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- W4224885904 abstract "Abstract Purpose: Bladder cancer represents 3% of all new cancer diagnoses per year. We propose intravesical radionuclide therapy using the β-emitter 90 Y linked to DOTA-biotin-avidin ([ 90 Y]DBA) to deliver short-range radiation against non-muscle invasive bladder cancer (NMIBC). Material and methods: Image-guided biodistribution of intravesical DBA was investigated in an animal model by radiolabeling DBA with the 68 Ga and dynamic microPET imaging following intravesical infusion of [ 68 Ga]DBA for up to 4 hours and post-necropsy γ-counting of organs. The antitumor activity of [ 90 Y]DBA was investigated using an orthotopic MB49 murine bladder cancer model. Mice were injected with luciferase-expressing MB49 cells and treated via intravesical administration with 9.2 MBq of [ 90 Y]DBA or unlabeled DBA 3 days after the tumor implantation. Bioluminescence imaging was conducted after tumor implantation to monitor the bladder tumor growth. In addition, we investigated the effects of [ 90 Y]DBA radiation on urothelial histology with immunohistochemistry analysis of bladder morphology. Results: Our results demonstrated that DBA is contained in the bladder for up to 4 hours after intravesical infusion. A single dose of [ 90 Y]DBA radiation treatment significantly reduced growth of MB49 bladder carcinoma. Attaching 90 Y to the DOTA-avidin prevents its re-absorption into the blood and distribution throughout the rest of the body. Furthermore, immunohistochemistry demonstrated that [ 90 Y]DBA radiation treatment did not irreversibly damage the bladder urothelium, which appeared similar to the normal urothelium of healthy mice. Conclusion: Our data demonstrates the potential of intravesical [ 90 Y]DBA as a treatment for non-muscle invasive bladder cancer." @default.
- W4224885904 created "2022-04-27" @default.
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- W4224885904 date "2022-04-26" @default.
- W4224885904 modified "2023-09-30" @default.
- W4224885904 title "Preliminary efficacy of [90Y] DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer" @default.
- W4224885904 doi "https://doi.org/10.21203/rs.3.rs-1559077/v1" @default.
- W4224885904 hasPublicationYear "2022" @default.
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