Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224324596> ?p ?o ?g. }
- W4224324596 endingPage "2722" @default.
- W4224324596 startingPage "2722" @default.
- W4224324596 abstract "The efficient regioselective bromination and iodination of the nonsteroidal anti-inflammatory drug (NSAID) carprofen were achieved by using bromine and iodine monochloride in glacial acetic acid. The novel halogenated carprofen derivatives were functionalized at the carboxylic group by esterification. The regioselectivity of the halogenation reaction was evidenced by NMR spectroscopy and confirmed by X-ray analysis. The compounds were screened for their in vitro antibacterial activity against planktonic cells and also for their anti-biofilm effect, using Gram-positive bacteria (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212) and Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The cytotoxic activity of the novel compounds was tested against HeLa cells. The pharmacokinetic and pharmacodynamic profiles of carprofen derivatives, as well as their toxicity, were established by in silico analyses." @default.
- W4224324596 created "2022-04-26" @default.
- W4224324596 creator A5001059217 @default.
- W4224324596 creator A5010002183 @default.
- W4224324596 creator A5037454823 @default.
- W4224324596 creator A5038378457 @default.
- W4224324596 creator A5038960448 @default.
- W4224324596 creator A5046184530 @default.
- W4224324596 creator A5050112685 @default.
- W4224324596 creator A5058777606 @default.
- W4224324596 creator A5082550113 @default.
- W4224324596 creator A5089257773 @default.
- W4224324596 creator A5089539938 @default.
- W4224324596 date "2022-04-23" @default.
- W4224324596 modified "2023-10-18" @default.
- W4224324596 title "In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives" @default.
- W4224324596 cites W105152574 @default.
- W4224324596 cites W2009770943 @default.
- W4224324596 cites W2009867031 @default.
- W4224324596 cites W2016745529 @default.
- W4224324596 cites W2046949121 @default.
- W4224324596 cites W2067740761 @default.
- W4224324596 cites W2071136554 @default.
- W4224324596 cites W2093341428 @default.
- W4224324596 cites W2103914416 @default.
- W4224324596 cites W2114471642 @default.
- W4224324596 cites W2121074897 @default.
- W4224324596 cites W2144440398 @default.
- W4224324596 cites W2147558970 @default.
- W4224324596 cites W2462202954 @default.
- W4224324596 cites W2578865974 @default.
- W4224324596 cites W2804369996 @default.
- W4224324596 cites W2805451664 @default.
- W4224324596 cites W2890270964 @default.
- W4224324596 cites W2890840933 @default.
- W4224324596 cites W2891862044 @default.
- W4224324596 cites W2964458079 @default.
- W4224324596 cites W2973965923 @default.
- W4224324596 cites W2980569254 @default.
- W4224324596 cites W2999096321 @default.
- W4224324596 cites W3000118940 @default.
- W4224324596 cites W3000720869 @default.
- W4224324596 cites W3019688672 @default.
- W4224324596 cites W3028648654 @default.
- W4224324596 cites W3029917582 @default.
- W4224324596 cites W3036254284 @default.
- W4224324596 cites W3042705749 @default.
- W4224324596 cites W3047536595 @default.
- W4224324596 cites W3048569212 @default.
- W4224324596 cites W3094522698 @default.
- W4224324596 cites W3111176295 @default.
- W4224324596 cites W3111642878 @default.
- W4224324596 cites W3130768715 @default.
- W4224324596 cites W3155899399 @default.
- W4224324596 cites W3174061112 @default.
- W4224324596 cites W3182134241 @default.
- W4224324596 cites W3185083450 @default.
- W4224324596 doi "https://doi.org/10.3390/molecules27092722" @default.
- W4224324596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35566083" @default.
- W4224324596 hasPublicationYear "2022" @default.
- W4224324596 type Work @default.
- W4224324596 citedByCount "3" @default.
- W4224324596 countsByYear W42243245962023 @default.
- W4224324596 crossrefType "journal-article" @default.
- W4224324596 hasAuthorship W4224324596A5001059217 @default.
- W4224324596 hasAuthorship W4224324596A5010002183 @default.
- W4224324596 hasAuthorship W4224324596A5037454823 @default.
- W4224324596 hasAuthorship W4224324596A5038378457 @default.
- W4224324596 hasAuthorship W4224324596A5038960448 @default.
- W4224324596 hasAuthorship W4224324596A5046184530 @default.
- W4224324596 hasAuthorship W4224324596A5050112685 @default.
- W4224324596 hasAuthorship W4224324596A5058777606 @default.
- W4224324596 hasAuthorship W4224324596A5082550113 @default.
- W4224324596 hasAuthorship W4224324596A5089257773 @default.
- W4224324596 hasAuthorship W4224324596A5089539938 @default.
- W4224324596 hasBestOaLocation W42243245961 @default.
- W4224324596 hasConcept C104317684 @default.
- W4224324596 hasConcept C178790620 @default.
- W4224324596 hasConcept C185592680 @default.
- W4224324596 hasConcept C202751555 @default.
- W4224324596 hasConcept C21951064 @default.
- W4224324596 hasConcept C2777366897 @default.
- W4224324596 hasConcept C2777637488 @default.
- W4224324596 hasConcept C2779895986 @default.
- W4224324596 hasConcept C2780741920 @default.
- W4224324596 hasConcept C523546767 @default.
- W4224324596 hasConcept C54355233 @default.
- W4224324596 hasConcept C547475151 @default.
- W4224324596 hasConcept C55493867 @default.
- W4224324596 hasConcept C65973085 @default.
- W4224324596 hasConcept C71240020 @default.
- W4224324596 hasConcept C86803240 @default.
- W4224324596 hasConceptScore W4224324596C104317684 @default.
- W4224324596 hasConceptScore W4224324596C178790620 @default.
- W4224324596 hasConceptScore W4224324596C185592680 @default.
- W4224324596 hasConceptScore W4224324596C202751555 @default.
- W4224324596 hasConceptScore W4224324596C21951064 @default.
- W4224324596 hasConceptScore W4224324596C2777366897 @default.