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• W4224918478 abstract "The metabolic environment in ischemic and hypoxic tumors is known to contribute to cancer progression. Importantly, peculiar metabolic changes occurring in malignant cells (the increased glycolysis and the hampered Krebs cycle) may contribute to decreased antioxidant-dependent defense in ischemic and hypoxic tumors.In the clinic, oxygen saturation of tumors is usually achieved by the application of water-soluble ozone and hyperbaric oxygen therapy. Tumor oxygenation has been shown to inhibit tumor growth and potentiate anti-tumor effects of chemoradiotherapy in animal experiments and the clinical setting. Tumor oxygenation could enhance anti-tumor effects achieved by tumor blood vessel occlusion or angiostatic therapy.Owing to a profound influence of ROS on both the innate and adaptive immunity, oxygen therapy, when combined simultaneously or sequentially with immunotherapeutic interventions (such as immune checkpoint inhibition, drug-induced immunostimulation, adoptive cell therapy, hyperthermia, etc.), could be considered as a novel highly-effective clinical biological approach to cancer treatment." @default.
• W4224918478 created "2022-04-28" @default.
• W4224918478 creator A5015773290 @default.
• W4224918478 creator A5034668335 @default.
• W4224918478 date "2022-04-29" @default.
• W4224918478 modified "2023-09-26" @default.
• W4224918478 title "Oxygen therapy in traditional and immunotherapeutic treatment protocols of cancer patients: current reality and future prospects" @default.
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• W4224918478 doi "https://doi.org/10.1080/14737140.2022.2070153" @default.
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