FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224911253> ?p ?o ?g. }

• W4224911253 endingPage "123418" @default.
• W4224911253 startingPage "123418" @default.
• W4224911253 abstract "Neurotransmitters (NTs) and their metabolites play crucial roles in the regulation of the sleep-wake cycle. Thus, a comprehensive quantitative analysis of NTs would be useful in elucidating the potential mechanisms involved in sedative-hypnotic activities. In this study, we developed a high-throughput quantitative method based on a two-dimensional chromatography-mass spectrometry technique to simultaneously analyze 63 NTs and their metabolites in rat plasma, brain homogenate, and microdialysis samples from five different sleep-associated regions of the brain. Moreover, this method was used to study the neurochemical mechanism of an adenosine analog sedative-hypnotic candidate YZG-331. Most of the correlations between NTs were lost after the administration of the sedative, particularly in the caudate putamen (CPu) and dorsal raphe nucleus (DRN), indicating that the sleep-wake balance was affected. Administration of the adenosine analog YZG-331 could act similar as accumulation of adenosine, inducing adenosine and its metabolite adenine were decreased significantly in the CPu, accompanying with GABA, aspartate, and glutamate changed slightly by the communications between different neurons to further promote sleep. In addition, YZG-331 affected the metabolism of tryptophan and serotonin (5-HT) in the DRN and orbital frontal cortex (OFC). Melatonin and 5-hydroxyindole-3-acetic acid (a metabolite of 5-HT) were significantly increased in the OFC, and the levels of glutamate/glutamine, asparagine, and adrenaline were altered. Sleep homeostasis is a balance between the duration of sleep and wakefulness and is coordinated by all NTs. The high-throughput quantitative method introduced in this study may aid in revealing the temporal cohesion among NTs, evaluating sleep homeostasis, and determining the effects of sedative-hypnotic drugs." @default.
• W4224911253 created "2022-04-27" @default.
• W4224911253 creator A5008117563 @default.
• W4224911253 creator A5020554528 @default.
• W4224911253 creator A5025095617 @default.
• W4224911253 creator A5027138684 @default.
• W4224911253 creator A5029272530 @default.
• W4224911253 creator A5053041939 @default.
• W4224911253 creator A5056424801 @default.
• W4224911253 creator A5063836497 @default.
• W4224911253 creator A5072622393 @default.
• W4224911253 date "2022-08-01" @default.
• W4224911253 modified "2023-09-27" @default.
• W4224911253 title "Comprehensive quantitative method for neurotransmitters to study the activity of a sedative-hypnotic candidate using microdialysis and LC×LC-MS/MS" @default.
• W4224911253 cites W1068002698 @default.
• W4224911253 cites W1929691281 @default.
• W4224911253 cites W1973886661 @default.
• W4224911253 cites W1975799678 @default.
• W4224911253 cites W1983320167 @default.
• W4224911253 cites W2003008250 @default.
• W4224911253 cites W2005292587 @default.
• W4224911253 cites W2034262374 @default.
• W4224911253 cites W2034342004 @default.
• W4224911253 cites W2034850943 @default.
• W4224911253 cites W2065083779 @default.
• W4224911253 cites W2065758078 @default.
• W4224911253 cites W2069480516 @default.
• W4224911253 cites W2083143366 @default.
• W4224911253 cites W2148102599 @default.
• W4224911253 cites W2164002789 @default.
• W4224911253 cites W2168487749 @default.
• W4224911253 cites W2461018869 @default.
• W4224911253 cites W2745147476 @default.
• W4224911253 cites W2773007283 @default.
• W4224911253 cites W2787267929 @default.
• W4224911253 cites W2807131364 @default.
• W4224911253 cites W2889133751 @default.
• W4224911253 cites W2891320392 @default.
• W4224911253 cites W2897933934 @default.
• W4224911253 cites W2942690889 @default.
• W4224911253 cites W2951830275 @default.
• W4224911253 doi "https://doi.org/10.1016/j.talanta.2022.123418" @default.
• W4224911253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35472683" @default.
• W4224911253 hasPublicationYear "2022" @default.
• W4224911253 type Work @default.
• W4224911253 citedByCount "3" @default.
• W4224911253 countsByYear W42249112532023 @default.
• W4224911253 crossrefType "journal-article" @default.
• W4224911253 hasAuthorship W4224911253A5008117563 @default.
• W4224911253 hasAuthorship W4224911253A5020554528 @default.
• W4224911253 hasAuthorship W4224911253A5025095617 @default.
• W4224911253 hasAuthorship W4224911253A5027138684 @default.
• W4224911253 hasAuthorship W4224911253A5029272530 @default.
• W4224911253 hasAuthorship W4224911253A5053041939 @default.
• W4224911253 hasAuthorship W4224911253A5056424801 @default.
• W4224911253 hasAuthorship W4224911253A5063836497 @default.
• W4224911253 hasAuthorship W4224911253A5072622393 @default.
• W4224911253 hasConcept C15744967 @default.
• W4224911253 hasConcept C169760540 @default.
• W4224911253 hasConcept C170493617 @default.
• W4224911253 hasConcept C185592680 @default.
• W4224911253 hasConcept C25876315 @default.
• W4224911253 hasConcept C2776991684 @default.
• W4224911253 hasConcept C2777477808 @default.
• W4224911253 hasConcept C2777602617 @default.
• W4224911253 hasConcept C2779320081 @default.
• W4224911253 hasConcept C2780930544 @default.
• W4224911253 hasConcept C28406088 @default.
• W4224911253 hasConcept C2910067630 @default.
• W4224911253 hasConcept C50156730 @default.
• W4224911253 hasConcept C522805319 @default.
• W4224911253 hasConcept C55493867 @default.
• W4224911253 hasConcept C61174792 @default.
• W4224911253 hasConcept C71924100 @default.
• W4224911253 hasConcept C98274493 @default.
• W4224911253 hasConceptScore W4224911253C15744967 @default.
• W4224911253 hasConceptScore W4224911253C169760540 @default.
• W4224911253 hasConceptScore W4224911253C170493617 @default.
• W4224911253 hasConceptScore W4224911253C185592680 @default.
• W4224911253 hasConceptScore W4224911253C25876315 @default.
• W4224911253 hasConceptScore W4224911253C2776991684 @default.
• W4224911253 hasConceptScore W4224911253C2777477808 @default.
• W4224911253 hasConceptScore W4224911253C2777602617 @default.
• W4224911253 hasConceptScore W4224911253C2779320081 @default.
• W4224911253 hasConceptScore W4224911253C2780930544 @default.
• W4224911253 hasConceptScore W4224911253C28406088 @default.
• W4224911253 hasConceptScore W4224911253C2910067630 @default.
• W4224911253 hasConceptScore W4224911253C50156730 @default.
• W4224911253 hasConceptScore W4224911253C522805319 @default.
• W4224911253 hasConceptScore W4224911253C55493867 @default.
• W4224911253 hasConceptScore W4224911253C61174792 @default.
• W4224911253 hasConceptScore W4224911253C71924100 @default.
• W4224911253 hasConceptScore W4224911253C98274493 @default.
• W4224911253 hasFunder F4320321001 @default.
• W4224911253 hasFunder F4320321849 @default.
• W4224911253 hasFunder F4320334977 @default.
• W4224911253 hasFunder F4320335777 @default.
• W4224911253 hasLocation W42249112531 @default.

• next