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- W4224957060 abstract "In the last decade, relevant biotechnology advances took place in the biofabrication of craniofacial exocrine gland organoids mimicking lacrimal and salivary glands. Though certain challenges still remain not only due to the lack of protocols for organoid reproducibility but also towards the scarcity of methodologies for creating preclinical disease models with aging multi-omic signatures. Previously, our research group successful developed three-dimensional (3D) bioassembly technologies towards the generation of functional epithelial gland-like organoids via magnetic 3D bioprinting platforms (M3DB). To meet the needs of our aging Asian societies, a next step was taken to design consistent M3DB protocols for bioengineering organoid models with aging molecular and pathological features for lacrimal glands (LG) and salivary glands (SG). Herein, we established a feasible step-by-step protocol for producing both LG and SG organoids using M3DB platforms. Such a protocol provided reproducible preliminary outcomes resembling LG/SG organoids. Both acinar and ductal epithelial compartments were prominent (21 4.32% versus 426.72% of total cells, respectively), and could be clearly identified in these organoids. Meanwhile, these can be further developed into aging signature models by inducing cellular senescence via chemical mutagenesis. The generation of senescence-like organoids is our ultimate milestone aiming towards high throughput applications for drug screening and discovery and gene therapy investigations to reverse aging." @default.
- W4224957060 created "2022-04-28" @default.
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- W4224957060 date "2022-03-02" @default.
- W4224957060 modified "2023-10-16" @default.
- W4224957060 title "Establishment of craniofacial exocrine gland organoid magnetic bioassembly platforms as aging multi-omic signatures v1" @default.
- W4224957060 doi "https://doi.org/10.17504/protocols.io.b5ttq6nn" @default.
- W4224957060 hasPublicationYear "2022" @default.
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