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- W4224862573 abstract "Abstract We investigated the differences in quantity and quality of skeletal muscle between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) individuals using abdominal CT. One hundred and seventy-two morbidly obese individuals who underwent bariatric surgery and 64 healthy control individuals participated in this retrospective study. We divided the obese individuals into an MHO and MUO group. CT evaluation of muscle quantity (at the level of the third lumbar vertebra [L3]) was performed by calculating muscle cross-sectional area (CSA), which was normalized to patient height to produce skeletal muscle index (SMI). Muscle quality was assessed as skeletal muscle density (SMD), which was calculated from CT muscle attenuation. To characterize intramuscular composition, muscle attenuation was classified into three categories using Hounsfield unit (HU) thresholds: -190 HU to -30 HU for intermuscular adipose tissue (IMAT), -29 to + 29 HU for low attenuation muscle (LAM), and + 30 to + 150 HU for normal attenuation muscle (NAM). Morbidly obese individuals comprised 24 (14%) MHO individuals and 148 (86%) MUO individuals. The mean age of the participants was 39.7 ± 12.5 years, and 154 (65%) participants were women. MUO individuals had a significantly greater total skeletal muscle CSA than MHO individuals in the model that adjusted for all variables. Total skeletal muscle SMI, SMD, NAM index, LAM index, and IMAT index did not differ between MHO and MUO individuals for all adjusted models. Total skeletal muscle at the L3 level was not different in muscle quantity, quality, or intramuscular composition between the MHO and MUO individuals, based on CT evaluation." @default.
- W4224862573 created "2022-04-27" @default.
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- W4224862573 date "2022-04-25" @default.
- W4224862573 modified "2023-09-29" @default.
- W4224862573 title "Computed tomography evaluation of skeletal muscle quality and quantity in morbidly obese individuals with and without metabolic abnormality" @default.
- W4224862573 doi "https://doi.org/10.21203/rs.3.rs-1552951/v1" @default.
- W4224862573 hasPublicationYear "2022" @default.
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