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• W4224881276 abstract "Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce. The relationship between NAD+ signaling and heart aging has yet to be clarified. This review comprehensively summarizes the current studies on the role of NAD+ signaling in delaying heart aging from the following aspects: the influence of NAD+ supplementations on the aging heart; the relationship and cross-talks between NAD+ signaling and other cardiac aging-related signaling pathways; Importantly, the therapeutic potential of targeting NAD+ in delaying heart aging will be discussed. In brief, NAD+ plays a vital role in delaying heart aging. However, the abnormalities such as altered glucose and lipid metabolism, oxidative stress, and calcium overload could also interfere with NAD+ function in the heart. Therefore, the specific physiopathology of the aging heart should be considered before applying NAD+ supplementations. We believe that this article will help augment our understanding of heart aging mechanisms. In the meantime, it provides invaluable insights into possible therapeutic strategies for preventing age-related heart diseases in clinical settings." @default.
• W4224881276 created "2022-04-27" @default.
• W4224881276 creator A5013293072 @default.
• W4224881276 creator A5014065826 @default.
• W4224881276 creator A5018050569 @default.
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• W4224881276 creator A5073816387 @default.
• W4224881276 creator A5088868060 @default.
• W4224881276 creator A5089198168 @default.
• W4224881276 date "2022-04-26" @default.
• W4224881276 modified "2023-10-15" @default.
• W4224881276 title "Targeting NAD+: is it a common strategy to delay heart aging?" @default.
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