FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224442159> ?p ?o ?g. }

• W4224442159 abstract "Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects both cartilage and the underlying subchondral bone. However, spatial relationships between cartilage lesion severity (CLS) and microstructural changes in subchondral plate and trabecular bone remain elusive. Herein, we collected femoral heads from hip arthroplasty for primary osteoarthritis (n = 7) and femoral neck fracture (n = 6; non-OA controls) cases. Samples were regionally assessed for cartilage lesions by visual inspection using Outerbridge classification and entire femoral heads were micro-CT scanned. Scans of each femoral head were divided into 4 quadrants followed by morphometric analysis of subchondral plate and trabecular bone in each quadrant. Principal component analysis (PCA), a data reduction method, was employed to assess differences between OA and non-OA samples, and spatial relationship between CLS and subchondral bone changes. Mapping of the trabecular bone microstructure in OA patients with low CLS revealed trabecular organisation resembling non-OA patients, whereas clear differences were identifiable in subchondral plate architecture. The OA-related changes in subchondral plate architecture were summarised in the first principle component (PC1) which correlated with CLS in all quadrants, whilst by comparison such associations in trabecular bone were most prominent in the higher weight-bearing regions of the femoral head. Greater articular cartilage deterioration in OA was regionally-linked with lower BV/TV, TMD and thickness, and greater BS/BV and porosity in the subchondral plate; and with thinner, less separated trabeculae with greater TMD and BS/BV in the trabecular bone. Our findings suggest that impairment of subchondral bone microstructure in early stage of OA is more readily discernible in the cortical plate and that morphological characterisation of the femoral head bone microstructure may allow for earlier OA diagnosis and monitoring of progression." @default.
• W4224442159 created "2022-04-27" @default.
• W4224442159 creator A5013237227 @default.
• W4224442159 creator A5017484753 @default.
• W4224442159 creator A5017849527 @default.
• W4224442159 creator A5020057358 @default.
• W4224442159 creator A5028095438 @default.
• W4224442159 creator A5036353612 @default.
• W4224442159 creator A5050593017 @default.
• W4224442159 creator A5073315164 @default.
• W4224442159 date "2022-04-23" @default.
• W4224442159 modified "2023-10-10" @default.
• W4224442159 title "Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints" @default.
• W4224442159 cites W1967170359 @default.
• W4224442159 cites W1984367241 @default.
• W4224442159 cites W1986174601 @default.
• W4224442159 cites W2004806078 @default.
• W4224442159 cites W2005692528 @default.
• W4224442159 cites W2013462509 @default.
• W4224442159 cites W2025081386 @default.
• W4224442159 cites W2031317364 @default.
• W4224442159 cites W2032160444 @default.
• W4224442159 cites W2039319793 @default.
• W4224442159 cites W2042941548 @default.
• W4224442159 cites W2043834774 @default.
• W4224442159 cites W2047956062 @default.
• W4224442159 cites W2048621567 @default.
• W4224442159 cites W2051698057 @default.
• W4224442159 cites W2055377091 @default.
• W4224442159 cites W2059317413 @default.
• W4224442159 cites W2064513067 @default.
• W4224442159 cites W2083847239 @default.
• W4224442159 cites W2093001636 @default.
• W4224442159 cites W2100856491 @default.
• W4224442159 cites W2104899682 @default.
• W4224442159 cites W2105342812 @default.
• W4224442159 cites W2106020268 @default.
• W4224442159 cites W2107101733 @default.
• W4224442159 cites W2112779928 @default.
• W4224442159 cites W2115435552 @default.
• W4224442159 cites W2119133264 @default.
• W4224442159 cites W2133915381 @default.
• W4224442159 cites W2153914056 @default.
• W4224442159 cites W2162524321 @default.
• W4224442159 cites W2165073997 @default.
• W4224442159 cites W2166592703 @default.
• W4224442159 cites W2170341226 @default.
• W4224442159 cites W2324531670 @default.
• W4224442159 cites W2417041586 @default.
• W4224442159 cites W2575028522 @default.
• W4224442159 cites W2769342282 @default.
• W4224442159 cites W2833100136 @default.
• W4224442159 cites W3013187652 @default.
• W4224442159 cites W3048503165 @default.
• W4224442159 cites W3177088036 @default.
• W4224442159 cites W4210254819 @default.
• W4224442159 cites W4211058184 @default.
• W4224442159 cites W4211069396 @default.
• W4224442159 cites W4245644463 @default.
• W4224442159 cites W653895738 @default.
• W4224442159 doi "https://doi.org/10.1038/s41598-022-10600-6" @default.
• W4224442159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35461315" @default.
• W4224442159 hasPublicationYear "2022" @default.
• W4224442159 type Work @default.
• W4224442159 citedByCount "6" @default.
• W4224442159 countsByYear W42244421592022 @default.
• W4224442159 countsByYear W42244421592023 @default.
• W4224442159 crossrefType "journal-article" @default.
• W4224442159 hasAuthorship W4224442159A5013237227 @default.
• W4224442159 hasAuthorship W4224442159A5017484753 @default.
• W4224442159 hasAuthorship W4224442159A5017849527 @default.
• W4224442159 hasAuthorship W4224442159A5020057358 @default.
• W4224442159 hasAuthorship W4224442159A5028095438 @default.
• W4224442159 hasAuthorship W4224442159A5036353612 @default.
• W4224442159 hasAuthorship W4224442159A5050593017 @default.
• W4224442159 hasAuthorship W4224442159A5073315164 @default.
• W4224442159 hasBestOaLocation W42244421591 @default.
• W4224442159 hasConcept C105702510 @default.
• W4224442159 hasConcept C142724271 @default.
• W4224442159 hasConcept C204787440 @default.
• W4224442159 hasConcept C2775854910 @default.
• W4224442159 hasConcept C2776164576 @default.
• W4224442159 hasConcept C2776541429 @default.
• W4224442159 hasConcept C2779100257 @default.
• W4224442159 hasConcept C2780550940 @default.
• W4224442159 hasConcept C2780639617 @default.
• W4224442159 hasConcept C2781156865 @default.
• W4224442159 hasConcept C3018615303 @default.
• W4224442159 hasConcept C3020332539 @default.
• W4224442159 hasConcept C71924100 @default.
• W4224442159 hasConceptScore W4224442159C105702510 @default.
• W4224442159 hasConceptScore W4224442159C142724271 @default.
• W4224442159 hasConceptScore W4224442159C204787440 @default.
• W4224442159 hasConceptScore W4224442159C2775854910 @default.
• W4224442159 hasConceptScore W4224442159C2776164576 @default.
• W4224442159 hasConceptScore W4224442159C2776541429 @default.
• W4224442159 hasConceptScore W4224442159C2779100257 @default.
• W4224442159 hasConceptScore W4224442159C2780550940 @default.
• W4224442159 hasConceptScore W4224442159C2780639617 @default.
• W4224442159 hasConceptScore W4224442159C2781156865 @default.

• next