Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224864454> ?p ?o ?g. }
- W4224864454 abstract "Klebsiella pneumoniae simultaneously carrying genes encoding carbapenem resistance and hypervirulence causes fatal infections, representing a severe threat to human health. These carbapenem-resistant and hypervirulent K. pneumoniae (hvCRKP) strains are increasingly reported worldwide and have been found to belong to a variety of sequence types (STs). In this study, we report and characterized an hvCRKP strain of ST592, an uncommon ST, which caused a fatal infection in intensive care unit (ICU) in China and represents a novel type of hvCRKP. We demonstrated that this novel hvCRKP type emerged from the carbapenem-susceptible hypervirulent K. pneumoniae (hvKP) lineage of the K57 capsular type. K57 hvKP contains a pLVPK-like virulence plasmid and then acquired a conjugative bla KPC–2 -carrying plasmid to form hvCRKP. The pLVPK-like virulence plasmid contains no complete conjugation module but was able to be transferred by fusion with the conjugative bla KPC–2 -carrying plasmid during conjugation. This represents a new mechanism of simultaneous transfer genetic determinants of carbapenem resistance and virulence and highlights the undergoing expansion of hvCRKP, which requires rigorous monitoring and novel countermeasures to curb plasmid-mediated transmission." @default.
- W4224864454 created "2022-04-27" @default.
- W4224864454 creator A5005691727 @default.
- W4224864454 creator A5023200478 @default.
- W4224864454 creator A5050657514 @default.
- W4224864454 date "2022-04-25" @default.
- W4224864454 modified "2023-10-14" @default.
- W4224864454 title "Conjugation of a Hybrid Plasmid Encoding Hypervirulence and Carbapenem Resistance in Klebsiella pneumoniae of Sequence Type 592" @default.
- W4224864454 cites W1967015083 @default.
- W4224864454 cites W1985898558 @default.
- W4224864454 cites W1991331030 @default.
- W4224864454 cites W2022935203 @default.
- W4224864454 cites W2023508019 @default.
- W4224864454 cites W2024168261 @default.
- W4224864454 cites W2064419538 @default.
- W4224864454 cites W2091030812 @default.
- W4224864454 cites W2099592222 @default.
- W4224864454 cites W2106788891 @default.
- W4224864454 cites W2108312133 @default.
- W4224864454 cites W2108773674 @default.
- W4224864454 cites W2109529827 @default.
- W4224864454 cites W2128789609 @default.
- W4224864454 cites W2128884353 @default.
- W4224864454 cites W2136670217 @default.
- W4224864454 cites W2146266399 @default.
- W4224864454 cites W2162824445 @default.
- W4224864454 cites W2584169226 @default.
- W4224864454 cites W2789652364 @default.
- W4224864454 cites W2887376036 @default.
- W4224864454 cites W2905909361 @default.
- W4224864454 cites W2937685376 @default.
- W4224864454 cites W2945505394 @default.
- W4224864454 cites W2950284789 @default.
- W4224864454 cites W2976936331 @default.
- W4224864454 cites W2986910725 @default.
- W4224864454 cites W2995856789 @default.
- W4224864454 cites W2996498210 @default.
- W4224864454 cites W3005039565 @default.
- W4224864454 cites W3005759147 @default.
- W4224864454 cites W3028438231 @default.
- W4224864454 cites W3035521179 @default.
- W4224864454 cites W3048219319 @default.
- W4224864454 cites W3103408991 @default.
- W4224864454 cites W3136406161 @default.
- W4224864454 cites W3136455567 @default.
- W4224864454 cites W3165427382 @default.
- W4224864454 cites W3186091856 @default.
- W4224864454 cites W3188173177 @default.
- W4224864454 cites W4205116116 @default.
- W4224864454 cites W4231556147 @default.
- W4224864454 doi "https://doi.org/10.3389/fmicb.2022.852596" @default.
- W4224864454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35558122" @default.
- W4224864454 hasPublicationYear "2022" @default.
- W4224864454 type Work @default.
- W4224864454 citedByCount "2" @default.
- W4224864454 countsByYear W42248644542022 @default.
- W4224864454 crossrefType "journal-article" @default.
- W4224864454 hasAuthorship W4224864454A5005691727 @default.
- W4224864454 hasAuthorship W4224864454A5023200478 @default.
- W4224864454 hasAuthorship W4224864454A5050657514 @default.
- W4224864454 hasBestOaLocation W42248644541 @default.
- W4224864454 hasConcept C104317684 @default.
- W4224864454 hasConcept C159047783 @default.
- W4224864454 hasConcept C22744801 @default.
- W4224864454 hasConcept C2776817793 @default.
- W4224864454 hasConcept C2777058267 @default.
- W4224864454 hasConcept C54355233 @default.
- W4224864454 hasConcept C547475151 @default.
- W4224864454 hasConcept C60987743 @default.
- W4224864454 hasConcept C86803240 @default.
- W4224864454 hasConcept C89423630 @default.
- W4224864454 hasConceptScore W4224864454C104317684 @default.
- W4224864454 hasConceptScore W4224864454C159047783 @default.
- W4224864454 hasConceptScore W4224864454C22744801 @default.
- W4224864454 hasConceptScore W4224864454C2776817793 @default.
- W4224864454 hasConceptScore W4224864454C2777058267 @default.
- W4224864454 hasConceptScore W4224864454C54355233 @default.
- W4224864454 hasConceptScore W4224864454C547475151 @default.
- W4224864454 hasConceptScore W4224864454C60987743 @default.
- W4224864454 hasConceptScore W4224864454C86803240 @default.
- W4224864454 hasConceptScore W4224864454C89423630 @default.
- W4224864454 hasFunder F4320321001 @default.
- W4224864454 hasLocation W42248644541 @default.
- W4224864454 hasLocation W42248644542 @default.
- W4224864454 hasLocation W42248644543 @default.
- W4224864454 hasLocation W42248644544 @default.
- W4224864454 hasOpenAccess W4224864454 @default.
- W4224864454 hasPrimaryLocation W42248644541 @default.
- W4224864454 hasRelatedWork W1932581149 @default.
- W4224864454 hasRelatedWork W2092219958 @default.
- W4224864454 hasRelatedWork W2228167218 @default.
- W4224864454 hasRelatedWork W2318106903 @default.
- W4224864454 hasRelatedWork W2976936331 @default.
- W4224864454 hasRelatedWork W3136406161 @default.
- W4224864454 hasRelatedWork W3197662337 @default.
- W4224864454 hasRelatedWork W3212473823 @default.
- W4224864454 hasRelatedWork W4280562914 @default.
- W4224864454 hasRelatedWork W4286716365 @default.
- W4224864454 hasVolume "13" @default.
- W4224864454 isParatext "false" @default.