FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224993370> ?p ?o ?g. }

• W4224993370 endingPage "1813" @default.
• W4224993370 startingPage "1798" @default.
• W4224993370 abstract "The occurrence and development of acute liver failure (ALF) is closely related to a series of inflammatory reactions, such as the production of reactive oxygen species (ROS). Hypoxia inducible factor 1α (HIF-1α) is a key factor that regulates oxygen homeostasis and redox, and the stability of HIF-1α is related to the ROS level regulated by Sirtuin (Sirt) family. The activation of Sirt1 will lead to a powerful antioxidant defense system and therapeutic effects in liver disease. However, little is known about the relationship between HIF-1α and Sirt1 in the process of ALF and the molecular mechanism.To investigate whether HIF-1α may be a target of Sirt1 deacetylation and what the effects on ALF are.Mice were administrated lipopolysaccharide (LPS)/D-gal and exposed to hypoxic conditions as animal model, and resveratrol was used as an activator of Sirt1. The cellular model was established with L02 cells stimulated by LPS. N-acetyl-L-cysteine was used to remove ROS, and the expression of Sirt1 was inhibited by nicotinamide. Western blotting was used to detect Sirt1 and HIF-1α activity and related protein expression. The possible signaling pathways involved were analyzed by immunofluorescent staining, co-immunoprecipitation, dihydroethidium staining, and Western blotting.Compared with mice stimulated with LPS alone, the expression of Sirt1 decreased, the level of HIF-1α acetylation increased in hypoxic mice, and the levels of carbonic anhydrase 9 and Bcl-2-adenovirus E1B interacting protein 3 increased significantly, which was regulated by HIF-1α, indicating an increase of HIF-1α activity. Under hypoxia, the down-regulation of Sirt1 activated and acetylated HIF-1α in L02 cells. The inhibition of Sirt1 significantly aggravated this effect and the massive production of ROS. The regulation of ROS was partly through peroxisome proliferator-activated receptor alpha or AMP-activated protein kinase. Resveratrol, a Sirt1 activator, effectively relieved ALF aggravated by hypoxia, the production of ROS, and cell apoptosis. It also induced the deacetylation of HIF-1α and inhibited the activity of HIF-1α.Sirt1 may have a protective effect on ALF by inducing HIF-1α deacetylation to reduce ROS." @default.
• W4224993370 created "2022-04-28" @default.
• W4224993370 creator A5032088677 @default.
• W4224993370 creator A5059054096 @default.
• W4224993370 creator A5068290128 @default.
• W4224993370 creator A5070008051 @default.
• W4224993370 creator A5076712472 @default.
• W4224993370 date "2022-05-07" @default.
• W4224993370 modified "2023-10-15" @default.
• W4224993370 title "Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species <i>via</i> hypoxia inducible factor 1α" @default.
• W4224993370 cites W1979657807 @default.
• W4224993370 cites W2011376105 @default.
• W4224993370 cites W2015022497 @default.
• W4224993370 cites W2024563829 @default.
• W4224993370 cites W2038424551 @default.
• W4224993370 cites W2047642636 @default.
• W4224993370 cites W2079221401 @default.
• W4224993370 cites W2079481037 @default.
• W4224993370 cites W2094422430 @default.
• W4224993370 cites W2108573150 @default.
• W4224993370 cites W2113686534 @default.
• W4224993370 cites W2137827246 @default.
• W4224993370 cites W2146837510 @default.
• W4224993370 cites W2180909681 @default.
• W4224993370 cites W2209056371 @default.
• W4224993370 cites W2272431413 @default.
• W4224993370 cites W2557833949 @default.
• W4224993370 cites W2569874320 @default.
• W4224993370 cites W2735726751 @default.
• W4224993370 cites W2741636306 @default.
• W4224993370 cites W2769622412 @default.
• W4224993370 cites W2792646682 @default.
• W4224993370 cites W2798023735 @default.
• W4224993370 cites W2800240734 @default.
• W4224993370 cites W2891099970 @default.
• W4224993370 cites W2911001014 @default.
• W4224993370 cites W2911033210 @default.
• W4224993370 cites W2911288043 @default.
• W4224993370 cites W2914012279 @default.
• W4224993370 cites W2922572041 @default.
• W4224993370 cites W2925005839 @default.
• W4224993370 cites W2940346153 @default.
• W4224993370 cites W2941382852 @default.
• W4224993370 cites W2949018664 @default.
• W4224993370 cites W2956043140 @default.
• W4224993370 cites W2964111184 @default.
• W4224993370 cites W2972910483 @default.
• W4224993370 cites W2981153223 @default.
• W4224993370 cites W2983014891 @default.
• W4224993370 cites W2983196694 @default.
• W4224993370 cites W2995245446 @default.
• W4224993370 cites W2995420453 @default.
• W4224993370 cites W2995745149 @default.
• W4224993370 cites W2997177665 @default.
• W4224993370 cites W2998625568 @default.
• W4224993370 cites W3046334789 @default.
• W4224993370 cites W3047396053 @default.
• W4224993370 doi "https://doi.org/10.3748/wjg.v28.i17.1798" @default.
• W4224993370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35633910" @default.
• W4224993370 hasPublicationYear "2022" @default.
• W4224993370 type Work @default.
• W4224993370 citedByCount "1" @default.
• W4224993370 countsByYear W42249933702022 @default.
• W4224993370 crossrefType "journal-article" @default.
• W4224993370 hasAuthorship W4224993370A5032088677 @default.
• W4224993370 hasAuthorship W4224993370A5059054096 @default.
• W4224993370 hasAuthorship W4224993370A5068290128 @default.
• W4224993370 hasAuthorship W4224993370A5070008051 @default.
• W4224993370 hasAuthorship W4224993370A5076712472 @default.
• W4224993370 hasBestOaLocation W42249933701 @default.
• W4224993370 hasConcept C104317684 @default.
• W4224993370 hasConcept C127561419 @default.
• W4224993370 hasConcept C153911025 @default.
• W4224993370 hasConcept C160450060 @default.
• W4224993370 hasConcept C170493617 @default.
• W4224993370 hasConcept C181199279 @default.
• W4224993370 hasConcept C185592680 @default.
• W4224993370 hasConcept C203014093 @default.
• W4224993370 hasConcept C2776151105 @default.
• W4224993370 hasConcept C2776536020 @default.
• W4224993370 hasConcept C2776816829 @default.
• W4224993370 hasConcept C2778754761 @default.
• W4224993370 hasConcept C2780561631 @default.
• W4224993370 hasConcept C48349386 @default.
• W4224993370 hasConcept C55493867 @default.
• W4224993370 hasConcept C62478195 @default.
• W4224993370 hasConcept C75520062 @default.
• W4224993370 hasConcept C85265743 @default.
• W4224993370 hasConcept C86803240 @default.
• W4224993370 hasConcept C88045685 @default.
• W4224993370 hasConceptScore W4224993370C104317684 @default.
• W4224993370 hasConceptScore W4224993370C127561419 @default.
• W4224993370 hasConceptScore W4224993370C153911025 @default.
• W4224993370 hasConceptScore W4224993370C160450060 @default.
• W4224993370 hasConceptScore W4224993370C170493617 @default.
• W4224993370 hasConceptScore W4224993370C181199279 @default.
• W4224993370 hasConceptScore W4224993370C185592680 @default.
• W4224993370 hasConceptScore W4224993370C203014093 @default.

• next