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- W4224880022 abstract "In wound treatment, severe bleeding and infection are always primary challenges. Therefore, it is highly desired to develop novel dressing with both hemostatic and antibacterial capability. Herein, a series of biocomposite hemostatic films (BHFs) based alginate/chitosan/collagen-berberine have been prepared and well characterized for further biofunctional study. We have demonstrated that the hemostatic and antibacterial activities were significantly enhanced by calcium/berberine dual-crosslinking system in the film. Through the synergistic effects, BHF-6B exhibited a shorter in vivo clotting and wound healing time than that of commercial dressing in rat tail amputation and full-thickness skin defect models. Additionally, BHF-6B showed excellent bacteriostatic activity with long-term effects. Moreover, hemolysis and cytotoxicity tests in vitro illustrated the prominent biocompatibility of the composite films. Notably, BHF-6B could be degraded quickly and completely in vivo. Overall, the present work indicated that the functionalized BHF-6B has great potential as an absorbable biomaterial for wound treatment." @default.
- W4224880022 created "2022-04-27" @default.
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- W4224880022 date "2022-06-01" @default.
- W4224880022 modified "2023-09-30" @default.
- W4224880022 title "Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing" @default.
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- W4224880022 doi "https://doi.org/10.1016/j.ijbiomac.2022.04.132" @default.
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