Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224482821> ?p ?o ?g. }
- W4224482821 endingPage "128747" @default.
- W4224482821 startingPage "128747" @default.
- W4224482821 abstract "For developing novel therapeutic agents with good anticancer activities, a series of novel pyridine-pyrimidine hybrid phosphonate derivatives4(a-q) were synthesized by the Kabachnik-Fields method using CAN as catalyst. The compound 4o exhibited the most potent anticancer activity with an IC50 value of 13.62 μM, 17.49 μM, 5.81 μM, 1.59 μM and 2.11 μM against selected cancer cell lines A549, Hep-G2, HeLa, MCF-7, and HL-60, respectively. Compound 4o displayed seven times more selectivity towards Hep-G2 cancer cell lines compared to the human normal hepatocyte cell line LO2 (IC50 value 95.33 μM). Structure-Activity Relationship (SAR) studies were conducted on the variation in the aromatic ring (five-membered heterocyclic ring, six-membered heterocyclic ring) and the variation of substituents on the phenyl ring (electron donating groups, electron withdrawing groups). Furthermore, the mechanism of anticancer activity was clarified by further explorations in bioactivity by using in vitro aurora kinase inhibitory activity and molecular docking studies. The results showed that the compound 4o at IC50concentrationdemonstrated distinctive morphological changes such as cell detachment, cell wall deformation, cell shrinkage and reduced number of viable cells in cancer cell lines. Compound 4o induced early apoptosis and late apoptosis of 27.7% and 6.1% respectively." @default.
- W4224482821 created "2022-04-27" @default.
- W4224482821 creator A5010213491 @default.
- W4224482821 creator A5023523570 @default.
- W4224482821 creator A5044715280 @default.
- W4224482821 creator A5072222831 @default.
- W4224482821 creator A5086638792 @default.
- W4224482821 creator A5088821562 @default.
- W4224482821 creator A5090542131 @default.
- W4224482821 creator A5091323412 @default.
- W4224482821 date "2022-07-01" @default.
- W4224482821 modified "2023-10-14" @default.
- W4224482821 title "Explorations of novel pyridine-pyrimidine hybrid phosphonate derivatives as aurora kinase inhibitors" @default.
- W4224482821 cites W1968371447 @default.
- W4224482821 cites W1981717620 @default.
- W4224482821 cites W1982360304 @default.
- W4224482821 cites W2004717523 @default.
- W4224482821 cites W2019693704 @default.
- W4224482821 cites W2027016620 @default.
- W4224482821 cites W2028629022 @default.
- W4224482821 cites W2031758700 @default.
- W4224482821 cites W2038657030 @default.
- W4224482821 cites W2049097780 @default.
- W4224482821 cites W2079971744 @default.
- W4224482821 cites W2085888145 @default.
- W4224482821 cites W2097246559 @default.
- W4224482821 cites W2131647344 @default.
- W4224482821 cites W2225159543 @default.
- W4224482821 cites W2317774604 @default.
- W4224482821 cites W2322916838 @default.
- W4224482821 cites W2378209437 @default.
- W4224482821 cites W2552689420 @default.
- W4224482821 cites W2559067936 @default.
- W4224482821 cites W2617729814 @default.
- W4224482821 cites W2626252405 @default.
- W4224482821 cites W2731480559 @default.
- W4224482821 cites W2740766161 @default.
- W4224482821 cites W2766410692 @default.
- W4224482821 cites W2794040647 @default.
- W4224482821 cites W2794072994 @default.
- W4224482821 cites W2801113596 @default.
- W4224482821 cites W2801966983 @default.
- W4224482821 cites W2886665889 @default.
- W4224482821 cites W2887526041 @default.
- W4224482821 cites W2889646458 @default.
- W4224482821 cites W2891147283 @default.
- W4224482821 cites W2897423284 @default.
- W4224482821 cites W2943185265 @default.
- W4224482821 cites W618564271 @default.
- W4224482821 doi "https://doi.org/10.1016/j.bmcl.2022.128747" @default.
- W4224482821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35476959" @default.
- W4224482821 hasPublicationYear "2022" @default.
- W4224482821 type Work @default.
- W4224482821 citedByCount "2" @default.
- W4224482821 countsByYear W42244828212022 @default.
- W4224482821 countsByYear W42244828212023 @default.
- W4224482821 crossrefType "journal-article" @default.
- W4224482821 hasAuthorship W4224482821A5010213491 @default.
- W4224482821 hasAuthorship W4224482821A5023523570 @default.
- W4224482821 hasAuthorship W4224482821A5044715280 @default.
- W4224482821 hasAuthorship W4224482821A5072222831 @default.
- W4224482821 hasAuthorship W4224482821A5086638792 @default.
- W4224482821 hasAuthorship W4224482821A5088821562 @default.
- W4224482821 hasAuthorship W4224482821A5090542131 @default.
- W4224482821 hasAuthorship W4224482821A5091323412 @default.
- W4224482821 hasConcept C1491633281 @default.
- W4224482821 hasConcept C155647269 @default.
- W4224482821 hasConcept C159110408 @default.
- W4224482821 hasConcept C184235292 @default.
- W4224482821 hasConcept C185592680 @default.
- W4224482821 hasConcept C190283241 @default.
- W4224482821 hasConcept C202751555 @default.
- W4224482821 hasConcept C2777366897 @default.
- W4224482821 hasConcept C2777626080 @default.
- W4224482821 hasConcept C2777752497 @default.
- W4224482821 hasConcept C2779321679 @default.
- W4224482821 hasConcept C2779485729 @default.
- W4224482821 hasConcept C29537977 @default.
- W4224482821 hasConcept C41685203 @default.
- W4224482821 hasConcept C54355233 @default.
- W4224482821 hasConcept C55493867 @default.
- W4224482821 hasConcept C62112901 @default.
- W4224482821 hasConcept C71240020 @default.
- W4224482821 hasConcept C71924100 @default.
- W4224482821 hasConcept C81885089 @default.
- W4224482821 hasConcept C86803240 @default.
- W4224482821 hasConceptScore W4224482821C1491633281 @default.
- W4224482821 hasConceptScore W4224482821C155647269 @default.
- W4224482821 hasConceptScore W4224482821C159110408 @default.
- W4224482821 hasConceptScore W4224482821C184235292 @default.
- W4224482821 hasConceptScore W4224482821C185592680 @default.
- W4224482821 hasConceptScore W4224482821C190283241 @default.
- W4224482821 hasConceptScore W4224482821C202751555 @default.
- W4224482821 hasConceptScore W4224482821C2777366897 @default.
- W4224482821 hasConceptScore W4224482821C2777626080 @default.
- W4224482821 hasConceptScore W4224482821C2777752497 @default.
- W4224482821 hasConceptScore W4224482821C2779321679 @default.
- W4224482821 hasConceptScore W4224482821C2779485729 @default.