Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224952085> ?p ?o ?g. }
- W4224952085 endingPage "941" @default.
- W4224952085 startingPage "941" @default.
- W4224952085 abstract "The incidence of type I diabetes has been increasing worldwide at an annual rate of approximately 3%. One of the strategies to treat type I diabetes is islet transplantation, in which damaged β-cells are replaced with new islets. To improve β-cells' expansion and pseudoislet formation, studies are focusing on using extracellular-matrix-resembling substrates. We evaluated the potential of salmon fibrinogen and chitosan electrospun scaffold as cell substrate for cultivating MIN-6 cells. The morphology of cells, insulin secretion and gene expression was evaluated and compared with other substrates (nanofibrous scaffold, microporous scaffold and tissue culture polystyrene). We found that all tested 3D conditions favored the pseudoislet formation of MIN-6 cells. The insulin secretion of MIN-6 cells after stimulation with high-glucose media shows approximately a 9-fold increase compared to the control group when a fibrinogen/chitosan-based electrospun scaffold was used for cultivation. The differences in insulin secretion were corroborated by differences in gene expression. The differences in insulin secretion could probably be attributed to the differences in the mechanical and/or chemical nature of the tested substrates." @default.
- W4224952085 created "2022-04-28" @default.
- W4224952085 creator A5013347814 @default.
- W4224952085 creator A5071917727 @default.
- W4224952085 creator A5084952890 @default.
- W4224952085 date "2022-04-26" @default.
- W4224952085 modified "2023-10-14" @default.
- W4224952085 title "Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion" @default.
- W4224952085 cites W1982548016 @default.
- W4224952085 cites W2000917871 @default.
- W4224952085 cites W2015640138 @default.
- W4224952085 cites W2025522134 @default.
- W4224952085 cites W2052964822 @default.
- W4224952085 cites W2057005917 @default.
- W4224952085 cites W2063202883 @default.
- W4224952085 cites W2063689163 @default.
- W4224952085 cites W2065847096 @default.
- W4224952085 cites W2070985778 @default.
- W4224952085 cites W2078320655 @default.
- W4224952085 cites W2084056352 @default.
- W4224952085 cites W2086232800 @default.
- W4224952085 cites W2099399967 @default.
- W4224952085 cites W2110649772 @default.
- W4224952085 cites W2119199959 @default.
- W4224952085 cites W2138386311 @default.
- W4224952085 cites W2167279371 @default.
- W4224952085 cites W2228603639 @default.
- W4224952085 cites W2313862609 @default.
- W4224952085 cites W2335692117 @default.
- W4224952085 cites W2338389166 @default.
- W4224952085 cites W2549169970 @default.
- W4224952085 cites W2773887742 @default.
- W4224952085 cites W2794133892 @default.
- W4224952085 cites W2885582644 @default.
- W4224952085 cites W2903165427 @default.
- W4224952085 cites W2903991851 @default.
- W4224952085 cites W2932384472 @default.
- W4224952085 cites W2942012895 @default.
- W4224952085 cites W2997825486 @default.
- W4224952085 cites W3083235639 @default.
- W4224952085 cites W3093587048 @default.
- W4224952085 cites W3108793167 @default.
- W4224952085 cites W3122259580 @default.
- W4224952085 cites W3126646935 @default.
- W4224952085 cites W3164867265 @default.
- W4224952085 cites W3211246923 @default.
- W4224952085 doi "https://doi.org/10.3390/pharmaceutics14050941" @default.
- W4224952085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35631527" @default.
- W4224952085 hasPublicationYear "2022" @default.
- W4224952085 type Work @default.
- W4224952085 citedByCount "1" @default.
- W4224952085 countsByYear W42249520852023 @default.
- W4224952085 crossrefType "journal-article" @default.
- W4224952085 hasAuthorship W4224952085A5013347814 @default.
- W4224952085 hasAuthorship W4224952085A5071917727 @default.
- W4224952085 hasAuthorship W4224952085A5084952890 @default.
- W4224952085 hasBestOaLocation W42249520851 @default.
- W4224952085 hasConcept C126322002 @default.
- W4224952085 hasConcept C134018914 @default.
- W4224952085 hasConcept C136229726 @default.
- W4224952085 hasConcept C165220095 @default.
- W4224952085 hasConcept C185592680 @default.
- W4224952085 hasConcept C189165786 @default.
- W4224952085 hasConcept C2779036427 @default.
- W4224952085 hasConcept C2779306644 @default.
- W4224952085 hasConcept C2911091166 @default.
- W4224952085 hasConcept C49039625 @default.
- W4224952085 hasConcept C55493867 @default.
- W4224952085 hasConcept C71924100 @default.
- W4224952085 hasConcept C86803240 @default.
- W4224952085 hasConcept C89429830 @default.
- W4224952085 hasConcept C95444343 @default.
- W4224952085 hasConceptScore W4224952085C126322002 @default.
- W4224952085 hasConceptScore W4224952085C134018914 @default.
- W4224952085 hasConceptScore W4224952085C136229726 @default.
- W4224952085 hasConceptScore W4224952085C165220095 @default.
- W4224952085 hasConceptScore W4224952085C185592680 @default.
- W4224952085 hasConceptScore W4224952085C189165786 @default.
- W4224952085 hasConceptScore W4224952085C2779036427 @default.
- W4224952085 hasConceptScore W4224952085C2779306644 @default.
- W4224952085 hasConceptScore W4224952085C2911091166 @default.
- W4224952085 hasConceptScore W4224952085C49039625 @default.
- W4224952085 hasConceptScore W4224952085C55493867 @default.
- W4224952085 hasConceptScore W4224952085C71924100 @default.
- W4224952085 hasConceptScore W4224952085C86803240 @default.
- W4224952085 hasConceptScore W4224952085C89429830 @default.
- W4224952085 hasConceptScore W4224952085C95444343 @default.
- W4224952085 hasFunder F4320321090 @default.
- W4224952085 hasIssue "5" @default.
- W4224952085 hasLocation W42249520851 @default.
- W4224952085 hasLocation W42249520852 @default.
- W4224952085 hasLocation W42249520853 @default.
- W4224952085 hasLocation W42249520854 @default.
- W4224952085 hasOpenAccess W4224952085 @default.
- W4224952085 hasPrimaryLocation W42249520851 @default.
- W4224952085 hasRelatedWork W1973049774 @default.
- W4224952085 hasRelatedWork W1985965417 @default.
- W4224952085 hasRelatedWork W1986775667 @default.