FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224439910> ?p ?o ?g. }

• W4224439910 endingPage "189" @default.
• W4224439910 startingPage "176" @default.
• W4224439910 abstract "Genetic screens are used in Drosophila melanogaster to identify genes key in the regulation of organismal development and growth. These screens have defined signalling pathways necessary for tissue and organismal development, which are evolutionarily conserved across species, including Drosophila. Here, we have used an FLP/FRT mosaic system to screen for conditional regulators of cell growth and cell division in the Drosophila eye. The conditional nature of this screen utilizes a block in the apoptotic pathway to prohibit the mosaic mutant cells from dying via apoptosis. From this screen, we identified two different mutants that mapped to the Hedgehog signalling pathway. Previously, we described a novel Ptc mutation and here we add to the understanding of disrupting the Hh pathway with a novel allele of Cos2. Both of these Hh components are negative regulators of the pathway, yet they depict mutant differences in the type of overgrowth created. Ptc mutations lead to overgrowth consisting of almost entirely wild-type tissue (non-autonomous overgrowth), while the Cos2 mutation results in tissue that is overgrown in both the mutant and wild-type clones (both autonomous and non-autonomous). These differences in tissue overgrowth are consistent in the Drosophila eye and wing. The observed difference is correlated with different deregulation patterns of pMad, the downstream effector of DPP signalling. This finding provides insight into pathway-specific differences that help to better understand intricacies of developmental processes and human diseases that result from deregulated Hedgehog signalling, such as basal cell carcinoma." @default.
• W4224439910 created "2022-04-27" @default.
• W4224439910 creator A5000225988 @default.
• W4224439910 creator A5000257708 @default.
• W4224439910 creator A5013081760 @default.
• W4224439910 creator A5021579483 @default.
• W4224439910 creator A5021769329 @default.
• W4224439910 creator A5025931950 @default.
• W4224439910 creator A5045456924 @default.
• W4224439910 creator A5073250263 @default.
• W4224439910 creator A5083382968 @default.
• W4224439910 date "2022-04-25" @default.
• W4224439910 modified "2023-10-01" @default.
• W4224439910 title "<i>Patched</i> and <i>Costal-2</i> mutations lead to differences in tissue overgrowth autonomy" @default.
• W4224439910 cites W1968717680 @default.
• W4224439910 cites W1971605415 @default.
• W4224439910 cites W1972914406 @default.
• W4224439910 cites W1982124131 @default.
• W4224439910 cites W1989382065 @default.
• W4224439910 cites W1992418538 @default.
• W4224439910 cites W2000572318 @default.
• W4224439910 cites W2009455581 @default.
• W4224439910 cites W2012674191 @default.
• W4224439910 cites W2014545259 @default.
• W4224439910 cites W2027125425 @default.
• W4224439910 cites W2034269086 @default.
• W4224439910 cites W2037365320 @default.
• W4224439910 cites W2037666638 @default.
• W4224439910 cites W2038256548 @default.
• W4224439910 cites W2040930127 @default.
• W4224439910 cites W2045188553 @default.
• W4224439910 cites W2045947221 @default.
• W4224439910 cites W2052521454 @default.
• W4224439910 cites W2063692873 @default.
• W4224439910 cites W2073568903 @default.
• W4224439910 cites W2077457288 @default.
• W4224439910 cites W2083106714 @default.
• W4224439910 cites W2094809543 @default.
• W4224439910 cites W2098176608 @default.
• W4224439910 cites W2118066400 @default.
• W4224439910 cites W2127001212 @default.
• W4224439910 cites W2142227317 @default.
• W4224439910 cites W2142478633 @default.
• W4224439910 cites W2146959145 @default.
• W4224439910 cites W2160889747 @default.
• W4224439910 cites W2164101293 @default.
• W4224439910 cites W2168125601 @default.
• W4224439910 cites W2170048206 @default.
• W4224439910 cites W2526156281 @default.
• W4224439910 cites W2777635693 @default.
• W4224439910 cites W2956107512 @default.
• W4224439910 cites W2981924266 @default.
• W4224439910 doi "https://doi.org/10.1080/19336934.2022.2062991" @default.
• W4224439910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35468034" @default.
• W4224439910 hasPublicationYear "2022" @default.
• W4224439910 type Work @default.
• W4224439910 citedByCount "2" @default.
• W4224439910 countsByYear W42244399102023 @default.
• W4224439910 crossrefType "journal-article" @default.
• W4224439910 hasAuthorship W4224439910A5000225988 @default.
• W4224439910 hasAuthorship W4224439910A5000257708 @default.
• W4224439910 hasAuthorship W4224439910A5013081760 @default.
• W4224439910 hasAuthorship W4224439910A5021579483 @default.
• W4224439910 hasAuthorship W4224439910A5021769329 @default.
• W4224439910 hasAuthorship W4224439910A5025931950 @default.
• W4224439910 hasAuthorship W4224439910A5045456924 @default.
• W4224439910 hasAuthorship W4224439910A5073250263 @default.
• W4224439910 hasAuthorship W4224439910A5083382968 @default.
• W4224439910 hasBestOaLocation W42244399101 @default.
• W4224439910 hasConcept C104317684 @default.
• W4224439910 hasConcept C143065580 @default.
• W4224439910 hasConcept C207177822 @default.
• W4224439910 hasConcept C2778539099 @default.
• W4224439910 hasConcept C2780104201 @default.
• W4224439910 hasConcept C501734568 @default.
• W4224439910 hasConcept C51785407 @default.
• W4224439910 hasConcept C54355233 @default.
• W4224439910 hasConcept C62478195 @default.
• W4224439910 hasConcept C86803240 @default.
• W4224439910 hasConcept C88498014 @default.
• W4224439910 hasConcept C95444343 @default.
• W4224439910 hasConceptScore W4224439910C104317684 @default.
• W4224439910 hasConceptScore W4224439910C143065580 @default.
• W4224439910 hasConceptScore W4224439910C207177822 @default.
• W4224439910 hasConceptScore W4224439910C2778539099 @default.
• W4224439910 hasConceptScore W4224439910C2780104201 @default.
• W4224439910 hasConceptScore W4224439910C501734568 @default.
• W4224439910 hasConceptScore W4224439910C51785407 @default.
• W4224439910 hasConceptScore W4224439910C54355233 @default.
• W4224439910 hasConceptScore W4224439910C62478195 @default.
• W4224439910 hasConceptScore W4224439910C86803240 @default.
• W4224439910 hasConceptScore W4224439910C88498014 @default.
• W4224439910 hasConceptScore W4224439910C95444343 @default.
• W4224439910 hasFunder F4320332161 @default.
• W4224439910 hasFunder F4320337354 @default.
• W4224439910 hasIssue "1" @default.
• W4224439910 hasLocation W42244399101 @default.
• W4224439910 hasLocation W42244399102 @default.

• next