating circRNAs represent promising biomarkers for lung cancer diagnosis, prognosis, and treatment monitoring." @default.
- W4224319916 created "2022-04-26" @default.
- W4224319916 creator A5003463853 @default.
- W4224319916 creator A5021284321 @default.
- W4224319916 creator A5032106207 @default.
- W4224319916 creator A5078614827 @default.
- W4224319916 date "2022-04-08" @default.
- W4224319916 modified "2023-10-15" @default.
- W4224319916 title "Clinical Implications of Circulating Circular RNAs in Lung Cancer" @default.
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- W4224319916 doi "https://doi.org/10.3390/biomedicines10040871" @default.
- W4224319916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35453621" @default.
- W4224319916 hasPublicationYear "2022" @default.