FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224443432> ?p ?o ?g. }

• W4224443432 abstract "Smoke exposure culminates as a progressive lung complication involving airway inflammation and remodeling. While primary smoke poses the greatest risk, nearly half of the US population is also at risk due to exposure to secondhand smoke (SHS).We used WT, RAGE-/- (KO), and Tet-inducible lung-specific RAGE overexpressing transgenic (TG) mice to study the role of RAGE during short-term responses to SHS. We evaluated SHS effects in mice with and without semi-synthetic glycosaminoglycan ethers (SAGEs), which are anionic, partially lipophilic sulfated polysaccharide derivatives known to inhibit RAGE signaling. TG Mice were weaned and fed doxycycline to induce RAGE at postnatal day (PN) 30. At PN40, mice from each line were exposed to room air (RA) or SHS from three Kentucky 3R4F research cigarettes via a nose-only delivery system (Scireq Scientific, Montreal, Canada) five days a week and i.p. injections of PBS or SAGE (30 mg/kg body weight) occurred three times per week from PN40-70 before mice were sacrificed on PN70.RAGE mRNA and protein expression was elevated following SHS exposure of control and TG mice and not detected in RAGE KO mice. Bronchoalveolar lavage fluid (BALF) analysis revealed RAGE-mediated influence on inflammatory cell diapedesis, total protein, and pro-inflammatory mediators following exposure. Lung histological assessment revealed indistinguishable morphology following exposure, yet parenchymal apoptosis was increased. Inflammatory signaling intermediates such as Ras and NF-κB, as well as downstream responses were influenced by the availability of RAGE, as evidenced by RAGE KO and SAGE treatment.These data provide fascinating insight suggesting therapeutic potential for the use of RAGE inhibitors in lungs exposed to SHS smoke." @default.
• W4224443432 created "2022-04-27" @default.
• W4224443432 creator A5002358866 @default.
• W4224443432 creator A5009991971 @default.
• W4224443432 creator A5011257603 @default.
• W4224443432 creator A5018931849 @default.
• W4224443432 creator A5024801858 @default.
• W4224443432 creator A5027413545 @default.
• W4224443432 creator A5047165183 @default.
• W4224443432 creator A5058895291 @default.
• W4224443432 creator A5062394423 @default.
• W4224443432 creator A5066627346 @default.
• W4224443432 creator A5072657201 @default.
• W4224443432 date "2022-04-26" @default.
• W4224443432 modified "2023-10-10" @default.
• W4224443432 title "RAGE signaling during tobacco smoke-induced lung inflammation and potential therapeutic utility of SAGEs" @default.
• W4224443432 cites W16443402 @default.
• W4224443432 cites W1870141733 @default.
• W4224443432 cites W1963492502 @default.
• W4224443432 cites W1976525234 @default.
• W4224443432 cites W1979271070 @default.
• W4224443432 cites W1985775184 @default.
• W4224443432 cites W2020840750 @default.
• W4224443432 cites W2026859462 @default.
• W4224443432 cites W2032026196 @default.
• W4224443432 cites W2035127805 @default.
• W4224443432 cites W2053375738 @default.
• W4224443432 cites W2054055118 @default.
• W4224443432 cites W2071675524 @default.
• W4224443432 cites W2072752525 @default.
• W4224443432 cites W2077201251 @default.
• W4224443432 cites W2079515802 @default.
• W4224443432 cites W2087473460 @default.
• W4224443432 cites W2094333691 @default.
• W4224443432 cites W2098840758 @default.
• W4224443432 cites W2106949373 @default.
• W4224443432 cites W2109334664 @default.
• W4224443432 cites W2115293825 @default.
• W4224443432 cites W2117937531 @default.
• W4224443432 cites W2118354379 @default.
• W4224443432 cites W2125308937 @default.
• W4224443432 cites W2127327473 @default.
• W4224443432 cites W2143239934 @default.
• W4224443432 cites W2144015888 @default.
• W4224443432 cites W2144725045 @default.
• W4224443432 cites W2154194339 @default.
• W4224443432 cites W2163351331 @default.
• W4224443432 cites W2163550534 @default.
• W4224443432 cites W2166432084 @default.
• W4224443432 cites W2315092288 @default.
• W4224443432 cites W2335424366 @default.
• W4224443432 cites W2345055725 @default.
• W4224443432 cites W2416465887 @default.
• W4224443432 cites W2435288781 @default.
• W4224443432 cites W2571646230 @default.
• W4224443432 cites W2580491044 @default.
• W4224443432 cites W2611047521 @default.
• W4224443432 cites W2614743634 @default.
• W4224443432 cites W2735702814 @default.
• W4224443432 cites W2859606301 @default.
• W4224443432 cites W2885281818 @default.
• W4224443432 cites W2896882073 @default.
• W4224443432 cites W2971896608 @default.
• W4224443432 cites W3098459487 @default.
• W4224443432 cites W4240182676 @default.
• W4224443432 cites W4300201302 @default.
• W4224443432 cites W4302780662 @default.
• W4224443432 doi "https://doi.org/10.1186/s12890-022-01935-x" @default.
• W4224443432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35473605" @default.
• W4224443432 hasPublicationYear "2022" @default.
• W4224443432 type Work @default.
• W4224443432 citedByCount "1" @default.
• W4224443432 countsByYear W42244434322023 @default.
• W4224443432 crossrefType "journal-article" @default.
• W4224443432 hasAuthorship W4224443432A5002358866 @default.
• W4224443432 hasAuthorship W4224443432A5009991971 @default.
• W4224443432 hasAuthorship W4224443432A5011257603 @default.
• W4224443432 hasAuthorship W4224443432A5018931849 @default.
• W4224443432 hasAuthorship W4224443432A5024801858 @default.
• W4224443432 hasAuthorship W4224443432A5027413545 @default.
• W4224443432 hasAuthorship W4224443432A5047165183 @default.
• W4224443432 hasAuthorship W4224443432A5058895291 @default.
• W4224443432 hasAuthorship W4224443432A5062394423 @default.
• W4224443432 hasAuthorship W4224443432A5066627346 @default.
• W4224443432 hasAuthorship W4224443432A5072657201 @default.
• W4224443432 hasBestOaLocation W42244434321 @default.
• W4224443432 hasConcept C126322002 @default.
• W4224443432 hasConcept C134018914 @default.
• W4224443432 hasConcept C169760540 @default.
• W4224443432 hasConcept C203014093 @default.
• W4224443432 hasConcept C2776914184 @default.
• W4224443432 hasConcept C2777714996 @default.
• W4224443432 hasConcept C2777961210 @default.
• W4224443432 hasConcept C2778857457 @default.
• W4224443432 hasConcept C71924100 @default.
• W4224443432 hasConcept C86803240 @default.
• W4224443432 hasConceptScore W4224443432C126322002 @default.
• W4224443432 hasConceptScore W4224443432C134018914 @default.
• W4224443432 hasConceptScore W4224443432C169760540 @default.
• W4224443432 hasConceptScore W4224443432C203014093 @default.

• next