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- W4224815538 abstract "Cancer drug resistance presents a major barrier to continued successful treatment of malignancies. Current therapies inhibiting proteins indicated in cancer progression are consistently found to lose efficacy as a result of acquired drug resistance, often caused by mutated or overexpressed protein targets. By hijacking the cellular ubiquitin-proteasome protein degradation machinery, proteolysis-targeting chimeras (PROTACs) offer an alternative therapeutic modality to cancer treatments with various potential advantages. PROTACs specific for a number of known cancer targets have been developed in the last 5 years, which present new options for remission in patients with previously untreatable malignancies and provide a foundation for future-generation compounds. One notable advantage of PROTACs, supported by evidence from a number of recent studies, is that they can overcome some of the resistance mechanisms to traditional targeted therapies. More recently, some groups have begun researching the use of PROTACs to successfully degrade mutated targets conferring cancer resistance against first-line treatments. In this review, we focus on analyzing the developments in PROTACs geared towards cancer resistance and targets that confer it in the search for new and successful therapies." @default.
- W4224815538 created "2022-04-27" @default.
- W4224815538 creator A5040538641 @default.
- W4224815538 creator A5058794772 @default.
- W4224815538 creator A5075672118 @default.
- W4224815538 date "2022-04-25" @default.
- W4224815538 modified "2023-09-30" @default.
- W4224815538 title "Overcoming Cancer Drug Resistance Utilizing PROTAC Technology" @default.
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