Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224992004> ?p ?o ?g. }
- W4224992004 endingPage "4847" @default.
- W4224992004 startingPage "4847" @default.
- W4224992004 abstract "Migraine is a common brain-disorder that affects 15% of the population. Converging evidence shows that migraine is associated with gastrointestinal disorders. However, the mechanisms underlying the interaction between the gut and brain in patients with migraine are not clear. In this study, we evaluated the role of the short-chain fatty acids (SCFAs) as sodium propionate (SP) and sodium butyrate (SB) on microbiota profile and intestinal permeability in a mouse model of migraine induced by nitroglycerine (NTG). The mice were orally administered SB and SP at the dose of 10, 30 and 100 mg/kg, 5 min after NTG intraperitoneal injections. Behavioral tests were used to evaluate migraine-like pain. Histological and molecular analyses were performed on the intestine. The composition of the intestinal microbiota was extracted from frozen fecal samples and sequenced with an Illumina MiSeq System. Our results demonstrated that the SP and SB treatments attenuated hyperalgesia and pain following NTG injection. Moreover, SP and SB reduced histological damage in the intestine and restored intestinal permeability and the intestinal microbiota profile. These results provide corroborating evidence that SB and SP exert a protective effect on central sensitization induced by NTG through a modulation of intestinal microbiota, suggesting the potential application of SCFAs as novel supportive therapies for intestinal disfunction associated with migraine." @default.
- W4224992004 created "2022-04-28" @default.
- W4224992004 creator A5007489715 @default.
- W4224992004 creator A5012341521 @default.
- W4224992004 creator A5028276792 @default.
- W4224992004 creator A5042097092 @default.
- W4224992004 creator A5048364314 @default.
- W4224992004 creator A5063288145 @default.
- W4224992004 creator A5065961339 @default.
- W4224992004 creator A5073045089 @default.
- W4224992004 creator A5076323717 @default.
- W4224992004 date "2022-04-27" @default.
- W4224992004 modified "2023-09-25" @default.
- W4224992004 title "Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine" @default.
- W4224992004 cites W1495556587 @default.
- W4224992004 cites W1663623302 @default.
- W4224992004 cites W1963591991 @default.
- W4224992004 cites W1965790846 @default.
- W4224992004 cites W1992152055 @default.
- W4224992004 cites W2002281336 @default.
- W4224992004 cites W2020182885 @default.
- W4224992004 cites W2020272944 @default.
- W4224992004 cites W2025819729 @default.
- W4224992004 cites W2047455969 @default.
- W4224992004 cites W2052258972 @default.
- W4224992004 cites W2080602987 @default.
- W4224992004 cites W2104769611 @default.
- W4224992004 cites W2127743008 @default.
- W4224992004 cites W2128711701 @default.
- W4224992004 cites W2131271579 @default.
- W4224992004 cites W2188892106 @default.
- W4224992004 cites W2472180307 @default.
- W4224992004 cites W2516916387 @default.
- W4224992004 cites W2526966274 @default.
- W4224992004 cites W2527872371 @default.
- W4224992004 cites W2560974854 @default.
- W4224992004 cites W2612857033 @default.
- W4224992004 cites W2616825195 @default.
- W4224992004 cites W2619149875 @default.
- W4224992004 cites W2752512915 @default.
- W4224992004 cites W2807423072 @default.
- W4224992004 cites W2807772034 @default.
- W4224992004 cites W2890428981 @default.
- W4224992004 cites W2912498165 @default.
- W4224992004 cites W2921966151 @default.
- W4224992004 cites W2946372752 @default.
- W4224992004 cites W2956280647 @default.
- W4224992004 cites W2990618091 @default.
- W4224992004 cites W3003690367 @default.
- W4224992004 cites W3003912482 @default.
- W4224992004 cites W3004327143 @default.
- W4224992004 cites W3006647806 @default.
- W4224992004 cites W3011444375 @default.
- W4224992004 cites W3015407380 @default.
- W4224992004 cites W3045892068 @default.
- W4224992004 cites W3049637905 @default.
- W4224992004 cites W3080830493 @default.
- W4224992004 cites W3093256017 @default.
- W4224992004 cites W3094514903 @default.
- W4224992004 cites W3118680660 @default.
- W4224992004 cites W3155693531 @default.
- W4224992004 cites W3193421084 @default.
- W4224992004 cites W3207836534 @default.
- W4224992004 cites W3211236278 @default.
- W4224992004 cites W3211779138 @default.
- W4224992004 cites W3217169543 @default.
- W4224992004 cites W637138851 @default.
- W4224992004 cites W94215450 @default.
- W4224992004 doi "https://doi.org/10.3390/ijms23094847" @default.
- W4224992004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35563235" @default.
- W4224992004 hasPublicationYear "2022" @default.
- W4224992004 type Work @default.
- W4224992004 citedByCount "3" @default.
- W4224992004 countsByYear W42249920042022 @default.
- W4224992004 countsByYear W42249920042023 @default.
- W4224992004 crossrefType "journal-article" @default.
- W4224992004 hasAuthorship W4224992004A5007489715 @default.
- W4224992004 hasAuthorship W4224992004A5012341521 @default.
- W4224992004 hasAuthorship W4224992004A5028276792 @default.
- W4224992004 hasAuthorship W4224992004A5042097092 @default.
- W4224992004 hasAuthorship W4224992004A5048364314 @default.
- W4224992004 hasAuthorship W4224992004A5063288145 @default.
- W4224992004 hasAuthorship W4224992004A5065961339 @default.
- W4224992004 hasAuthorship W4224992004A5073045089 @default.
- W4224992004 hasAuthorship W4224992004A5076323717 @default.
- W4224992004 hasBestOaLocation W42249920041 @default.
- W4224992004 hasConcept C104317684 @default.
- W4224992004 hasConcept C126322002 @default.
- W4224992004 hasConcept C15490471 @default.
- W4224992004 hasConcept C170493617 @default.
- W4224992004 hasConcept C185592680 @default.
- W4224992004 hasConcept C203014093 @default.
- W4224992004 hasConcept C2778541695 @default.
- W4224992004 hasConcept C2778942008 @default.
- W4224992004 hasConcept C2779245659 @default.
- W4224992004 hasConcept C2781071285 @default.
- W4224992004 hasConcept C2908647359 @default.
- W4224992004 hasConcept C42219234 @default.