FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224883699> ?p ?o ?g. }

• W4224883699 endingPage "162" @default.
• W4224883699 startingPage "156" @default.
• W4224883699 abstract "Analysis of circulating tumor DNA (ctDNA), also known as liquid biopsy, has been postulated to be a useful test in the prognostication, molecular profiling, and monitoring of cancer patients. In this series we aimed to analyze the concordance between the mutation status of formalin-fixed paraffin-embedded (FFPE) tumor samples and matched ctDNA, considering tumor molecular profiling as the gold standard technique.This retrospective study included cancer patients with complete diagnostics and gene mutations detected in a previous FFPE tumor tissue Next-Generation Sequencing (NGS) study with a matched frozen plasma sample available for an NGS ctDNA assay.Sixty patients were included, 24 with colorectal carcinoma (CRC) and 36 with non-small cell lung cancer (NSCLC). In 27.1% of ctDNA studies a new mutation not previously detected in the matched tumor was found. 11.9% of these ctDNA results had the potential to impact clinical management. Globally, the concordance rate between FFPE tumor samples and ctDNA was 44.4%. When tumors were stratified by stage, the concordance was 76.5%, 70%, 36.4%, and 0% in tumor stages IV, III, II, and I, respectively. ctDNA molecular profiles showed a good concordance rate in advanced stage tumors and identified undetected mutations in tumor tissues. In early tumor stages the concordance was low, casting doubt on the usefulness of ctDNA in these patients." @default.
• W4224883699 created "2022-04-27" @default.
• W4224883699 creator A5003988036 @default.
• W4224883699 creator A5007479781 @default.
• W4224883699 creator A5014026287 @default.
• W4224883699 creator A5023841501 @default.
• W4224883699 creator A5025314506 @default.
• W4224883699 creator A5028358291 @default.
• W4224883699 creator A5029742377 @default.
• W4224883699 creator A5034786133 @default.
• W4224883699 creator A5035657524 @default.
• W4224883699 creator A5049341345 @default.
• W4224883699 creator A5062022394 @default.
• W4224883699 creator A5070977364 @default.
• W4224883699 creator A5072992442 @default.
• W4224883699 creator A5087208515 @default.
• W4224883699 date "2022-07-01" @default.
• W4224883699 modified "2023-10-18" @default.
• W4224883699 title "Concordance analysis between liquid biopsy (ctDNA) and tumor DNA molecular profiles from panel-based next-generation sequencing" @default.
• W4224883699 cites W2027735722 @default.
• W4224883699 cites W2665877695 @default.
• W4224883699 cites W2747939174 @default.
• W4224883699 cites W2785259638 @default.
• W4224883699 cites W2790122515 @default.
• W4224883699 cites W2794302389 @default.
• W4224883699 cites W2909504913 @default.
• W4224883699 cites W2939485990 @default.
• W4224883699 cites W2973027385 @default.
• W4224883699 cites W2976188024 @default.
• W4224883699 cites W2990870977 @default.
• W4224883699 cites W3011066241 @default.
• W4224883699 cites W303319180 @default.
• W4224883699 cites W3087229737 @default.
• W4224883699 cites W3088621202 @default.
• W4224883699 cites W3101612322 @default.
• W4224883699 cites W3112752004 @default.
• W4224883699 cites W3161666351 @default.
• W4224883699 doi "https://doi.org/10.1016/j.patol.2022.01.001" @default.
• W4224883699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35779881" @default.
• W4224883699 hasPublicationYear "2022" @default.
• W4224883699 type Work @default.
• W4224883699 citedByCount "3" @default.
• W4224883699 countsByYear W42248836992023 @default.
• W4224883699 crossrefType "journal-article" @default.
• W4224883699 hasAuthorship W4224883699A5003988036 @default.
• W4224883699 hasAuthorship W4224883699A5007479781 @default.
• W4224883699 hasAuthorship W4224883699A5014026287 @default.
• W4224883699 hasAuthorship W4224883699A5023841501 @default.
• W4224883699 hasAuthorship W4224883699A5025314506 @default.
• W4224883699 hasAuthorship W4224883699A5028358291 @default.
• W4224883699 hasAuthorship W4224883699A5029742377 @default.
• W4224883699 hasAuthorship W4224883699A5034786133 @default.
• W4224883699 hasAuthorship W4224883699A5035657524 @default.
• W4224883699 hasAuthorship W4224883699A5049341345 @default.
• W4224883699 hasAuthorship W4224883699A5062022394 @default.
• W4224883699 hasAuthorship W4224883699A5070977364 @default.
• W4224883699 hasAuthorship W4224883699A5072992442 @default.
• W4224883699 hasAuthorship W4224883699A5087208515 @default.
• W4224883699 hasConcept C121608353 @default.
• W4224883699 hasConcept C126322002 @default.
• W4224883699 hasConcept C142724271 @default.
• W4224883699 hasConcept C143998085 @default.
• W4224883699 hasConcept C146357865 @default.
• W4224883699 hasConcept C151730666 @default.
• W4224883699 hasConcept C160798450 @default.
• W4224883699 hasConcept C179786068 @default.
• W4224883699 hasConcept C2775934546 @default.
• W4224883699 hasConcept C2776256026 @default.
• W4224883699 hasConcept C2779529041 @default.
• W4224883699 hasConcept C2781335228 @default.
• W4224883699 hasConcept C502942594 @default.
• W4224883699 hasConcept C526805850 @default.
• W4224883699 hasConcept C60644358 @default.
• W4224883699 hasConcept C71924100 @default.
• W4224883699 hasConcept C86803240 @default.
• W4224883699 hasConceptScore W4224883699C121608353 @default.
• W4224883699 hasConceptScore W4224883699C126322002 @default.
• W4224883699 hasConceptScore W4224883699C142724271 @default.
• W4224883699 hasConceptScore W4224883699C143998085 @default.
• W4224883699 hasConceptScore W4224883699C146357865 @default.
• W4224883699 hasConceptScore W4224883699C151730666 @default.
• W4224883699 hasConceptScore W4224883699C160798450 @default.
• W4224883699 hasConceptScore W4224883699C179786068 @default.
• W4224883699 hasConceptScore W4224883699C2775934546 @default.
• W4224883699 hasConceptScore W4224883699C2776256026 @default.
• W4224883699 hasConceptScore W4224883699C2779529041 @default.
• W4224883699 hasConceptScore W4224883699C2781335228 @default.
• W4224883699 hasConceptScore W4224883699C502942594 @default.
• W4224883699 hasConceptScore W4224883699C526805850 @default.
• W4224883699 hasConceptScore W4224883699C60644358 @default.
• W4224883699 hasConceptScore W4224883699C71924100 @default.
• W4224883699 hasConceptScore W4224883699C86803240 @default.
• W4224883699 hasIssue "3" @default.
• W4224883699 hasLocation W42248836991 @default.
• W4224883699 hasLocation W42248836992 @default.
• W4224883699 hasOpenAccess W4224883699 @default.
• W4224883699 hasPrimaryLocation W42248836991 @default.
• W4224883699 hasRelatedWork W2164421236 @default.

• next