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• W4224994472 abstract "Calcium-dependent protein kinases (CDPKs) are important in calcium influx, triggering several biological processes in Cryptosporidium spp. As they are not present in mammals, CDPKs are considered promising drug targets. Recent studies have characterized Cp CDPK1, Cp CDPK3, Cp CDPK4, Cp CDPK5, Cp CDPK6, and Cp CDPK9, but the role of Cp CPK2A remains unclear. In this work, we expressed recombinant Cp CDPK2A encoded by the cgd2_1060 gene in Escherichia coli and characterized the biologic functions of Cp CDPK2A using qRT-PCR, immunofluorescence microscopy, immuno-electron microscopy, and in vitro neutralization. The results revealed that Cp CDPK2A protein was highly expressed in the apical region of sporozoites and merozoites and in macrogamonts. Monoclonal or polyclonal antibodies against Cp CDPK2A failed to block the invasion of host cells. Among the 44 candidate inhibitors from molecular docking of Cp CDPK2A, one inhibitor was identified as having a potential effect on both Cryptosporidium parvum growth and Cp CDPK2A enzyme activities. These data suggest that Cp CDPK2A may play some roles during the development of C. parvum and might be a potential drug target against cryptosporidiosis." @default.
• W4224994472 created "2022-04-28" @default.
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• W4224994472 date "2022-04-25" @default.
• W4224994472 modified "2023-10-14" @default.
• W4224994472 title "Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis" @default.
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• W4224994472 doi "https://doi.org/10.3389/fmicb.2022.883674" @default.
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