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• W4224451661 abstract "Abstract Lineage switch is a rare event at leukemic relapse. While mostly known to occur in KMT2A ‐rearranged infant leukemia, the underlying mechanism is yet to be depicted. This case report describes a female infant who achieved remission of KMT2A ‐ MLLT3 ‐rearranged acute monocytic leukemia, but 6 months thereafter, relapsed as KMT2A ‐ MLLT3 ‐rearranged acute lymphocytic leukemia. Whole exome sequencing of the bone marrow obtained pre‐post lineage switch revealed two somatic mutations of PAX5 in the relapse sample. These two PAX5 alterations were suggested to be loss of function, thus to have played the driver role in the lineage switch from acute monocytic leukemia to acute lymphocytic leukemia." @default.
• W4224451661 created "2022-04-27" @default.
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• W4224451661 date "2022-05-31" @default.
• W4224451661 modified "2023-10-14" @default.
• W4224451661 title "<i>PAX5</i> alterations in an infant case of <i>KMT2A</i>‐rearranged leukemia with lineage switch" @default.
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• W4224451661 doi "https://doi.org/10.1111/cas.15380" @default.
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