Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224987934> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4224987934 endingPage "137" @default.
- W4224987934 startingPage "131" @default.
- W4224987934 abstract "Frequency of PD-L1 expression and the role of immunotherapy in malignant peritoneal mesothelioma (MPM) have not been well characterized. The purpose of this study was to determine PD-L1 expression in patients with MPM and perform an exploratory analysis for associations between PD-L1 and its biological behavior in MPM.Tumor samples were collected from patients undergoing surgical interventions between January 2018 and June 2020. Specimens were stained with anti-PD-L1 antibodies (Dako 22c3) and positivity was determined by tumor proportion score (TPS) or combined positive score (CPS) being ≥1%.Twenty one samples were obtained from 21 patients. Sixteen of 21 (76%) samples were CPS positive and 9 of 21 (43%) were TPS positive. Three samples had more aggressive biphasic/sarcomatoid histology and a high CPS and TPS (CPS: 3, 75, 95%; TPS: 2, 60, 90%). On an exploratory analysis, as the CPS or TPS threshold increased, there was a trend towards worse survival.MPM has a high frequency of PD-L1 expression, which may be associated with more aggressive tumor biology. These data provide the foundation for continued evaluation of checkpoint inhibition in patients with MPM." @default.
- W4224987934 created "2022-04-28" @default.
- W4224987934 creator A5002512959 @default.
- W4224987934 creator A5009692912 @default.
- W4224987934 creator A5031509385 @default.
- W4224987934 creator A5039831151 @default.
- W4224987934 creator A5055233222 @default.
- W4224987934 creator A5058025282 @default.
- W4224987934 creator A5059231210 @default.
- W4224987934 creator A5068717118 @default.
- W4224987934 creator A5081233015 @default.
- W4224987934 creator A5087018669 @default.
- W4224987934 date "2022-09-01" @default.
- W4224987934 modified "2023-10-06" @default.
- W4224987934 title "Expression of PD-L1 in Patients With Malignant Peritoneal Mesothelioma: A Pilot Study" @default.
- W4224987934 cites W2036311740 @default.
- W4224987934 cites W2291531085 @default.
- W4224987934 cites W2510679674 @default.
- W4224987934 cites W2614782680 @default.
- W4224987934 cites W2776272710 @default.
- W4224987934 cites W2801062708 @default.
- W4224987934 cites W2891886598 @default.
- W4224987934 cites W2907561635 @default.
- W4224987934 cites W2916532294 @default.
- W4224987934 cites W2924341172 @default.
- W4224987934 cites W2945057866 @default.
- W4224987934 cites W2945877477 @default.
- W4224987934 cites W2965455693 @default.
- W4224987934 cites W3094452968 @default.
- W4224987934 cites W3096715224 @default.
- W4224987934 cites W3111997026 @default.
- W4224987934 cites W3132958914 @default.
- W4224987934 cites W3151500837 @default.
- W4224987934 doi "https://doi.org/10.1016/j.jss.2022.04.005" @default.
- W4224987934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35489218" @default.
- W4224987934 hasPublicationYear "2022" @default.
- W4224987934 type Work @default.
- W4224987934 citedByCount "3" @default.
- W4224987934 countsByYear W42249879342023 @default.
- W4224987934 crossrefType "journal-article" @default.
- W4224987934 hasAuthorship W4224987934A5002512959 @default.
- W4224987934 hasAuthorship W4224987934A5009692912 @default.
- W4224987934 hasAuthorship W4224987934A5031509385 @default.
- W4224987934 hasAuthorship W4224987934A5039831151 @default.
- W4224987934 hasAuthorship W4224987934A5055233222 @default.
- W4224987934 hasAuthorship W4224987934A5058025282 @default.
- W4224987934 hasAuthorship W4224987934A5059231210 @default.
- W4224987934 hasAuthorship W4224987934A5068717118 @default.
- W4224987934 hasAuthorship W4224987934A5081233015 @default.
- W4224987934 hasAuthorship W4224987934A5087018669 @default.
- W4224987934 hasConcept C121608353 @default.
- W4224987934 hasConcept C126322002 @default.
- W4224987934 hasConcept C142724271 @default.
- W4224987934 hasConcept C143998085 @default.
- W4224987934 hasConcept C204232928 @default.
- W4224987934 hasConcept C2777407522 @default.
- W4224987934 hasConcept C2777701055 @default.
- W4224987934 hasConcept C2778995398 @default.
- W4224987934 hasConcept C57742111 @default.
- W4224987934 hasConcept C71924100 @default.
- W4224987934 hasConceptScore W4224987934C121608353 @default.
- W4224987934 hasConceptScore W4224987934C126322002 @default.
- W4224987934 hasConceptScore W4224987934C142724271 @default.
- W4224987934 hasConceptScore W4224987934C143998085 @default.
- W4224987934 hasConceptScore W4224987934C204232928 @default.
- W4224987934 hasConceptScore W4224987934C2777407522 @default.
- W4224987934 hasConceptScore W4224987934C2777701055 @default.
- W4224987934 hasConceptScore W4224987934C2778995398 @default.
- W4224987934 hasConceptScore W4224987934C57742111 @default.
- W4224987934 hasConceptScore W4224987934C71924100 @default.
- W4224987934 hasLocation W42249879341 @default.
- W4224987934 hasLocation W42249879342 @default.
- W4224987934 hasOpenAccess W4224987934 @default.
- W4224987934 hasPrimaryLocation W42249879341 @default.
- W4224987934 hasRelatedWork W2037309347 @default.
- W4224987934 hasRelatedWork W2065943406 @default.
- W4224987934 hasRelatedWork W2072140828 @default.
- W4224987934 hasRelatedWork W2081773521 @default.
- W4224987934 hasRelatedWork W2158397009 @default.
- W4224987934 hasRelatedWork W2268939928 @default.
- W4224987934 hasRelatedWork W2408693058 @default.
- W4224987934 hasRelatedWork W2465982491 @default.
- W4224987934 hasRelatedWork W3164795457 @default.
- W4224987934 hasRelatedWork W76322367 @default.
- W4224987934 hasVolume "277" @default.
- W4224987934 isParatext "false" @default.
- W4224987934 isRetracted "false" @default.
- W4224987934 workType "article" @default.