FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224871124> ?p ?o ?g. }

• W4224871124 abstract "Abstract Background and Aims Nonstructural (NS1) protein is mainly involved in virulence and replication of several viruses, including influenza virus A (H1N1); surveillance of the latter started in India in 2009. The objective of this study was to identify the new substitutions in NS1 protein from the influenza virus A (H1N1) pandemic 2009 (pdm09) strain isolated in India. Methods The sequences of NS1 proteins from influenza A(H1N1) pdm09 strains isolated in India were obtained from publicly available databases. Multiple sequence alignment and phylogeny analyses were performed to confirm the “consistent substitutions” on NS1 protein from H1N1 (pdm09) Indian strains. Here, “consistent substitutions” were defined as the substitutions observed in all the sequences isolated in a year. Comparative analyses were performed among NS1 Indian sequences from A(H1N1) pdm09, A (H1N1) seasonal and A(H3N2) strains, and from A (H1N1) pdm09 global strains. Results Eight substitutions were identified in the NS1 Indian sequence from the A(H1N1) pdm09 strain, two in RBD, five in ED, and one in the linker region. Three new substitutions were reported in this study at NS1 sequence positions 2, 80, and 155, which evolved within 2015–2019 and became “consistent.” These new substitutions were associated with conservative paired substitutions in the alternative domains of the NS1 protein. Three paired substitutions were (i) D2E and E125D, (ii) T80A and A155T, and (iii) E55K and K131E. Conclusions This study indicates the continuous evolution of NS1 protein from the influenza A virus. The new substitutions at positions 2 and 80 occurred in the RNA binding and eIF4GI binding domains. The D2E substitution evolved simultaneously with the E125D substitution that involved viral replication. The third new substitution at position 155 occurred in the PI3K binding domain. The possible consequences of these substitutions on host–pathogen interactions are subject to further experimental and computational verification." @default.
• W4224871124 created "2022-04-27" @default.
• W4224871124 creator A5003482074 @default.
• W4224871124 creator A5006782201 @default.
• W4224871124 creator A5019328322 @default.
• W4224871124 creator A5038190499 @default.
• W4224871124 creator A5039539181 @default.
• W4224871124 creator A5040130527 @default.
• W4224871124 date "2022-04-25" @default.
• W4224871124 modified "2023-09-30" @default.
• W4224871124 title "New substitutions on NS1 protein from influenza A (H1N1) virus: Bioinformatics analyses of Indian strains isolated from 2009 to 2020" @default.
• W4224871124 cites W1507193758 @default.
• W4224871124 cites W1839421179 @default.
• W4224871124 cites W1854023115 @default.
• W4224871124 cites W188497742 @default.
• W4224871124 cites W1968895930 @default.
• W4224871124 cites W1975123527 @default.
• W4224871124 cites W1983872969 @default.
• W4224871124 cites W1988533731 @default.
• W4224871124 cites W1995550922 @default.
• W4224871124 cites W1999352184 @default.
• W4224871124 cites W2004586645 @default.
• W4224871124 cites W2017519756 @default.
• W4224871124 cites W2032413714 @default.
• W4224871124 cites W2049885346 @default.
• W4224871124 cites W2050611351 @default.
• W4224871124 cites W2054668663 @default.
• W4224871124 cites W2056165940 @default.
• W4224871124 cites W2057077533 @default.
• W4224871124 cites W2061032348 @default.
• W4224871124 cites W2067210365 @default.
• W4224871124 cites W2074061005 @default.
• W4224871124 cites W2081308293 @default.
• W4224871124 cites W2089911961 @default.
• W4224871124 cites W2092708000 @default.
• W4224871124 cites W2110214166 @default.
• W4224871124 cites W2113162618 @default.
• W4224871124 cites W2114142573 @default.
• W4224871124 cites W2118551141 @default.
• W4224871124 cites W2121009566 @default.
• W4224871124 cites W2121260217 @default.
• W4224871124 cites W2125121305 @default.
• W4224871124 cites W2126303830 @default.
• W4224871124 cites W2129148489 @default.
• W4224871124 cites W2136125021 @default.
• W4224871124 cites W2137015675 @default.
• W4224871124 cites W2137378887 @default.
• W4224871124 cites W2138468856 @default.
• W4224871124 cites W2156125289 @default.
• W4224871124 cites W2160898409 @default.
• W4224871124 cites W2170747616 @default.
• W4224871124 cites W2297470371 @default.
• W4224871124 cites W2471702076 @default.
• W4224871124 cites W2587970647 @default.
• W4224871124 cites W2605343262 @default.
• W4224871124 cites W2684569529 @default.
• W4224871124 cites W2740784254 @default.
• W4224871124 cites W2799524357 @default.
• W4224871124 cites W2944745527 @default.
• W4224871124 cites W2990617443 @default.
• W4224871124 cites W3011552450 @default.
• W4224871124 cites W3014240606 @default.
• W4224871124 cites W3021133704 @default.
• W4224871124 cites W3022950950 @default.
• W4224871124 cites W3033689290 @default.
• W4224871124 cites W3083624561 @default.
• W4224871124 cites W3093030757 @default.
• W4224871124 cites W3122601918 @default.
• W4224871124 cites W3122865446 @default.
• W4224871124 cites W3127173946 @default.
• W4224871124 cites W3134476645 @default.
• W4224871124 cites W4224871124 @default.
• W4224871124 doi "https://doi.org/10.1002/hsr2.626" @default.
• W4224871124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35509388" @default.
• W4224871124 hasPublicationYear "2022" @default.
• W4224871124 type Work @default.
• W4224871124 citedByCount "1" @default.
• W4224871124 countsByYear W42248711242022 @default.
• W4224871124 crossrefType "journal-article" @default.
• W4224871124 hasAuthorship W4224871124A5003482074 @default.
• W4224871124 hasAuthorship W4224871124A5006782201 @default.
• W4224871124 hasAuthorship W4224871124A5019328322 @default.
• W4224871124 hasAuthorship W4224871124A5038190499 @default.
• W4224871124 hasAuthorship W4224871124A5039539181 @default.
• W4224871124 hasAuthorship W4224871124A5040130527 @default.
• W4224871124 hasBestOaLocation W42248711241 @default.
• W4224871124 hasConcept C104317684 @default.
• W4224871124 hasConcept C105702510 @default.
• W4224871124 hasConcept C142724271 @default.
• W4224871124 hasConcept C159047783 @default.
• W4224871124 hasConcept C16154277 @default.
• W4224871124 hasConcept C193252679 @default.
• W4224871124 hasConcept C2522874641 @default.
• W4224871124 hasConcept C2777546802 @default.
• W4224871124 hasConcept C2778022156 @default.
• W4224871124 hasConcept C2779134260 @default.
• W4224871124 hasConcept C3008058167 @default.
• W4224871124 hasConcept C524204448 @default.
• W4224871124 hasConcept C54355233 @default.
• W4224871124 hasConcept C60987743 @default.

• next