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- W4224440205 abstract "Exercise-based cardiac rehabilitation may be an effective non-pharmacological intervention for improving endothelial function in coronary artery disease patients. Therefore, this systematic review with meta-analysis aimed to (a) estimate the training-induced effect on endothelial and vascular smooth muscle function, assessed by flow-mediated dilation and nitroglycerin-mediated dilation, respectively, in coronary artery disease patients; and to (b) study the influence of potential trial-level variables (i. e. study and intervention characteristics) on the training-induced effect on endothelial and vascular smooth muscle function. Electronic searches were performed in Pubmed, Scopus, and Embase up to February 2021. Random-effects models of standardised mean change were estimated. Heterogeneity analyses were performed by using the Chi2 test and I2 index. Our results showed that exercise-based cardiac rehabilitation significantly enhanced flow-mediated dilation (1.04 [95% confidence interval=0.76 to 1.31]) but did not significantly change nitroglycerin-mediated dilation (0.05 [95% confidence interval=-0.03 to 0.13]). Heterogeneity testing reached statistical significance (p<.001) with high inconsistency for flow-mediated dilation (I2=92%). Nevertheless, none of the analysed variables influenced the training-induced effect on flow-mediated dilation. Exercise-based cardiac rehabilitation seems to be an effective therapeutic strategy for improving endothelial-dependent dilation in coronary artery disease patients, which may aid in the prevention of cardiovascular events." @default.
- W4224440205 created "2022-04-27" @default.
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- W4224440205 creator A5089744689 @default.
- W4224440205 date "2022-04-25" @default.
- W4224440205 modified "2023-09-26" @default.
- W4224440205 title "Cardiac Rehabilitation Improves Endothelial Function in Coronary Artery Disease Patients" @default.
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- W4224440205 doi "https://doi.org/10.1055/a-1717-1798" @default.
- W4224440205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35468652" @default.
- W4224440205 hasPublicationYear "2022" @default.
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