FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224939580> ?p ?o ?g. }

• W4224939580 endingPage "3275" @default.
• W4224939580 startingPage "3267" @default.
• W4224939580 abstract "From the petroleum ether and ethyl acetate portions of the 95% ethanol extract of Ficus tikoua Bur., a new hemiacetal chromone racemate, named (±)-ficunomone (1), together with twenty-two known flavonoids (2-23) were isolated. The new structure was elucidated by NMR, HRESIMS, and X-ray single-crystal diffraction analysis, and the known structures were determined by comparison of spectroscopic data with those reported from literatures. All the compounds were assayed for their inhibitory activities against yeast α-glucosidase, seven flavonoids could inhibit α-glucosidase, among which compounds 22 and 23 exhibited the highest inhibitory activity, with IC50 values at 5.12 ± 0.10 and 3.43 ± 0.15 μM respectively. Preliminary structure and relationship activity of all the compounds was analysed. Kinetic analysis of compounds 22 and 23 indicated that they are both uncompetitive inhibitors. Molecular docking studies revealed that they bound to amino acid residues of the α-glucosidase activity pocket." @default.
• W4224939580 created "2022-04-28" @default.
• W4224939580 creator A5001590293 @default.
• W4224939580 creator A5002366018 @default.
• W4224939580 creator A5032141487 @default.
• W4224939580 creator A5040336756 @default.
• W4224939580 creator A5057529151 @default.
• W4224939580 creator A5057962163 @default.
• W4224939580 date "2022-04-25" @default.
• W4224939580 modified "2023-10-16" @default.
• W4224939580 title "A new hemiacetal chromone racemate and α-glucosidase inhibitors from <i>Ficus tikoua</i> Bur" @default.
• W4224939580 cites W1555410946 @default.
• W4224939580 cites W1970056741 @default.
• W4224939580 cites W1970574300 @default.
• W4224939580 cites W1981862903 @default.
• W4224939580 cites W1983560998 @default.
• W4224939580 cites W1995629734 @default.
• W4224939580 cites W1997764354 @default.
• W4224939580 cites W2010630505 @default.
• W4224939580 cites W2021170416 @default.
• W4224939580 cites W2021917381 @default.
• W4224939580 cites W2024401279 @default.
• W4224939580 cites W2034061678 @default.
• W4224939580 cites W2050723215 @default.
• W4224939580 cites W2051361222 @default.
• W4224939580 cites W2053990084 @default.
• W4224939580 cites W2061597978 @default.
• W4224939580 cites W2070439908 @default.
• W4224939580 cites W2085777986 @default.
• W4224939580 cites W2086157884 @default.
• W4224939580 cites W2108580921 @default.
• W4224939580 cites W2112991946 @default.
• W4224939580 cites W2120023438 @default.
• W4224939580 cites W2167401131 @default.
• W4224939580 cites W2321626598 @default.
• W4224939580 cites W2407685788 @default.
• W4224939580 cites W2605700114 @default.
• W4224939580 cites W2884023520 @default.
• W4224939580 cites W2953569983 @default.
• W4224939580 cites W3010635462 @default.
• W4224939580 cites W4210570232 @default.
• W4224939580 doi "https://doi.org/10.1080/14786419.2022.2068544" @default.
• W4224939580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35469532" @default.
• W4224939580 hasPublicationYear "2022" @default.
• W4224939580 type Work @default.
• W4224939580 citedByCount "4" @default.
• W4224939580 countsByYear W42249395802022 @default.
• W4224939580 countsByYear W42249395802023 @default.
• W4224939580 crossrefType "journal-article" @default.
• W4224939580 hasAuthorship W4224939580A5001590293 @default.
• W4224939580 hasAuthorship W4224939580A5002366018 @default.
• W4224939580 hasAuthorship W4224939580A5032141487 @default.
• W4224939580 hasAuthorship W4224939580A5040336756 @default.
• W4224939580 hasAuthorship W4224939580A5057529151 @default.
• W4224939580 hasAuthorship W4224939580A5057962163 @default.
• W4224939580 hasBestOaLocation W42249395802 @default.
• W4224939580 hasConcept C159110408 @default.
• W4224939580 hasConcept C178790620 @default.
• W4224939580 hasConcept C185592680 @default.
• W4224939580 hasConcept C19549132 @default.
• W4224939580 hasConcept C2776148806 @default.
• W4224939580 hasConcept C2776572972 @default.
• W4224939580 hasConcept C2779326954 @default.
• W4224939580 hasConcept C2779858419 @default.
• W4224939580 hasConcept C2780161600 @default.
• W4224939580 hasConcept C2780407432 @default.
• W4224939580 hasConcept C41685203 @default.
• W4224939580 hasConcept C4725764 @default.
• W4224939580 hasConcept C71240020 @default.
• W4224939580 hasConcept C71924100 @default.
• W4224939580 hasConceptScore W4224939580C159110408 @default.
• W4224939580 hasConceptScore W4224939580C178790620 @default.
• W4224939580 hasConceptScore W4224939580C185592680 @default.
• W4224939580 hasConceptScore W4224939580C19549132 @default.
• W4224939580 hasConceptScore W4224939580C2776148806 @default.
• W4224939580 hasConceptScore W4224939580C2776572972 @default.
• W4224939580 hasConceptScore W4224939580C2779326954 @default.
• W4224939580 hasConceptScore W4224939580C2779858419 @default.
• W4224939580 hasConceptScore W4224939580C2780161600 @default.
• W4224939580 hasConceptScore W4224939580C2780407432 @default.
• W4224939580 hasConceptScore W4224939580C41685203 @default.
• W4224939580 hasConceptScore W4224939580C4725764 @default.
• W4224939580 hasConceptScore W4224939580C71240020 @default.
• W4224939580 hasConceptScore W4224939580C71924100 @default.
• W4224939580 hasFunder F4320321001 @default.
• W4224939580 hasIssue "19" @default.
• W4224939580 hasLocation W42249395801 @default.
• W4224939580 hasLocation W42249395802 @default.
• W4224939580 hasLocation W42249395803 @default.
• W4224939580 hasOpenAccess W4224939580 @default.
• W4224939580 hasPrimaryLocation W42249395801 @default.
• W4224939580 hasRelatedWork W2105744842 @default.
• W4224939580 hasRelatedWork W2352153516 @default.
• W4224939580 hasRelatedWork W2353817397 @default.
• W4224939580 hasRelatedWork W2357039630 @default.
• W4224939580 hasRelatedWork W2357146253 @default.
• W4224939580 hasRelatedWork W2372782691 @default.
• W4224939580 hasRelatedWork W2379387056 @default.

• next