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- W4224950010 abstract "Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Furthermore, its metabolites (e.g., IAA, Indole, 5-HT) enhanced hepatic glycolipid metabolism and down-regulated intestinal oxidative stress by improving the brain hormone release. Tryptophan metabolites and bile acids also promoted liver lipid metabolism and inhibited intestinal inflammation (MyD88/NF-κB) via the enterohepatic circulation. Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis." @default.
- W4224950010 created "2022-04-28" @default.
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- W4224950010 date "2022-04-27" @default.
- W4224950010 modified "2023-09-29" @default.
- W4224950010 title "Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism" @default.
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- W4224950010 doi "https://doi.org/10.1021/acs.jafc.2c01883" @default.
- W4224950010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35475616" @default.
- W4224950010 hasPublicationYear "2022" @default.