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- W4224991305 endingPage "151277" @default.
- W4224991305 startingPage "151277" @default.
- W4224991305 abstract "Bone metastases are of high clinical relevance because they are a frequent complication of most types of common cancers, such as breast and prostate. The metastatic process is complex, requiring the completion of several different steps to allow successful dissemination and homing. In addition, preparation of the metastatic niche changes the constant cycle of bone matrix formation and degradation, leading to the clinical phenotypes of lytic and sclerotic lesions. We review our current knowledge on this topic and briefly explain the current treatment landscape of bone metastasis.These include PubMed, international guidelines, and clinician experience.Bone metastases remain a clinical challenge that negatively impacts patients prognosis and quality of life. A comprehensive understanding of the complex molecular mechanisms that results in bone metastasis is the basis for successful treatment of affected patients. The disruption of bone matrix metabolism is already recognized as the prerequisite for metastasis formation, but many open questions remain that need to be addressed in future research to establish individually tailored treatment approaches.Patient-centered therapy of bone metastases requires suitable pharmacological options, and importantly a holistic approach in care delivery across the multidisciplinary team. Nurses provide the cornerstone of the multidisciplinary team and provide the closest and the most frequent contact to the patient and their families to provide timely intervention. Nurses require a basic understanding of the complex physiology of metastasis to inform practice." @default.
- W4224991305 created "2022-04-28" @default.
- W4224991305 creator A5000820032 @default.
- W4224991305 creator A5004035127 @default.
- W4224991305 creator A5067767629 @default.
- W4224991305 date "2022-04-01" @default.
- W4224991305 modified "2023-09-24" @default.
- W4224991305 title "Bone Metastases: From Mechanisms to Treatment" @default.
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- W4224991305 doi "https://doi.org/10.1016/j.soncn.2022.151277" @default.
- W4224991305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35474145" @default.
- W4224991305 hasPublicationYear "2022" @default.
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