Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224435094> ?p ?o ?g. }
- W4224435094 abstract "Interferon regulatory factors ( IRF s) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRF s play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRF s. In the present study, four IRF family genes ( CfIRF1, CfIRF1-like, CfIRF2 , and CfIRF8 ) were identified from Zhikong scallop ( Chlamys farreri ) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like , and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on Cf IRF1, Cf IRF1-like, and Cf IRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like , CfIRF2 showed the most sensitive responses in coping with V. anguillarum , and consistently, Cf IRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs." @default.
- W4224435094 created "2022-04-27" @default.
- W4224435094 creator A5009110720 @default.
- W4224435094 creator A5023174626 @default.
- W4224435094 creator A5025212041 @default.
- W4224435094 creator A5033807860 @default.
- W4224435094 creator A5040584913 @default.
- W4224435094 creator A5041880317 @default.
- W4224435094 creator A5059736823 @default.
- W4224435094 creator A5064639776 @default.
- W4224435094 creator A5064683226 @default.
- W4224435094 date "2022-04-26" @default.
- W4224435094 modified "2023-10-01" @default.
- W4224435094 title "Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri" @default.
- W4224435094 cites W1786654010 @default.
- W4224435094 cites W1963588416 @default.
- W4224435094 cites W1971076179 @default.
- W4224435094 cites W1973701834 @default.
- W4224435094 cites W1978090289 @default.
- W4224435094 cites W1978990512 @default.
- W4224435094 cites W1980855342 @default.
- W4224435094 cites W1987015602 @default.
- W4224435094 cites W1987799551 @default.
- W4224435094 cites W1992293963 @default.
- W4224435094 cites W2005452204 @default.
- W4224435094 cites W2005884645 @default.
- W4224435094 cites W2010609657 @default.
- W4224435094 cites W2011330612 @default.
- W4224435094 cites W2014890686 @default.
- W4224435094 cites W2021951044 @default.
- W4224435094 cites W2026432913 @default.
- W4224435094 cites W2028642680 @default.
- W4224435094 cites W2031904443 @default.
- W4224435094 cites W2033819389 @default.
- W4224435094 cites W2037993016 @default.
- W4224435094 cites W2038569455 @default.
- W4224435094 cites W2047435595 @default.
- W4224435094 cites W2048644094 @default.
- W4224435094 cites W2050430270 @default.
- W4224435094 cites W2054132042 @default.
- W4224435094 cites W2056970059 @default.
- W4224435094 cites W2063082801 @default.
- W4224435094 cites W2064641233 @default.
- W4224435094 cites W2066680385 @default.
- W4224435094 cites W2067597532 @default.
- W4224435094 cites W2073337913 @default.
- W4224435094 cites W2074757850 @default.
- W4224435094 cites W2077206825 @default.
- W4224435094 cites W2077291760 @default.
- W4224435094 cites W2087878020 @default.
- W4224435094 cites W2099249565 @default.
- W4224435094 cites W2099457187 @default.
- W4224435094 cites W2111048324 @default.
- W4224435094 cites W2121782927 @default.
- W4224435094 cites W2135279653 @default.
- W4224435094 cites W2145405923 @default.
- W4224435094 cites W2147640266 @default.
- W4224435094 cites W2163853656 @default.
- W4224435094 cites W2167065653 @default.
- W4224435094 cites W2170654373 @default.
- W4224435094 cites W233148420 @default.
- W4224435094 cites W2334859192 @default.
- W4224435094 cites W2394984326 @default.
- W4224435094 cites W2523697340 @default.
- W4224435094 cites W2742768529 @default.
- W4224435094 cites W2769613350 @default.
- W4224435094 cites W2793309047 @default.
- W4224435094 cites W2799524357 @default.
- W4224435094 cites W2855942143 @default.
- W4224435094 cites W2885863301 @default.
- W4224435094 cites W2924224681 @default.
- W4224435094 cites W3015566521 @default.
- W4224435094 cites W3019690273 @default.
- W4224435094 cites W3090956370 @default.
- W4224435094 cites W3107571512 @default.
- W4224435094 doi "https://doi.org/10.3389/fmars.2022.865707" @default.
- W4224435094 hasPublicationYear "2022" @default.
- W4224435094 type Work @default.
- W4224435094 citedByCount "2" @default.
- W4224435094 countsByYear W42244350942023 @default.
- W4224435094 crossrefType "journal-article" @default.
- W4224435094 hasAuthorship W4224435094A5009110720 @default.
- W4224435094 hasAuthorship W4224435094A5023174626 @default.
- W4224435094 hasAuthorship W4224435094A5025212041 @default.
- W4224435094 hasAuthorship W4224435094A5033807860 @default.
- W4224435094 hasAuthorship W4224435094A5040584913 @default.
- W4224435094 hasAuthorship W4224435094A5041880317 @default.
- W4224435094 hasAuthorship W4224435094A5059736823 @default.
- W4224435094 hasAuthorship W4224435094A5064639776 @default.
- W4224435094 hasAuthorship W4224435094A5064683226 @default.
- W4224435094 hasBestOaLocation W42244350941 @default.
- W4224435094 hasConcept C100068826 @default.
- W4224435094 hasConcept C101762097 @default.
- W4224435094 hasConcept C104317684 @default.
- W4224435094 hasConcept C136449434 @default.
- W4224435094 hasConcept C150194340 @default.
- W4224435094 hasConcept C2776154503 @default.
- W4224435094 hasConcept C2776178377 @default.
- W4224435094 hasConcept C2781348184 @default.
- W4224435094 hasConcept C32300475 @default.