FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224441392> ?p ?o ?g. }

• W4224441392 endingPage "147927" @default.
• W4224441392 startingPage "147927" @default.
• W4224441392 abstract "Spinal mechanisms associated with visceral hypersensitivity are poorly understood. One model of bladder hypersensitivity with phenotypic features similar to the disorder interstitial cystitis/bladder pain syndrome is the neonatal bladder inflammation (NBI) model. In this model, rat pup bladders are infused with zymosan solutions on post-partum days 14–16 and then rats are retested as adults. Studies of other sites of deep tissue hypersensitivity have suggested a role for corticotropin-releasing factor (CRF) receptors type 1 and 2 (CRFR1 and CRFR2). Using neurochemical measures, pharmacological manipulations and both reflex and neuronal responses to urinary bladder distension as endpoints, the present study probed the role of CRFR2s in bladder hyperalgesia secondary to NBI and acute bladder re-inflammation as an adult (ABI). ELISA measures of the lumbosacral spinal cord demonstrated increased CRFR1s and CRFR2s following pretreatment with both NBI + ABI as well as NBI-related increases in the CRFR2 agonist urocortin 2. Intrathecal CRFR2 antagonists, but not a CRFR1 antagonist, blocked the augmentation of visceromotor responses to distension following pretreatment with both NBI + ABI. Lumbosacral dorsal horn neuronal responses to distension in rats pretreated with NBI + ABI were attenuated by the spinal topical administration of a CRFR2 antagonist. These studies suggest therapeutic value of CRFR2 antagonists in the treatment of painful bladder disorders." @default.
• W4224441392 created "2022-04-27" @default.
• W4224441392 creator A5024942419 @default.
• W4224441392 creator A5069114209 @default.
• W4224441392 creator A5069317108 @default.
• W4224441392 date "2022-08-01" @default.
• W4224441392 modified "2023-10-13" @default.
• W4224441392 title "Neonatal cystitis leads to alterations in spinal corticotropin releasing factor receptor-type 2 content and function in adult rats following bladder re-inflammation" @default.
• W4224441392 cites W108337335 @default.
• W4224441392 cites W1485511015 @default.
• W4224441392 cites W1919014346 @default.
• W4224441392 cites W1955175219 @default.
• W4224441392 cites W1968182280 @default.
• W4224441392 cites W1968858550 @default.
• W4224441392 cites W1970050155 @default.
• W4224441392 cites W1971232069 @default.
• W4224441392 cites W1973423895 @default.
• W4224441392 cites W1997193773 @default.
• W4224441392 cites W2002707455 @default.
• W4224441392 cites W2005062124 @default.
• W4224441392 cites W2015287365 @default.
• W4224441392 cites W2017492295 @default.
• W4224441392 cites W2019208784 @default.
• W4224441392 cites W2022138356 @default.
• W4224441392 cites W2039758747 @default.
• W4224441392 cites W2040855021 @default.
• W4224441392 cites W2046281206 @default.
• W4224441392 cites W2046779945 @default.
• W4224441392 cites W2048129629 @default.
• W4224441392 cites W2058685218 @default.
• W4224441392 cites W2076337848 @default.
• W4224441392 cites W2077466839 @default.
• W4224441392 cites W2080935944 @default.
• W4224441392 cites W2081116551 @default.
• W4224441392 cites W2083608576 @default.
• W4224441392 cites W2087454739 @default.
• W4224441392 cites W2090781926 @default.
• W4224441392 cites W2095646540 @default.
• W4224441392 cites W2099987899 @default.
• W4224441392 cites W2100941807 @default.
• W4224441392 cites W2102414953 @default.
• W4224441392 cites W2107104822 @default.
• W4224441392 cites W2119980381 @default.
• W4224441392 cites W2130765180 @default.
• W4224441392 cites W2131074115 @default.
• W4224441392 cites W2133116107 @default.
• W4224441392 cites W2138386847 @default.
• W4224441392 cites W2140141526 @default.
• W4224441392 cites W2158080912 @default.
• W4224441392 cites W2158824619 @default.
• W4224441392 cites W2165284393 @default.
• W4224441392 cites W2465899112 @default.
• W4224441392 cites W2536422041 @default.
• W4224441392 cites W2582976680 @default.
• W4224441392 cites W2593254042 @default.
• W4224441392 cites W2594351553 @default.
• W4224441392 cites W2734081746 @default.
• W4224441392 cites W2752882326 @default.
• W4224441392 cites W2892370605 @default.
• W4224441392 cites W2975918830 @default.
• W4224441392 cites W3027642407 @default.
• W4224441392 cites W4200505098 @default.
• W4224441392 cites W4200570065 @default.
• W4224441392 cites W4206673203 @default.
• W4224441392 doi "https://doi.org/10.1016/j.brainres.2022.147927" @default.
• W4224441392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35477003" @default.
• W4224441392 hasPublicationYear "2022" @default.
• W4224441392 type Work @default.
• W4224441392 citedByCount "2" @default.
• W4224441392 countsByYear W42244413922022 @default.
• W4224441392 countsByYear W42244413922023 @default.
• W4224441392 crossrefType "journal-article" @default.
• W4224441392 hasAuthorship W4224441392A5024942419 @default.
• W4224441392 hasAuthorship W4224441392A5069114209 @default.
• W4224441392 hasAuthorship W4224441392A5069317108 @default.
• W4224441392 hasBestOaLocation W42244413921 @default.
• W4224441392 hasConcept C118552586 @default.
• W4224441392 hasConcept C126322002 @default.
• W4224441392 hasConcept C134018914 @default.
• W4224441392 hasConcept C141071460 @default.
• W4224441392 hasConcept C15490471 @default.
• W4224441392 hasConcept C170493617 @default.
• W4224441392 hasConcept C2776625112 @default.
• W4224441392 hasConcept C2776914184 @default.
• W4224441392 hasConcept C2778508898 @default.
• W4224441392 hasConcept C2779245659 @default.
• W4224441392 hasConcept C2779762690 @default.
• W4224441392 hasConcept C2779794527 @default.
• W4224441392 hasConcept C2780775167 @default.
• W4224441392 hasConcept C42219234 @default.
• W4224441392 hasConcept C7146039 @default.
• W4224441392 hasConcept C71924100 @default.
• W4224441392 hasConcept C77411442 @default.
• W4224441392 hasConceptScore W4224441392C118552586 @default.
• W4224441392 hasConceptScore W4224441392C126322002 @default.
• W4224441392 hasConceptScore W4224441392C134018914 @default.
• W4224441392 hasConceptScore W4224441392C141071460 @default.
• W4224441392 hasConceptScore W4224441392C15490471 @default.

• next