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- W4224951364 abstract "We have recently described a novel family of compounds of reduced size and dual anti-HIV and anti-EV71 activity that encompasses tripodal and tetrapodal derivatives. The tripodal prototype, AL-470, has a nitro group at the focal point of the central scaffold and three attached tryptophan residues, each of which bearing an isophthaloyl moiety at the C2 position of the indole ring. A nitro to amino substitution has allowed us now to introduce a chemically addressable functionality to perform further structural modifications consisting of both direct and linker-mediated attachment of several aromatic groups, including the fluorescent dye Alexa Fluor 647 and the antibody-recruiting 2,4-dinitrophenyl motif. Some of the derivatives turned out to be more potent and selective than AL-470 against HIV-1, HIV-2 and EV-A71. The fluorescent probe demonstrated a specific tropism for intestines and lungs, two important niches for the human microbiome in health and disease." @default.
- W4224951364 created "2022-04-28" @default.
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- W4224951364 date "2022-07-01" @default.
- W4224951364 modified "2023-10-14" @default.
- W4224951364 title "Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors" @default.
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- W4224951364 doi "https://doi.org/10.1016/j.ejmech.2022.114414" @default.
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