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- W4224880003 abstract "Iberdomide, a ubiquitin ligase modulator that promotes degradation of the B-cell transcription factors Ikaros and Aiolos, might be a safe and effective therapeutic option for patients with systemic lupus erythematosus (SLE), according to a phase 2, double-blind, randomised trial. Joan Merrill and colleagues randomly assigned 288 patients (2:2:1:2) to receive 0·45 mg (n=81), 0·30 mg (n=82), or 0·15 mg (n=42) oral iberdomide, or placebo (n=83), once daily for 24 weeks, in addition to standard medications. At week 24, 44 (54%) of 81 patients in the iberdomide 0·45 mg group achieved the primary outcome of an SLE Responder Index (SRI)-4 response (a reduction of ≥4 points on the SLE Disease Activity Index 2000, no new disease activity, and no increase of ≥0.3 points on Physician's Global Assessment score) compared with 29 (35%) of 83 in the placebo group (adjusted difference 19·4%; 95% CI 4·1–33·4; p=0·01). SRI-4 responses did not differ significantly between the lower dose iberdomide groups and placebo (33 [40%] on 0·30 mg; 20 [48%] on 0·15 mg). 63 (78%) patients on iberdomide 0·45 mg, 64 (78%) on 0·30 mg, 31 (74%) on 0·15 mg, and 54 (65%) on placebo reported at least one adverse event; the most frequent adverse events in the iberdomide groups were urinary tract and upper respiratory tract infections and neutropenia." @default.
- W4224880003 created "2022-04-27" @default.
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- W4224880003 date "2022-05-01" @default.
- W4224880003 modified "2023-09-30" @default.
- W4224880003 title "Research in Brief" @default.
- W4224880003 doi "https://doi.org/10.1016/s2665-9913(22)00104-7" @default.
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