FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224925099> ?p ?o ?g. }

• W4224925099 abstract "Uniquely among mammalian organs, skin is capable of marked size change in adults, yet the mechanisms underlying this notable capacity are unclear. Here, we use a system of controlled tissue expansion in mice to uncover cellular and molecular determinants of skin growth. Through machine learning–guided three-dimensional tissue reconstruction, we capture morphometric changes in growing skin. We find that most growth is driven by the proliferation of the epidermis in response to mechanical tension, with more limited changes in dermal and subdermal compartments. Epidermal growth is achieved through preferential activation and differentiation of Lgr6 + stem cells of the epidermis, driven in part by the Hippo pathway. By single-cell RNA sequencing, we uncover further changes in mechanosensitive and metabolic pathways underlying growth control in the skin. These studies point to therapeutic strategies to enhance skin growth and establish a platform for understanding organ size dynamics in adult mammals." @default.
• W4224925099 created "2022-04-28" @default.
• W4224925099 creator A5000981486 @default.
• W4224925099 creator A5003835601 @default.
• W4224925099 creator A5010050586 @default.
• W4224925099 creator A5017348251 @default.
• W4224925099 creator A5017500080 @default.
• W4224925099 creator A5023048313 @default.
• W4224925099 creator A5026243099 @default.
• W4224925099 creator A5030621197 @default.
• W4224925099 creator A5031380690 @default.
• W4224925099 creator A5035980510 @default.
• W4224925099 creator A5037941681 @default.
• W4224925099 creator A5042261798 @default.
• W4224925099 creator A5042624994 @default.
• W4224925099 creator A5047017085 @default.
• W4224925099 creator A5058068721 @default.
• W4224925099 creator A5059076747 @default.
• W4224925099 creator A5063226324 @default.
• W4224925099 creator A5068246888 @default.
• W4224925099 creator A5081302323 @default.
• W4224925099 creator A5089980656 @default.
• W4224925099 date "2022-04-29" @default.
• W4224925099 modified "2023-10-14" @default.
• W4224925099 title "Mechanical tension mobilizes Lgr6 ⁺ epidermal stem cells to drive skin growth" @default.
• W4224925099 cites W1950305586 @default.
• W4224925099 cites W1964860185 @default.
• W4224925099 cites W1965157206 @default.
• W4224925099 cites W1985098236 @default.
• W4224925099 cites W1987012577 @default.
• W4224925099 cites W1995168386 @default.
• W4224925099 cites W2001775267 @default.
• W4224925099 cites W2010474967 @default.
• W4224925099 cites W2011202983 @default.
• W4224925099 cites W2021689495 @default.
• W4224925099 cites W2028593002 @default.
• W4224925099 cites W2057993832 @default.
• W4224925099 cites W2065678781 @default.
• W4224925099 cites W2069089843 @default.
• W4224925099 cites W2134405698 @default.
• W4224925099 cites W2139160260 @default.
• W4224925099 cites W2146337514 @default.
• W4224925099 cites W2146411094 @default.
• W4224925099 cites W2161092951 @default.
• W4224925099 cites W2166724005 @default.
• W4224925099 cites W2173159263 @default.
• W4224925099 cites W2174993055 @default.
• W4224925099 cites W2198052523 @default.
• W4224925099 cites W2201428971 @default.
• W4224925099 cites W2344013087 @default.
• W4224925099 cites W2489812534 @default.
• W4224925099 cites W2512544075 @default.
• W4224925099 cites W2531600570 @default.
• W4224925099 cites W2596650357 @default.
• W4224925099 cites W2603911205 @default.
• W4224925099 cites W2741205066 @default.
• W4224925099 cites W2743742472 @default.
• W4224925099 cites W2768054910 @default.
• W4224925099 cites W2773293509 @default.
• W4224925099 cites W2803147266 @default.
• W4224925099 cites W2893012998 @default.
• W4224925099 cites W2894486342 @default.
• W4224925099 cites W2896732826 @default.
• W4224925099 cites W2897926103 @default.
• W4224925099 cites W2898966044 @default.
• W4224925099 cites W2900981288 @default.
• W4224925099 cites W2902979549 @default.
• W4224925099 cites W2908828805 @default.
• W4224925099 cites W2925862067 @default.
• W4224925099 cites W2944545583 @default.
• W4224925099 cites W2945205721 @default.
• W4224925099 cites W2951799803 @default.
• W4224925099 cites W2954258372 @default.
• W4224925099 cites W2969022049 @default.
• W4224925099 cites W2979342572 @default.
• W4224925099 cites W3007680205 @default.
• W4224925099 cites W3011263601 @default.
• W4224925099 cites W3014624627 @default.
• W4224925099 cites W3036513507 @default.
• W4224925099 cites W3046219647 @default.
• W4224925099 cites W3090928815 @default.
• W4224925099 cites W3093055964 @default.
• W4224925099 cites W3107102241 @default.
• W4224925099 cites W3111423020 @default.
• W4224925099 cites W3120345372 @default.
• W4224925099 cites W3142660110 @default.
• W4224925099 cites W3169727401 @default.
• W4224925099 cites W3173983612 @default.
• W4224925099 cites W4361868711 @default.
• W4224925099 cites W630914453 @default.
• W4224925099 doi "https://doi.org/10.1126/sciadv.abl8698" @default.
• W4224925099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35476447" @default.
• W4224925099 hasPublicationYear "2022" @default.
• W4224925099 type Work @default.
• W4224925099 citedByCount "6" @default.
• W4224925099 countsByYear W42249250992022 @default.
• W4224925099 countsByYear W42249250992023 @default.
• W4224925099 crossrefType "journal-article" @default.
• W4224925099 hasAuthorship W4224925099A5000981486 @default.
• W4224925099 hasAuthorship W4224925099A5003835601 @default.

• next