FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224920351> ?p ?o ?g. }

• W4224920351 endingPage "264" @default.
• W4224920351 startingPage "256" @default.
• W4224920351 abstract "Prolonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. Sevoflurane treatment significantly decreased the cell viability and induced apoptosis of SH-SY5Y cells. The expression level of Bcl-2 decreased, while that of Bax remarkably increased. Meanwhile, autophagy was activated by sevoflurane exposure as evidenced by increased expression levels of autophagy-related proteins (LC3-II and Atg5), decreased expression level of autophagic substrate P62, and increased autophagosomes and autolysosomes. Further autophagosomes and fewer autolysosomes were observed in the presence of Bafilomycin A1, an autolysosomes degradation inhibitor, suggesting that sevoflurane induced autophagic flux rather than inhibiting degradation of autophagy. Activation of autophagy by rapamycin partly reversed the sevoflurane-decreased cell viability. In contrast, inhibition of autophagy by 3-Methyladenine (3-MA) or Atg5-targeted small interfering RNA (siRNA) aggravated the sevoflurane-induced neurotoxicity. Further examination revealed that sevoflurane-induced autophagy was mediated by the AMPK/mTOR signaling pathway, with increased p-AMPK expression and decreased p-mTOR expression. Collectively, these results indicated that sevoflurane activates autophagy by regulating the AMPK/mTOR signaling pathway, which is protective against sevoflurane-induced damage in SH-SY5Y cells. Our results may assist clinicians to develop further promising therapeutic strategies for the neurotoxicity induced by inhaled anesthetics." @default.
• W4224920351 created "2022-04-28" @default.
• W4224920351 creator A5000901927 @default.
• W4224920351 creator A5021935553 @default.
• W4224920351 creator A5023067350 @default.
• W4224920351 creator A5041989421 @default.
• W4224920351 creator A5062674118 @default.
• W4224920351 creator A5076249770 @default.
• W4224920351 creator A5081165104 @default.
• W4224920351 creator A5088905478 @default.
• W4224920351 date "2022-05-01" @default.
• W4224920351 modified "2023-09-30" @default.
• W4224920351 title "4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway" @default.
• W4224920351 cites W1940612734 @default.
• W4224920351 cites W1965174412 @default.
• W4224920351 cites W2045139191 @default.
• W4224920351 cites W2059244111 @default.
• W4224920351 cites W2111031043 @default.
• W4224920351 cites W2159071814 @default.
• W4224920351 cites W2346911304 @default.
• W4224920351 cites W2584075583 @default.
• W4224920351 cites W2594669844 @default.
• W4224920351 cites W2625887862 @default.
• W4224920351 cites W2751007057 @default.
• W4224920351 cites W2751737102 @default.
• W4224920351 cites W2766860618 @default.
• W4224920351 cites W2778158425 @default.
• W4224920351 cites W2780186015 @default.
• W4224920351 cites W2793786377 @default.
• W4224920351 cites W2804881236 @default.
• W4224920351 cites W2896813617 @default.
• W4224920351 cites W2912932432 @default.
• W4224920351 cites W2924745135 @default.
• W4224920351 cites W2945887647 @default.
• W4224920351 cites W2980435746 @default.
• W4224920351 cites W2989893152 @default.
• W4224920351 cites W3003584293 @default.
• W4224920351 cites W3004011975 @default.
• W4224920351 cites W3029691457 @default.
• W4224920351 cites W3035839401 @default.
• W4224920351 cites W3060684972 @default.
• W4224920351 cites W3088237036 @default.
• W4224920351 cites W3089731071 @default.
• W4224920351 cites W3106899006 @default.
• W4224920351 cites W3110853227 @default.
• W4224920351 cites W3132685664 @default.
• W4224920351 cites W3174415462 @default.
• W4224920351 cites W3177731011 @default.
• W4224920351 cites W3184948025 @default.
• W4224920351 cites W3186849025 @default.
• W4224920351 cites W4233598183 @default.
• W4224920351 cites W69881358 @default.
• W4224920351 doi "https://doi.org/10.1016/j.neuro.2022.04.008" @default.
• W4224920351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35472370" @default.
• W4224920351 hasPublicationYear "2022" @default.
• W4224920351 type Work @default.
• W4224920351 citedByCount "0" @default.
• W4224920351 crossrefType "journal-article" @default.
• W4224920351 hasAuthorship W4224920351A5000901927 @default.
• W4224920351 hasAuthorship W4224920351A5021935553 @default.
• W4224920351 hasAuthorship W4224920351A5023067350 @default.
• W4224920351 hasAuthorship W4224920351A5041989421 @default.
• W4224920351 hasAuthorship W4224920351A5062674118 @default.
• W4224920351 hasAuthorship W4224920351A5076249770 @default.
• W4224920351 hasAuthorship W4224920351A5081165104 @default.
• W4224920351 hasAuthorship W4224920351A5088905478 @default.
• W4224920351 hasBestOaLocation W42249203511 @default.
• W4224920351 hasConcept C11960822 @default.
• W4224920351 hasConcept C178790620 @default.
• W4224920351 hasConcept C185592680 @default.
• W4224920351 hasConcept C190283241 @default.
• W4224920351 hasConcept C203522944 @default.
• W4224920351 hasConcept C2776715637 @default.
• W4224920351 hasConcept C2779083432 @default.
• W4224920351 hasConcept C2779491297 @default.
• W4224920351 hasConcept C2780124434 @default.
• W4224920351 hasConcept C2781000418 @default.
• W4224920351 hasConcept C2781453256 @default.
• W4224920351 hasConcept C29730261 @default.
• W4224920351 hasConcept C53227056 @default.
• W4224920351 hasConcept C54355233 @default.
• W4224920351 hasConcept C55493867 @default.
• W4224920351 hasConcept C62478195 @default.
• W4224920351 hasConcept C81885089 @default.
• W4224920351 hasConcept C86554907 @default.
• W4224920351 hasConcept C86803240 @default.
• W4224920351 hasConcept C95444343 @default.
• W4224920351 hasConcept C97029542 @default.
• W4224920351 hasConcept C98274493 @default.
• W4224920351 hasConceptScore W4224920351C11960822 @default.
• W4224920351 hasConceptScore W4224920351C178790620 @default.
• W4224920351 hasConceptScore W4224920351C185592680 @default.
• W4224920351 hasConceptScore W4224920351C190283241 @default.
• W4224920351 hasConceptScore W4224920351C203522944 @default.
• W4224920351 hasConceptScore W4224920351C2776715637 @default.
• W4224920351 hasConceptScore W4224920351C2779083432 @default.
• W4224920351 hasConceptScore W4224920351C2779491297 @default.
• W4224920351 hasConceptScore W4224920351C2780124434 @default.

• next