FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224627793> ?p ?o ?g. }

• W4224627793 abstract "Abstract Vaccine is the main public health measure to reduce SARS-CoV-2 transmission and hospitalization, and a massive scientific effort worldwide resulted in the rapid development of effective vaccines. This work aimed to define the dynamics and persistence of humoral and cell-mediated immune response in Health Care Workers who received a two-dose BNT162b2-mRNA vaccination. Serological response was evaluated by quantifying anti-RBD and neutralizing antibodies while cell-mediated response was performed by a whole blood test quantifying Th1 cytokines (IFN-γ, TNF-α, IL-2) produced in response to Spike peptides. BNT162b2-mRNA vaccine induced both humoral and cell-mediated immune response against Spike in all HCW early after the second dose. After 12 weeks from vaccination, the titer of anti-RBD antibodies as well as their neutralization function decreased while the Spike-specific T-cells persisted at the same level as soon after vaccine boost. Of note, a correlation between cellular and humoral response persevered, suggesting the persistence of a coordinated immune response. The long lasting cell-mediated immune response after 3 months from vaccination highlight its importance in the maintaining of specific immunity able to expand again to fight eventual new antigen encountering." @default.
• W4224627793 created "2022-04-27" @default.
• W4224627793 creator A5000658040 @default.
• W4224627793 creator A5001272995 @default.
• W4224627793 creator A5002809468 @default.
• W4224627793 creator A5003065885 @default.
• W4224627793 creator A5005276701 @default.
• W4224627793 creator A5011607876 @default.
• W4224627793 creator A5013551429 @default.
• W4224627793 creator A5014256431 @default.
• W4224627793 creator A5015005137 @default.
• W4224627793 creator A5016455754 @default.
• W4224627793 creator A5017573435 @default.
• W4224627793 creator A5019493690 @default.
• W4224627793 creator A5021844447 @default.
• W4224627793 creator A5022221639 @default.
• W4224627793 creator A5026359088 @default.
• W4224627793 creator A5029464689 @default.
• W4224627793 creator A5030152118 @default.
• W4224627793 creator A5044105605 @default.
• W4224627793 creator A5045554714 @default.
• W4224627793 creator A5046686203 @default.
• W4224627793 creator A5057636986 @default.
• W4224627793 creator A5058381480 @default.
• W4224627793 creator A5068377872 @default.
• W4224627793 creator A5070315857 @default.
• W4224627793 creator A5075193784 @default.
• W4224627793 creator A5075693717 @default.
• W4224627793 creator A5078608594 @default.
• W4224627793 creator A5078816295 @default.
• W4224627793 creator A5080484418 @default.
• W4224627793 creator A5084138547 @default.
• W4224627793 creator A5086692767 @default.
• W4224627793 creator A5086824050 @default.
• W4224627793 date "2022-04-23" @default.
• W4224627793 modified "2023-10-14" @default.
• W4224627793 title "Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccine" @default.
• W4224627793 cites W2039781676 @default.
• W4224627793 cites W3039276601 @default.
• W4224627793 cites W3048775784 @default.
• W4224627793 cites W3082438395 @default.
• W4224627793 cites W3084879098 @default.
• W4224627793 cites W3111255098 @default.
• W4224627793 cites W3121008609 @default.
• W4224627793 cites W3126915713 @default.
• W4224627793 cites W3128918508 @default.
• W4224627793 cites W3141986261 @default.
• W4224627793 cites W3147135382 @default.
• W4224627793 cites W3154559123 @default.
• W4224627793 cites W3167296513 @default.
• W4224627793 cites W3169559522 @default.
• W4224627793 cites W3194838263 @default.
• W4224627793 cites W3211947794 @default.
• W4224627793 doi "https://doi.org/10.1038/s41598-022-07741-z" @default.
• W4224627793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35461335" @default.
• W4224627793 hasPublicationYear "2022" @default.
• W4224627793 type Work @default.
• W4224627793 citedByCount "21" @default.
• W4224627793 countsByYear W42246277932022 @default.
• W4224627793 countsByYear W42246277932023 @default.
• W4224627793 crossrefType "journal-article" @default.
• W4224627793 hasAuthorship W4224627793A5000658040 @default.
• W4224627793 hasAuthorship W4224627793A5001272995 @default.
• W4224627793 hasAuthorship W4224627793A5002809468 @default.
• W4224627793 hasAuthorship W4224627793A5003065885 @default.
• W4224627793 hasAuthorship W4224627793A5005276701 @default.
• W4224627793 hasAuthorship W4224627793A5011607876 @default.
• W4224627793 hasAuthorship W4224627793A5013551429 @default.
• W4224627793 hasAuthorship W4224627793A5014256431 @default.
• W4224627793 hasAuthorship W4224627793A5015005137 @default.
• W4224627793 hasAuthorship W4224627793A5016455754 @default.
• W4224627793 hasAuthorship W4224627793A5017573435 @default.
• W4224627793 hasAuthorship W4224627793A5019493690 @default.
• W4224627793 hasAuthorship W4224627793A5021844447 @default.
• W4224627793 hasAuthorship W4224627793A5022221639 @default.
• W4224627793 hasAuthorship W4224627793A5026359088 @default.
• W4224627793 hasAuthorship W4224627793A5029464689 @default.
• W4224627793 hasAuthorship W4224627793A5030152118 @default.
• W4224627793 hasAuthorship W4224627793A5044105605 @default.
• W4224627793 hasAuthorship W4224627793A5045554714 @default.
• W4224627793 hasAuthorship W4224627793A5046686203 @default.
• W4224627793 hasAuthorship W4224627793A5057636986 @default.
• W4224627793 hasAuthorship W4224627793A5058381480 @default.
• W4224627793 hasAuthorship W4224627793A5068377872 @default.
• W4224627793 hasAuthorship W4224627793A5070315857 @default.
• W4224627793 hasAuthorship W4224627793A5075193784 @default.
• W4224627793 hasAuthorship W4224627793A5075693717 @default.
• W4224627793 hasAuthorship W4224627793A5078608594 @default.
• W4224627793 hasAuthorship W4224627793A5078816295 @default.
• W4224627793 hasAuthorship W4224627793A5080484418 @default.
• W4224627793 hasAuthorship W4224627793A5084138547 @default.
• W4224627793 hasAuthorship W4224627793A5086692767 @default.
• W4224627793 hasAuthorship W4224627793A5086824050 @default.
• W4224627793 hasBestOaLocation W42246277931 @default.
• W4224627793 hasConcept C159047783 @default.
• W4224627793 hasConcept C159654299 @default.
• W4224627793 hasConcept C203014093 @default.
• W4224627793 hasConcept C22070199 @default.
• W4224627793 hasConcept C2776548049 @default.
• W4224627793 hasConcept C2779261636 @default.

• next